Quinolone inotropic agents

Abstract

Abstract A heterocyclic-substituted 2-quinolone compound of the formula: <IMAGE> (I) or a pharmaceutically-acceptable salt thereof, wherein "Het" is an optionally substituted 5-or 6-membered monocyclid aromatic heterocyclic group attached by a carbon atom to the 5-, 6-, 7- or 8- position of the quinolone nucleus; R, which is attached to the 5-, 6-, 7- or 8- position, is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphinyl, C1-C4 alkylsulphonyl, halo, CF3, hydroxy, hydroxymethyl, or cyano; R1 is hydrogen, cyano (C1-C4 alkoxy)carbonyl, C1-C4 alkyl, nitro, halo, -NR3R4 or -CONR3R4 where each of R3 and R4 is hydrogen or C1-C4 alkyl or R3 and R4 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic group optionally containing a further heteroatom or group selected from O, S and N-R5 where R5 is hydrogen or C 1-C4 alkyl; R2 is hydrogen, C1-C4 alkyl, or 2-hydroxyethyl; Y is hydrogen or C1-C4 alkyl; and the dotted line between the 3- and 4- positions represents an optional bond. The compounds are inotropic agents useful as cardiac stimulants in the treatment of congestive heart failure.

Inventors

• 👤 Simon F. Campbell
• 👤 David A. Roberts

Bibliographic Details