US4696745A
Expired / Lapsed
US
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Separating agent with fluoroalkyl group
Assignee: Mitsubishi Chemical Corp
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Filing: 1986-04-09
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Granted: 1987-09-29
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Expires: 2006-04-09
Abstract
Abstract A method for producing a separating agent having a fluorine-containing group and a hydrophilic group, wherein a cross-linking component consisting of alkylene di(meth)acrylate and/or glycerine poly(meth)acrylate, and a principal chain component consisting of ester and/or ether having therein a polymerizable vinyl group or isopropenyl group and a functional group are subjected to suspension-polymerization to obtain a cross-linked copolymer, and then the functional group in the copolymer is subjected to chemical modification with a fluorine-containing compound or with both fluorine-containing compound and hydrophilic-group-containing compound. The separating agent of the present invention consists essentially of porous cross-linked copolymer particles having porosity in a range of from 0.5 to 3 ml/g and an average particle size in a range of from 1 to 2,000 mu m.
Inventors
- 👤 Takaharu Itagaki
- 👤 Hiroshi Kusano
- 👤 Eiji Miyata
- 👤 Hirohisa Kubota
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:37
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/18; B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/265; B01J20/267; B01J20/281; B01J20/286
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
216 words
A separating agent, consisting essentially of porous particles of a cross-linked copolymer having a porosity in a range of from 0.5 to 3 ml/g and an average particle diameter in a range of from 1 to 2,000 μm, said copolymer being composed essentially of a cross-linking component consisting of alkylene di(meth)acrylate and/or glycerine poly(meth)acrylate; an ester component containing a fluorine compound represented by the following general formulae (1) and/or (2); and a glycerine-derived ester component and/or a polyethylene glycol ester component represented by the following general formulae (3) and/or (4): ##STR10## (in the above general formulae (1) and (2), R 1 denotes hydrogen or a methyl group; X represents a methylene group or a carbonyl group; and Rf designates a fluoroalkyl group in a straight chain or branched chain form, and having less than 10 carbon atoms) ##STR11## (in the above general formulae (3) and (4), R 1 denotes hydrogen or a methyl group; R 2 represents --CH 2 CH 2 ) l H (l is an integer of from 0 to 10), --CH 2 C(CH 2 OH) 3 , ##STR12## ---Glu (Glu is a residual group of glucose), --(CD designates a residual group of cyclodextrin), or ##STR13## (m is an integer of 0 or 1); and n is an integer of from 1 to 4).
Claim 2
Dependent Claim
216 words
A separating agent, consisting essentially of porous particles of a cross-linked copolymer having a porosity in a range of from 0.5 to 3 ml/g and an average particle diameter in a range of from 1 to 2,000 μm, said copolymer being composed essentially of a cross-linking component consisting of alkylene di(meth)acrylate and/or glycerine poly(meth)acrylate; an ester component containing a fluorine compound represented by the following general formulae (1) and/or (2); and a glycerine-derived ester component and/or a polyethylene glycol ester component represented by the following general formulae (3) and/or (4): ##STR10## (in the above general formulae (1) and (2), R 1 denotes hydrogen or a methyl group; X represents a methylene group or a carbonyl group; and Rf designates a fluoroalkyl group in a straight chain or branched chain form, and having less than 10 carbon atoms) ##STR11## (in the above general formulae (3) and (4), R 1 denotes hydrogen or a methyl group; R 2 represents --CH 2 CH 2 ) l H (l is an integer of from 0 to 10), --CH 2 C(CH 2 OH) 3 , ##STR12## ---Glu (Glu is a residual group of glucose), --(CD designates a residual group of cyclodextrin), or ##STR13## (m is an integer of 0 or 1); and n is an integer of from 1 to 4).
Claim 3
Dependent Claim
145 words
A separating agent according to claim 1, consisting essentially of porous cross-linked copolymer particles composed essentially of structural units (a), (b) and (c) represented by the following general formulae: ##STR14## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl group; n is an integer of from 1 to 3; A represents --CH 2 CF 3 , --CH 2 CF 2 CF 2 CF 3 , --COCF 3 , --COCF 2 CF 2 CF 3 , or --CH(CF 3 )CF 3 ; B designates --H, --CH 2 CH 2 OH, --CH 2 CH(OH)CH 2 OH, --CH 2 C(CH 2 OH) 3 , --Glu (Glu is a residual group of glucose, or --CD (CD is a residual group of cyclodextrin); and mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.01 to 0.90, and 0.01 to 0.95, respectively.]
