Patent US4715387A successfully refreshed from Google Patents.
US4715387A
Expired / Lapsed
US
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Aerosol for use in the reduction of tobacco smoking
Assignee: University of California
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Filing: 1985-08-23
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Granted: 1987-12-29
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Expires: 2005-08-23
Abstract
Abstract A method and an apparatus and composition used in the reduction of the incidence of tobacco smoking and which comprises an aerosol for application to the oral cavity and respiratory tract of an individual. The aerosol contains a food acid, such as citric acid, which is present in non-toxic amounts and capable of being inhaled. The aerosol may be in the form of a liquid spray or a finely divided solid. The droplets or particles contained in the aerosol are of proper size and have the food acid sufficient in content to simulate the sensations in the upper respiratory tract caused by tobacco smoke. In this way, the oral cavity sensations and the respiratory tract sensations simulate those created by tobacco smoke to replace the need for tobacco smoke. In another embodiment of the invention the food acid aerosol contains tobacco smoke of proper particle size so that the food acid particles migrate to the respiratory tract and the tobacco smoke remains in the oral cavity. In still a further embodiment of the invention, the aerosol contains small particles of a carrier such as a saccharide with tobacco smoke adsorbed thereon. In still another embodiment, the aerosol can be used in combination with a transdermal application of nicotine.
Inventors
- 👤 Jed E. Rose
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:27
CPC Classifications
A; A61; A61M; A61M15/00; A61M11/00; A61M11/001; A61M15/009; A61M2202/00; A61M2202/06; A61M2202/064
Claims Analysis
Total Claims: 53
Claim 1
Independent Claim
139 words
A method of aiding in the reduction of incidence of tobacco smoking by simulating respiratory tract sensations approximating those obtained by inhalation of normal tobacco smoke, said method comprising administering an aerosol to the oral cavity of an individual and which aerosol contains particles of a food acid which is present in non-toxic amounts and capable of being inhaled, the particles being of a proper size and having the food acid sufficient in content to migrate to the respiratory tract and simulate the sensations in the respiratory tract caused by tobacco smoke, the size of the particles being established so that at least a moderately substantial portion of the particles remain in the upper respiratory tract, whereby the oral and respiratory tract sensations simulate those created by tobacco smoke to reduce the need of an individual for tobacco smoke.
Claim 2
Independent Claim
139 words
A method of aiding in the reduction of incidence of tobacco smoking by simulating respiratory tract sensations approximating those obtained by inhalation of normal tobacco smoke, said method comprising administering an aerosol to the oral cavity of an individual and which aerosol contains particles of a food acid which is present in non-toxic amounts and capable of being inhaled, the particles being of a proper size and having the food acid sufficient in content to migrate to the respiratory tract and simulate the sensations in the respiratory tract caused by tobacco smoke, the size of the particles being established so that at least a moderately substantial portion of the particles remain in the upper respiratory tract, whereby the oral and respiratory tract sensations simulate those created by tobacco smoke to reduce the need of an individual for tobacco smoke.
Claim 3
Dependent Claim
43 words
The method of claim 1 further characterized in that said method comprises administering the aerosol spray which contains the food acid in water and where the food acid is present in an amount of about 8% to about 35% by weight in water.
Claim 4
Dependent Claim
32 words
The method of claim 1 further characterized in that the food acid is selected from the class consisting of citric acid, ascorbic acid, adipic acid, tartaric acid, and mixtures of the foregoing.
Claim 5
Dependent Claim
31 words
The method of claim 1 further characterized in that said method comprises varying the size of the particles to correspond to the portion of the respiratory tract where simulation is desired.
Claim 6
Dependent Claim
26 words
The method of claim 1 further characterized in that said aerosol has particles of a size ranging between 1 micron to about 15 microns in diameter.
Claim 7
Dependent Claim
26 words
The method of claim 1 further characterized in that said aerosol has particles of a size ranging between 5 microns to about 10 microns in diameter.
Claim 8
Dependent Claim
89 words
An aerosol spray for inhalation to aid in smoking incidence reduction, said spray comprising a liquid carrier with a food acid disolved therein, the food acid being present in a non-toxic amount which is capable of being inhaled and also present in an amount sufficient to simulate the sensations in the respiratory tract caused by tobacco smoke, the droplets of said spray having a proper size to migrate from the oral cavity to the respiratory tract to cause such sensations therein and thereby replace the need for tobacco smoke.
Claim 9
Dependent Claim
89 words
An aerosol spray for inhalation to aid in smoking incidence reduction, said spray comprising a liquid carrier with a food acid disolved therein, the food acid being present in a non-toxic amount which is capable of being inhaled and also present in an amount sufficient to simulate the sensations in the respiratory tract caused by tobacco smoke, the droplets of said spray having a proper size to migrate from the oral cavity to the respiratory tract to cause such sensations therein and thereby replace the need for tobacco smoke.
Claim 10
Dependent Claim
15 words
The aerosol spray of claim 7 further characterized in that the liquid carrier is water.
Claim 11
Dependent Claim
30 words
The aerosol spray of claim 7 further characterized in that the food acid is present in the liquid carrier in an amount of about 8% to about 35% by weight.
