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US4719313A
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Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
Assignee: Aventis Pharmaceuticals Inc
•
Filing: 1986-02-12
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Granted: 1988-01-12
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Expires: 2006-02-12
Abstract
Abstract Gem-dihalo and gem-tetrahalo-1,12-diamino-4,9-diaza-dodecane derivatives useful as antiproliferative or antitumor agents.
Inventors
- 👤 Fritz Gerhart
- 👤 Pierre Mamont
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 07:53
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
57 words
A gem-dihalo or tetrahalo-1,12-diamino-4,9-diaza-dodecane derivative having the formula ##STR6## wherein X and Y represent hydrogen or halogen, with the proviso that in the case of the dihalo derivatives both halogens are present on one and only one carbon atom, and in the case of the tetrahalo derivatives the compounds are 2,2,11,11-halo-substituted; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
57 words
A gem-dihalo or tetrahalo-1,12-diamino-4,9-diaza-dodecane derivative having the formula ##STR6## wherein X and Y represent hydrogen or halogen, with the proviso that in the case of the dihalo derivatives both halogens are present on one and only one carbon atom, and in the case of the tetrahalo derivatives the compounds are 2,2,11,11-halo-substituted; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
19 words
A compound according to claim 1 wherein the halogens are at the 6,6-position and the pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
19 words
A tetrahalo-1,12-diamino-4,9-diazo-dodecane derivative of the formula ##STR7## and the pharmaceutically acceptable salts thereof wherein X and Y are halogeno.
Claim 5
Dependent Claim
19 words
A tetrahalo-1,12-diamino-4,9-diazo-dodecane derivative of the formula ##STR7## and the pharmaceutically acceptable salts thereof wherein X and Y are halogeno.
Claim 6
Dependent Claim
6 words
6,6-Difluoro-1,12-diamino-4,9-diaza-dodecane and its pharmaceutically acceptable salts.
Claim 7
Dependent Claim
6 words
6,6-Difluoro-1,12-diamino-4,9-diaza-dodecane and its pharmaceutically acceptable salts.
Claim 8
Dependent Claim
6 words
2,2-difluoro-1,12-diamino-4,9-diazo-dodecane and its pharmaceutically acceptable salts.
Claim 9
Dependent Claim
6 words
2,2-difluoro-1,12-diamino-4,9-diazo-dodecane and its pharmaceutically acceptable salts.
References Cited (Backward Citations)
NL7514240A
Cited
US4004996A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-11 | 1991-07-13 | 1992-01-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-11 | 1995-07-13 | 1996-01-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-11 | 1999-07-13 | 2000-01-12 | $7700.00 | Window Closed / Lapsed |