Patent US4710384A successfully refreshed from Google Patents.
US4710384A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release tablets made from microcapsules
Assignee: Bio Dar Ltd
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Filing: 1986-07-28
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Granted: 1987-12-01
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Expires: 2006-07-28
Abstract
Abstract A tablet for oral adminstration of a sustained-release medication is formed by compressing microcapsules of the active principle. The microcapsules are of a size range between about 5 and 300 microns and comprise particles of active principle coated with a thin, flexible layer of sustained release material. The sustained-release material contains about 15-30% by weight thereof of plasticizer and is coated in an amount corresponding to 10-25% of the weight of the active material. Excipients causing disintegration of the tablet after administration can be uniformly mixed with the microcapsules prior to compression.
Inventors
- 👤 Avner Rotman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/0002; A61K9/0007
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
116 words
A new sustained release galenical form in the form of a disintegratable tablet, comprising compressed microcapsules of active principle and a pharmaceutically acceptable excipient interspersed among and throughly mixed with said microcapsules, wherein said microcapsules have a size range distributed between about 5 and about 300 microns and comprise particles of active principle coated with an encapsulating layer of an ethyl cellulose or acrylic resin sustained release polymer containing a sufficient amount of plasticizer to render said coating flexible, said amount being within the range of about 15 to about 30% of the weight of said sustained release polymer, said coating being no thicker than that which forms 25% of the weight of the active principle.
Claim 2
Dependent Claim
116 words
A new sustained release galenical form in the form of a disintegratable tablet, comprising compressed microcapsules of active principle and a pharmaceutically acceptable excipient interspersed among and throughly mixed with said microcapsules, wherein said microcapsules have a size range distributed between about 5 and about 300 microns and comprise particles of active principle coated with an encapsulating layer of an ethyl cellulose or acrylic resin sustained release polymer containing a sufficient amount of plasticizer to render said coating flexible, said amount being within the range of about 15 to about 30% of the weight of said sustained release polymer, said coating being no thicker than that which forms 25% of the weight of the active principle.
Claim 3
Dependent Claim
22 words
A galenical form in accordance with claim 1, wherein said excipient includes a material for causing disintegration of the tablet after administration.
Claim 4
Dependent Claim
27 words
A galenical form in accordance with claim 1, wherein said plasticizer is present in an amount of about 15-20% of the weight of said sustained release polymer.
Claim 5
Dependent Claim
23 words
A galenical form in accordance with claim 1, wherein said microcapsules have a size range distributed between about 30 and about 250 microns.
Claim 6
Dependent Claim
32 words
A galenical form in accordance with claim 1, wherein said sustained release polymer is coated on said active principle in an amount corresponding to 10-25% of the weight of the active material.
Claim 7
Dependent Claim
29 words
A galenical form in accordance with claim 5, wherein said sustained release polymer is coated on said active principle in an amount corresponding to 15-20% of said active material.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-30 | 1991-06-01 | 1991-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-30 | 1995-06-01 | 1995-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-30 | 1999-06-01 | 1999-12-01 | $7700.00 | Window Closed / Lapsed |