Claim 12
Dependent Claim
33 words
The aerosol spray of claim 7 further characterized in that the food acid is selected from the class consisting of citric acid, ascorbic acid, adipic acid, tartaric acid, and mixtures of the foregoing.
Claim 13
Dependent Claim
16 words
The aerosol spray of claim 7 further characterized in that the food acid is citric acid.
Claim 14
Dependent Claim
37 words
The aerosol spray of claim 7 further characterized in that the food acid is citric acid and is present in the liquid carrier, which is water, in an amount of about 15% to about 25% by weight.
Claim 15
Dependent Claim
24 words
The aerosol spray of claim 8 further characterized in that the droplets have a size ranging from about 1 micron to about 15 microns.
Claim 16
Dependent Claim
24 words
The aerosol spray of claim 8 further characterized in that the droplets have a size ranging from about 5 microns to about 10 microns.
Claim 17
Dependent Claim
24 words
The aerosol spray of claim 8 further characterized in that the spray is contained in and dispensed from a nebulizer as a fine mist.
Claim 18
Dependent Claim
32 words
The aerosol spray of claim 7 further characterized in that an emulsifier is incorporated into a liquid carrier with the food acid dissolved therein to reduce surface tension and control particle size.
Claim 19
Dependent Claim
14 words
The aerosol spray of claim 16 further characterized in that the emulsifier is lecithin.
Claim 20
Independent Claim
79 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol to the oral cavity of an individual which contains a nebulized food acid capable of being inhaled and of a first particle size and particles of a second particle size containing tobacco smoke, so that the food acid particle size is selected to migrate to the respiratory tract and the tobacco smoke containing particles will generally remain in the oral cavity.
Claim 21
Independent Claim
79 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol to the oral cavity of an individual which contains a nebulized food acid capable of being inhaled and of a first particle size and particles of a second particle size containing tobacco smoke, so that the food acid particle size is selected to migrate to the respiratory tract and the tobacco smoke containing particles will generally remain in the oral cavity.
Claim 22
Dependent Claim
24 words
The method of claim 18 further characterized in that the food acid particles are of a smaller size than the tobacco smoke containing particles.
Claim 23
Dependent Claim
32 words
The method of claim 18 further characterized in that the food acid is selected from the class consisting of citric acid, ascorbic acid, adipic acid, tartaric acid, and mixtures of the foregoing.
Claim 24
Dependent Claim
15 words
The method of claim 18 further characterized in that the food acid is citric acid.
Claim 25
Dependent Claim
55 words
The method of claim 19 further characterized in that said method comprises administering an aerosol spray which contains a mixture of the food acid and tobacco smoke in a relatively inert liquid carrier and where the food acid is present in an amount of about 9% to about 35% by weight in the liquid carrier.
Claim 26
Dependent Claim
57 words
The method of claim 19 further characterized in that said method comprises administering an aerosol spray which contains a mixture of the food acid in water and tobacco smoke in a liquid carrier which is water and where the food acid is present in an amount of about 9% to about 35% by weight in the water.
Claim 27
Dependent Claim
52 words
The method of claim 23 further charcterized in that said method comprises administering an aerosol spray which contains a mixture of the food acid and tobacco smoke in water and where the food acid is citric acid present in an amount of about 15% to about 25% by weight in the water.
Claim 28
Dependent Claim
55 words
The method of claim 19 further characterized in that said method comprises administering an aerosol which contains a mixture of the food acid in a solid particulate form and particles containing tobacco smoke in solid particulate form and which mixture is sufficiently fluidized so as to be nebulized similar to that of a liquid spray.
Claim 29
Dependent Claim
15 words
The method of claim 23 further characterized in that the mixture comprises an emulsifier therein.
Claim 30
Dependent Claim
68 words
An aerosol for inhalation to aid in smoking incidence reduction, said aerosol containing particles of a food acid present in non-toxic amounts and having a first particle size and particles with tobacco smoke thereon in combination therewith and having a second particle size so that the food acid particles migrate to the respiratory tract and where the tobacco smoke containing particles will generally remain in the oral cavity.
Claim 31
Dependent Claim
68 words
An aerosol for inhalation to aid in smoking incidence reduction, said aerosol containing particles of a food acid present in non-toxic amounts and having a first particle size and particles with tobacco smoke thereon in combination therewith and having a second particle size so that the food acid particles migrate to the respiratory tract and where the tobacco smoke containing particles will generally remain in the oral cavity.
Claim 32
Dependent Claim
18 words
The aerosol of claim 27 further characterized in the particles are in a mixture in a liquid carrier.
Claim 33
Dependent Claim
14 words
The aerosol of claim 28 further characterized in that the liquid carrier is water.
Claim 34
Dependent Claim
27 words
The aerosol of claim 25 further characterized in that the tobacco particles comprise a saccharide base and the tobacco particles and food acid are a solid mixture.
Claim 35
Dependent Claim
27 words
The aerosol of claim 25 further characterized in that the tobacco particles comprise a starch base and the tobacco particles and food acid are a solid mixture.