Claim 4
Dependent Claim
160 words
A separating agent according to claim 1, consisting essentially of porous cross-linked copolymer particles composed essentially of structural units (a), (b) and (c) represented by the following general formulae, with the fluorine content in said polymer particles ranging from 1 to 20% by weight, and being useful as a gel-permeation chromatographic carrier: ##STR15## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl group; n is an integer of from 1 to 3; A represents --CH 2 CF 3 , --CH 2 CF 2 CF 2 CF 3 , or --COCF 2 CF 2 CF 3 ; B designates --H, --CH 2 CH 2 OH, --CH 2 CH(OH)CH 2 OH, --CH 2 C(CH 2 OH) 3 , --Glu (Glu is a residual group of glucose), or --CD (CD is a residual group of cyclodextrin); the mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.01 to 0.70, and 0.10 to 0.95, respectively.]
Claim 5
Dependent Claim
120 words
A separating agent according to claim 1, consisting essentially of porous cross-linked copolymer particles composed essentially of structural units (a), (b) and (c) represented by the following general formulae, with the fluorine content in said polymer particles ranging from 10 to 60% by weight, and being useful as an adsorptive separator: ##STR16## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl group; n is an integer of from 1 to 3; A represents --CH(CF 3 )CF 3 ; B designates --H, --CH 2 CH 2 OH, or --CH 2 CH(OH)CH 2 OH; and the mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.10 to 0.90, and 0.01 to 0.70, respectively.]
Claim 6
Dependent Claim
109 words
A separating agent according to claim 1, consisting essentially of porous copolymer particles composed essentially of structural units (a), (b) and (c) represented by the following general formulae: ##STR17## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl; A represents --CH 2 CF 3 , --CH 2 CF 2 CF 2 CF 3 , --COCF 2 CF 2 CF 3 , or --CH(CF 3 )CF 3 ; B designates --H, --CH 2 CH 2 OH, or --CH 2 CH(OH)CH 2 OH; and the mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.01 to 0.90, and 0.01 to 0.95, respectively.]
Claim 7
Dependent Claim
129 words
A separating agent according to claim 1, consisting essentially of porous cross-linked copolymer particles composed essentially of structural units (a), (b) and (c) represented by the following general formulae, with the fluorine content in said polymer particles ranging from 1 to 20% by weight, and being useful as a gel-permeation chromatographic carrier: ##STR18## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl group; A represents --CH 2 CF 3 , --CH 2 CF 2 CF 2 CF 3 , or --COCF 2 CF 2 CF 3 ; B designates --H, --CH 2 CH 2 OH, or --CH 2 CH(OH)CH 2 OH; and the mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.01 to 0.70, and 0.10 to 0.95, respectively.]
Claim 8
Dependent Claim
113 words
A separating agent according to claim 1, consisting essentially of porous cross-linked copolymer particles composed essentially of structural units (a), (b) and (c) to be represented by the following general formulae, with the fluorine content in said polymer particles ranging from 10 to 60% by weight, and being useful as an adsorptive separator: ##STR19## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl group; A designates --CH(CF 3 )CF 3 ; B represents --H, --CH 2 CH 2 OH, or --CH 2 CH(OH)CH 2 OH; and the mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.10 to 0.90, and 0.01 to 0.70, respectively.]
Claim 9
Dependent Claim
90 words
A separating agent according to claim 1, consisting essentially of porous copolymer particles composed essentially of structural units (a), (b) and (c) to be represented by the following general formulae: ##STR20## [in the above general formulae (a), (b) and (c), R 1 denotes hydrogen or a methyl group; n is an integer of from 1 to 3; A represents --COCF 2 CF 2 CF 3 or --COCF 3 ; and the mol fractions of (a), (b) and (c) are 0.01 to 0.55, 0.01 to 0.70, and 0.10 to 0.95, respectively.]
Claim 10
Dependent Claim
34 words
A separating agent according to claim 8, wherein the fluorine content in said porous cross-linked copolymer particles ranges from 1 to 20% by weight, and that it is used as the gel-permeation chromatographic carrier.
Claim 11
Dependent Claim
15 words
A separating agent according to claim 1, characterized in that it is a protein separator.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-09-28 | 1991-03-30 | 1991-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-28 | 1995-03-30 | 1995-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-28 | 1999-03-30 | 1999-09-29 | $7700.00 | Window Closed / Lapsed |