US4711906A
Expired / Lapsed
US
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Liquid diclofenac preparations
Assignee: Merckle GmbH
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Filing: 1985-12-20
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Granted: 1987-12-08
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Expires: 2005-12-20
Abstract
Abstract Disclosed are aqueous, stable, relatively concentrated solutions of diclofenac, which contain a mixture of propylene glycol and polyethylene glycol in defined quantitative proportions. The solutions preferably contain a local anesthetic such as lidocaine and a reducing agent as stabilizer.
Inventors
- 👤 Otto von Stetten
- 👤 Pyare L. Seth
- 👤 Franz Schmid
- 👤 Kurt Rauchle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:54
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K47/00; A61K47/06; A61K47/08; A61K47/10
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
73 words
A stable, liquid diclofenac preparation, especially for the parenteral application, consisting of a solution of diclofenac or one of its salts in an amount of 1.5-6.0 weight % diclofenac in a solvent, wherein the solvent consists of 10-70 weight % of a mixture of (a) propylene glycol and (b) polyethylene glycol and 30-90 weight % water, and the weight ratio of (a) propylene glycol to (b) polyethyelene glycol is between 9.5:0.5 and 0.5:9.5.
Claim 2
Dependent Claim
73 words
A stable, liquid diclofenac preparation, especially for the parenteral application, consisting of a solution of diclofenac or one of its salts in an amount of 1.5-6.0 weight % diclofenac in a solvent, wherein the solvent consists of 10-70 weight % of a mixture of (a) propylene glycol and (b) polyethylene glycol and 30-90 weight % water, and the weight ratio of (a) propylene glycol to (b) polyethyelene glycol is between 9.5:0.5 and 0.5:9.5.
Claim 3
Dependent Claim
24 words
The diclofenac preparation according to claim 1, wherein the weight ratio of (a) propylene glycol to (b) polyethylene glycol is between 2:1 and 1:2.
Claim 4
Dependent Claim
13 words
The dicyclofenac preparation according to claim 1 having a pH value of 5.5-9.
Claim 5
Dependent Claim
17 words
The diclofenac preparation according to claim 1 containing a polyethylene glycol 400 as the polyethylene glycol component.
Claim 6
Dependent Claim
18 words
The diclofenac prparations according to claim 1 which further consists of 0.1-5 weight % of a local anesthetic.
Claim 7
Dependent Claim
13 words
The diclofenac preparation according to claim 5, wherein the local anesthetic is lidocaine.
Claim 8
Dependent Claim
13 words
The diclofenac preparation according to claim 6 having a pH value of 7.5-8.
Claim 9
Dependent Claim
22 words
The diclofenac preparation according to claim 1 which further consists of 0.05 to 5 weight % of a reducing agent as stabilizer.
Claim 10
Dependent Claim
27 words
The diclofenac preparation according to claim 8, wherein the reducing agent is selected from the group consisting of sodium-disulfite, cysteine-hydrochloride, N-acetyl cysteine hydrochloride, sodium-thiosulfate and mixtures thereof.
Claim 11
Dependent Claim
15 words
The diclofenac preparation according to claim 1 which further consists of an anti-inflammatorily active drug.
Claim 12
Dependent Claim
54 words
The diclofenac preparation according to claim 9, wherein said preparation consists essentially of 3 to 4 weight % diclofenac sodium, about 24 weight % propylene glycol, about 18 weight % polyethylene glycol 400, about 1 weight % lidocaine-hydrochloride, about 0.1 weight % sodium-disulfite, and the remainer being water, having a pH value of 8.
Claim 13
Dependent Claim
32 words
The diclofenac preparation according to claim 1 wherein said solvent consists of 20-50 weight % of a mixture of (a) propylene glycol and (b) polyethylene glycol and 50-80 weight % of water.
Claim 14
Dependent Claim
23 words
The diclofenac preparation according to claim 1 wherein the weight ratio of (a) glycol to (b) polyethylene glycol is between 3:1 and 1:3.
Claim 15
Dependent Claim
12 words
The diclogenac preparation according to claim 3 having a pH of 6.0-8.5.
Claim 16
Dependent Claim
12 words
The diclofenac preparation according to claim 3 having a pH of 6.5-8.0.
Claim 17
Dependent Claim
16 words
The diclofenac preparation of claim 5 wherein 0.5-2 weight % of a local anesthetic is present.
Claim 18
Dependent Claim
52 words
A liquid diclofenac preparation, especially for the parental application, consisting of a solution of diclofenac or one of its salts in a solvent, wherein the solvent consists of 20-50 weight % of a mixture of propylene glycol and polyethylene glycol in a weight ratio of 3:1-1:3 and 50-80 weight % of water.
Claim 19
Dependent Claim
52 words
A liquid diclofenac preparation, especially for the parental application, consisting of a solution of diclofenac or one of its salts in a solvent, wherein the solvent consists of 20-50 weight % of a mixture of propylene glycol and polyethylene glycol in a weight ratio of 3:1-1:3 and 50-80 weight % of water.
Claim 20
Dependent Claim
75 words
A stable, liquid diclofenac preparation, especially for the parenteral application, consisting of a solution of diclofenac or one of its salts in an amount of 1.5-6.0 weight % diclofenac, 0.5-2 weight % of a local anesthetic, 0.05-5 weight % of a reducing agent in a solvent, wherein the solvent consists of 20-50 weight % of a mixture or propylene glycol and polyethylene glycol in a weight ratio of 3:1-1:3 and 50-80 weight % of water.
Claim 21
Dependent Claim
75 words
A stable, liquid diclofenac preparation, especially for the parenteral application, consisting of a solution of diclofenac or one of its salts in an amount of 1.5-6.0 weight % diclofenac, 0.5-2 weight % of a local anesthetic, 0.05-5 weight % of a reducing agent in a solvent, wherein the solvent consists of 20-50 weight % of a mixture or propylene glycol and polyethylene glycol in a weight ratio of 3:1-1:3 and 50-80 weight % of water.
Claim 22
Dependent Claim
19 words
The diclofenac preparation of claim 18 wherein the local anesthetic is lidocaine and the reducing agent is sodium disulfite.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-07 | 1991-06-08 | 1991-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-07 | 1995-06-08 | 1995-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-07 | 1999-06-08 | 1999-12-08 | $7700.00 | Window Closed / Lapsed |