US4713245A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Granule containing physiologically-active substance, method for preparing same and use thereof
Assignee: Mitsui Toatsu Chemicals Inc
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Filing: 1985-05-24
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Granted: 1987-12-15
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Expires: 2005-05-24
Abstract
Abstract Disclosed herein is a granule containing physiologically-active substance which comprises at least (A): a physiologically-active substance; (B): a substance which is stable under neutral condition but disintegrates or dissolves at a pH of 3 or less; and (C): at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having at least 14 carbon atoms and salts thereof, animal fats having a melting point of 40 DEG C. or higher, vegetable fats having a melting point of 40 DEG C. or higher and waxes having a melting point of 40 DEG C. or higher, and which granule further has a protective film comprising at least said substances (B) and (C) on the surface thereof. The protective film has a thickness of preferably at most 20% of the granular diameter and is preferably at least composed of at least 10% by weight of the substance (B) and at most 90% by weight of the substance (C). Granules having this specific protective film on the surface thereof have the use as a feed additive composition. A method for preparing said granules is also disclosed.
Inventors
- 👤 Shinji Ando
- 👤 Masami Ohtaguro
- 👤 Takayoshi Masuda
- 👤 Yoshimoto Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 04:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/48; A61K9/50; A61K9/5005; A61K9/501; A23; A23K; A23K40/00; A23K40/30; A23K40/35; A61K9/1605; A61K9/1611; A61K9/1617; A61K9/1629; A61K9/1635; A61K9/1652; Y; Y10; Y10S; Y10S426/00; Y10S426/807
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
206 words
In a method for preparing a granule containing physiologically-active substance which contains at least: (A) a physiologically-active substance; (B) a substance which is stable under neutral conditions but disintegrates or dissolves at a pH of 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 90 percent by weight based on the total amount of the granule; and (C) at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher, the improvement which comprises subjecting said granule to a heat treatment to treat only the surface thereof at temperature higher than the melting point of said substance (C), thereby forming a protective film containing at least said substance (B) and (C) on the surface thereof.
Claim 2
Dependent Claim
206 words
In a method for preparing a granule containing physiologically-active substance which contains at least: (A) a physiologically-active substance; (B) a substance which is stable under neutral conditions but disintegrates or dissolves at a pH of 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 90 percent by weight based on the total amount of the granule; and (C) at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher, the improvement which comprises subjecting said granule to a heat treatment to treat only the surface thereof at temperature higher than the melting point of said substance (C), thereby forming a protective film containing at least said substance (B) and (C) on the surface thereof.
Claim 3
Dependent Claim
217 words
In a method for preparing a granule containing physiologically-active substance which contains at least: (A) a physiologically-active substance; (B) a substance which is stable under neutral conditions but disintegrates or dissolves at a pH of 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 90 percent by weight based on the weight of the granule containing at least the substances (A) and (C); and (C): at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher, the improvement which comprises subjecting a granule which has been previously prepared and contains at least said substances (A) and (C) to a heat treatment to treat the surface thereof at a temperature higher than the melting point of said substance (C) in the presence of said substance (B).
Claim 4
Dependent Claim
217 words
In a method for preparing a granule containing physiologically-active substance which contains at least: (A) a physiologically-active substance; (B) a substance which is stable under neutral conditions but disintegrates or dissolves at a pH of 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 90 percent by weight based on the weight of the granule containing at least the substances (A) and (C); and (C): at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher, the improvement which comprises subjecting a granule which has been previously prepared and contains at least said substances (A) and (C) to a heat treatment to treat the surface thereof at a temperature higher than the melting point of said substance (C) in the presence of said substance (B).
Claim 5
Dependent Claim
223 words
Method for preparing a feed additive composition capable of passing through the rumen substantially unaltered and of dissolving in the abomasum of ruminants which comprises granulating a mixture containing at least: (A) a physiologically-active substance; (B) a substance which is stable under neutral conditions but disintegrates or dissolves at a pH 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 90 percent by weight based on the amount of the granule; and (C) at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher and then subjecting the resultant granule to a heat treatment to treat only the surface thereof at a temperature higher than the melting point of said substance (C) long enough to form a protective film containing at least said substances (B) and (C) on the surface thereof.
Claim 6
Dependent Claim
223 words
Method for preparing a feed additive composition capable of passing through the rumen substantially unaltered and of dissolving in the abomasum of ruminants which comprises granulating a mixture containing at least: (A) a physiologically-active substance; (B) a substance which is stable under neutral conditions but disintegrates or dissolves at a pH 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 90 percent by weight based on the amount of the granule; and (C) at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher and then subjecting the resultant granule to a heat treatment to treat only the surface thereof at a temperature higher than the melting point of said substance (C) long enough to form a protective film containing at least said substances (B) and (C) on the surface thereof.
Claim 7
Dependent Claim
223 words
Method for preparing a feed additive composition capable of passing through the rumen substantially unaltered and of dissolving in the abomasum of ruminants which comprises granulating a mixture containing at least: (A) physiologically-active substance; (C) at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher; and subjecting the resultant granule to a heat treatment to treat only the surface thereof at a temperature higher than the melting point of said substance (C) in the presence of a substance (B) which is stable under neutral conditions but disintegrates or dissolves at a pH 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 80 percent by weight based on the weight of the granule containing at least the substances (A) and (B), thereby forming a film on the surface of the granule.
Claim 8
Dependent Claim
223 words
Method for preparing a feed additive composition capable of passing through the rumen substantially unaltered and of dissolving in the abomasum of ruminants which comprises granulating a mixture containing at least: (A) physiologically-active substance; (C) at least one substance selected from the group consisting of straight-chain or branched, saturated or unsaturated monocarboxylic acids having 14 carbon atoms or more and salts thereof, animal fats having a melting point of 40° C. or higher, vegetable fats having a melting point of 40° C. or higher and waxes having a melting point of 40° C. or higher; and subjecting the resultant granule to a heat treatment to treat only the surface thereof at a temperature higher than the melting point of said substance (C) in the presence of a substance (B) which is stable under neutral conditions but disintegrates or dissolves at a pH 3 or less, said substance being selected from the group consisting of cellulose derivatives, polyvinyl derivatives, nitrogen-containing polysaccharides, metal salts of a polysaccharide and water-insoluble salts of an acid which is less acidic than hydrochloric acid and is acceptable to a living body, the amount of said substance ranging from 5 to 80 percent by weight based on the weight of the granule containing at least the substances (A) and (B), thereby forming a film on the surface of the granule.
Claim 9
Dependent Claim
25 words
The method as claimed in claim 3 wherein the temperature ranges from 80° to 120° C. and the time ranges from 10 to 60 minutes.
Claim 10
Dependent Claim
25 words
The method as claimed in claim 4 wherein the temperature ranges from 90° to 120° C. and the time ranges from 5 to 120 minutes.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-14 | 1991-06-15 | 1991-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-14 | 1995-06-15 | 1995-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-14 | 1999-06-15 | 1999-12-15 | $7700.00 | Window Closed / Lapsed |