US4707439A
Expired / Lapsed
US
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Screening test for reverse-transcriptase containing virus such as non-A, non-B hepatitis, NANBH
Assignee: United States, AS REPRESENTED BY SECREARY OF DEPARTMENT OF HEALTH AND HUMAN SERVICES
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Filing: 1984-10-26
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Granted: 1987-11-17
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Expires: 2004-10-26
Abstract
Abstract The present invention discloses a screening test for detecting the presence of contaminating or infectious agents causing non-A, non-B hepatitis or AIDS in a blood donor setting. A kit for the detection of contaminating agents belonging to the group of retroviruses is also disclosed. Screening blood or blood related products so as to prevent spreading of infection or contamination due to retroviruses is now made possible by the present invention.
Inventors
- 👤 Belinda P. Seto
- 👤 William G. Coleman, Jr.
- 👤 Robert J. Gerety
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 15:41
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/48; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56983; G01N33/56988; G01N33/573; G01N33/576; G01N33/5767; Y; Y10; Y10S; Y10S436/00; Y10S436/82
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
104 words
A method for screening a blood composition for the presence of retrovirus particles associated with non-A, non-B hepatitis comprising: (a) isolating said retrovirus particles from a sample of blood composition; (b) disrupting or lysing the isolated retrovirus particles to thereby release the reverse transcriptase therefrom; (c) assaying the reverse transcriptase activity; (d) comparing the activity assayed in step (c) with that assayed in a similarly treated control sample; and (e) concluding the presence of retrovirus particles associated with non-A, non-B hepatitis in said blood composition when the reverse transcriptase activity in the blood composition is about twice or more than that in the control.
Claim 2
Independent Claim
104 words
A method for screening a blood composition for the presence of retrovirus particles associated with non-A, non-B hepatitis comprising: (a) isolating said retrovirus particles from a sample of blood composition; (b) disrupting or lysing the isolated retrovirus particles to thereby release the reverse transcriptase therefrom; (c) assaying the reverse transcriptase activity; (d) comparing the activity assayed in step (c) with that assayed in a similarly treated control sample; and (e) concluding the presence of retrovirus particles associated with non-A, non-B hepatitis in said blood composition when the reverse transcriptase activity in the blood composition is about twice or more than that in the control.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein the blood composition to be screened is serum, plasma or a fraction or product derived from plasma or serum.
Claim 4
Dependent Claim
17 words
The method of claim 1 wherein the assaying of step (c) is carried out histologically or immunochemically.
Claim 5
Dependent Claim
49 words
A method of preventing transmission between living subjects of a non-A, non-B hepatitis infection comprising identifying a blood composition from one subject as having retrovirus particles associated with non-A, non-B hepatitis by the method of claim 1 and isolating the blood composition or individual so infected from living subjects.
Claim 6
Independent Claim
94 words
A method for screening a blood composition for the presence of retrovirus particles comprising: (a) isolating said retrovirus particles from a sample of blood composition; (b) disrupting or lysing the isolated retrovirus particles to thereby release the reverse transcriptase therefrom; (c) assaying the reverse transcriptase activity; (d) comparing the activity assayed in step (c) with that assayed in a similarly treated control sample; and (e) concluding the presence of retrovirus particles in said blood composition when the reverse transcriptase activity in the blood composition is about twice or more than that in the control.
Claim 7
Independent Claim
94 words
A method for screening a blood composition for the presence of retrovirus particles comprising: (a) isolating said retrovirus particles from a sample of blood composition; (b) disrupting or lysing the isolated retrovirus particles to thereby release the reverse transcriptase therefrom; (c) assaying the reverse transcriptase activity; (d) comparing the activity assayed in step (c) with that assayed in a similarly treated control sample; and (e) concluding the presence of retrovirus particles in said blood composition when the reverse transcriptase activity in the blood composition is about twice or more than that in the control.
Claim 8
Dependent Claim
25 words
The method of claim 5 wherein the blood composition to be screened is serum, plasma or a fraction or product derived from plasma or serum.
Claim 9
Dependent Claim
17 words
The method of claim 5 wherein the assaying of step (c) is carried out histologically or immunochemically.
Claim 10
Dependent Claim
42 words
A method of preventing transmission between living subjects of a retrovirus infection comprising identifying a blood composition from one subject as having retrovirus particles by the method of claim 5 and isolating the blood composition or individual so infected from living subjects.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-11-16 | 1991-05-18 | 1991-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-16 | 1995-05-18 | 1995-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-16 | 1999-05-18 | 1999-11-17 | $7700.00 | Window Closed / Lapsed |