US4694084A
Expired / Lapsed
US
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Glycerol ether phosphatides
Assignee: F Hoffmann La Roche AG
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Filing: 1985-03-08
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Granted: 1987-09-15
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Expires: 2005-03-08
Abstract
Abstract Compounds of the general formula ##STR1## wherein two of the residues R 1 , R 2 and R 3 represent C 10-30 -alkyl residues with at least 8 C-atoms in a straight chain, at least one of these residues being substituted by at least 2 C 1-3 -alkyl residues and the sum of the C-atoms in the two residues being greater than 20; and the third residue is a residue --P(O)(O - )OR 4 in which R 4 represents a lower-alkyl or C 5-7 -cycloalkyl residue which is substituted by a quaternary ammonium group or a C 5-7 -cycloalkyl residue which contains a di-(lower-alkyl)-substituted nitrogen atom, are useful for the manufacture of colloidal solution systems. The compounds of formula I can be prepared starting from glycerol derivatives as described in more detail in the specification.
Inventors
- 👤 Manfred Breuninger
- 👤 Dieter Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:09
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; A; A61; A61K; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; A61K9/127; A61K9/1271; A61K9/1272; C07C; C07C309/00; C07C43/00; C07C43/02; C07C43/03; C07C43/04; C07C43/13; C07C43/135; C07C43/14; C07C43/164; C07D; C07D317/00; C07D317/08; C07D317/10; C07D317/12; C07F9/547; C07F9/553; C07F9/576; C07F9/59
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
103 words
A compound of the formula ##STR6## wherein two of the residues R 1 , R 2 and R 3 represent C 10-30 -alkyl residues with at least 8 C-atoms in a straight chain, at least one of these residues being substituted by at least 2 C 1-3 -alkyl residues and the sum of the C-atoms in the two residues being greater than 20; and the third residue is a residue --P(O)(O - )OR 4 in which R 4 is C 5-7 -cycloalkyl residue which is substituted by a quaternary ammonium group or a C 5--7 -cycloalkyl residue which contains a di-(lower-alkyl)-substituted nitrogen atom.
Claim 2
Dependent Claim
103 words
A compound of the formula ##STR6## wherein two of the residues R 1 , R 2 and R 3 represent C 10-30 -alkyl residues with at least 8 C-atoms in a straight chain, at least one of these residues being substituted by at least 2 C 1-3 -alkyl residues and the sum of the C-atoms in the two residues being greater than 20; and the third residue is a residue --P(O)(O - )OR 4 in which R 4 is C 5-7 -cycloalkyl residue which is substituted by a quaternary ammonium group or a C 5--7 -cycloalkyl residue which contains a di-(lower-alkyl)-substituted nitrogen atom.
Claim 3
Dependent Claim
40 words
A compound in accordance with claim 1, in which R 1 and R 2 represent C 10-30 -alkyl residues with at least 8 C-atoms in a straight-chain, each of which is substituted by at least 2 C 1-3 -alkyl residues.
Claim 4
Dependent Claim
34 words
A compound in accordance with claim 2, wherein two of the residues R 1 , R 2 and R 3 represent residues of the formula ##STR7## wherein n is a whole number of 0--4.
Claim 5
Dependent Claim
26 words
A compound in accordance with claim 3, in which two of the residues R 1 , R 2 and R 3 represent tetrahydrogeranyl, hexahydrofarnesyl or dihydrophytyl.
Claim 6
Dependent Claim
19 words
A compound in accordance with claim 4, in which R 4 is tri-(lower-alkyl)-ammonio-C 5-7 -cycloalkyl or N,N-di-lower-alkyl-C 4-6 -azacycloalkyl.
Claim 7
Dependent Claim
15 words
A compound in accordance with claim 5, in which R 4 is 4-(trimethylammonio)cyclohexyl or N,N-dimethyl-4-piperidyl.
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 1, [(cis/trans)-4-[[[(RS)-2,3-bis[[(3RS,7R,11R)-3,7,11,15-tetramethylhexadecyl]oxy]propoxy]hydroxyphosphinyl]oxy]cyclohexyl]trimethylammonium hydroxide (internal salt).
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-09-14 | 1991-03-16 | 1991-09-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-14 | 1995-03-16 | 1995-09-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-14 | 1999-03-16 | 1999-09-15 | $7700.00 | Window Closed / Lapsed |