Claim 36
Dependent Claim
15 words
The aerosol of claim 27 further characterized in that the food acid is citric acid.
Claim 37
Dependent Claim
25 words
The aerosol of claim 27 further characterized in that the food acid particles have a size ranging from about 1 micron to about 12 microns.
Claim 38
Dependent Claim
25 words
The aerosol of claim 27 further characterized in that the food acid particles have a size ranging from about 5 microns to about 10 microns.
Claim 39
Independent Claim
61 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol which contains a nebulized food acid capable of being inhaled to the oral cavity of an individual, and transdermally applying nicotine to an individual having the aerosol administered thereto so that the nicotine can satisfy a nicotine demand in the blood stream thereof.
Claim 40
Independent Claim
61 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol which contains a nebulized food acid capable of being inhaled to the oral cavity of an individual, and transdermally applying nicotine to an individual having the aerosol administered thereto so that the nicotine can satisfy a nicotine demand in the blood stream thereof.
Claim 41
Dependent Claim
32 words
The method of claim 35 further characterized in that the aerosol has a particle size sufficient so that the particles of the aerosol will migrate to the respiratory tract of the user.
Claim 42
Dependent Claim
32 words
The method of claim 35 further characterized in that the food acid is selected from the class consisting of citric acid, ascorbic acid, adipic acid, tartic acid and mixtures of the foregoing.
Claim 43
Dependent Claim
15 words
The method of claim 37 further characterized in that the food acid is citric acid.
Claim 44
Dependent Claim
28 words
The method of claim 35 further characterized in that the nicotine is transdermally applied to the individual by a transdermal patch located on the skin of the user.
Claim 45
Independent Claim
63 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising generating an aerosol which contains saccharide particles, with tobacco smoke adsorbed on the surface thereof, administering the aerosol thus generated to the oral cavity of an individual and with the particles having a particle size so that the tobacco smoke adsorbed saccharide will migrate to the respiratory tract.
Claim 46
Independent Claim
63 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising generating an aerosol which contains saccharide particles, with tobacco smoke adsorbed on the surface thereof, administering the aerosol thus generated to the oral cavity of an individual and with the particles having a particle size so that the tobacco smoke adsorbed saccharide will migrate to the respiratory tract.
Claim 47
Dependent Claim
14 words
The method of claim 40 further characterized in that the particles are a starch.
Claim 48
Independent Claim
140 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol in a spray form to the oral cavity of an individual and which aerosol contains particles of a food acid incorporated in a relatively inert liquid carrier, said food acid being present in an amount of about 8% to about 35% by weight in the liquid carrier and in which said food acid is present in said aerosol in non-toxic amounts and capable of being inhaled, the particles being of a proper size and having the food acid sufficient in content to migrate to the respiratory tract and simulate the sensations in the respiratory tract caused by tobacco smoke, whereby the oral and respiratory tract sensations simulate those created by tobacco smoke to reduce the need of tobacco smoking by an individual.
Claim 49
Independent Claim
140 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol in a spray form to the oral cavity of an individual and which aerosol contains particles of a food acid incorporated in a relatively inert liquid carrier, said food acid being present in an amount of about 8% to about 35% by weight in the liquid carrier and in which said food acid is present in said aerosol in non-toxic amounts and capable of being inhaled, the particles being of a proper size and having the food acid sufficient in content to migrate to the respiratory tract and simulate the sensations in the respiratory tract caused by tobacco smoke, whereby the oral and respiratory tract sensations simulate those created by tobacco smoke to reduce the need of tobacco smoking by an individual.
Claim 50
Dependent Claim
14 words
The method of claim 42 further characterized in that the liquid carrier is water.
Claim 51
Dependent Claim
15 words
The method of claim 42 further characterized in that the food acid is citric acid.
Claim 52
Independent Claim
122 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol spray to the oral cavity of an individual and which aerosol contains particles of a citric acid contained in water and in non-toxic amounts and capable of being inhaled, the citric acid being present in an amount of about 15% to about 25% by weight in the water, the particles being of a proper size and having the food acid sufficient in content to migrate to the respiratory tract and simulate the sensations in the respiratory tract caused by tobacco smoke, whereby the oral and respiratory tract sensations simulate those created by tobacco smoke to reduce the need of tobacco smoking by an individual.
Claim 53
Independent Claim
122 words
A method of aiding in the reduction of incidence of tobacco smoking, said method comprising administering an aerosol spray to the oral cavity of an individual and which aerosol contains particles of a citric acid contained in water and in non-toxic amounts and capable of being inhaled, the citric acid being present in an amount of about 15% to about 25% by weight in the water, the particles being of a proper size and having the food acid sufficient in content to migrate to the respiratory tract and simulate the sensations in the respiratory tract caused by tobacco smoke, whereby the oral and respiratory tract sensations simulate those created by tobacco smoke to reduce the need of tobacco smoking by an individual.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-28 | 1991-06-29 | 1991-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-28 | 1995-06-29 | 1995-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-28 | 1999-06-29 | 1999-12-29 | $7700.00 | Window Closed / Lapsed |