US4562005A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Methoxypropyl phosphate derivatives
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1984-03-02
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Granted: 1985-12-31
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Expires: 2004-03-02
Abstract
Abstract Novel phospholipids, inclusive of pharmaceutically acceptable salts thereof, of the formula ##STR1## wherein R 1 is an aliphatic hydrocarbon residue of 15 to 20 carbon atoms, R 2 is an alkyl group of 1 to 4 carbon atoms and R 3 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, exhibit inhibitory activity to multiplication of tumor cells and are useful for inhibiting multiplication of tumor cells and prolonging the survival time of tumor-bearing warm-blooded animal.
Inventors
- 👤 Shoshichi Nojima
- 👤 Hiroaki Nomura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:39
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
57 words
A compound of the formula ##STR13## wherein R 1 is an alkyl, alkenyl or alkynyl group of 15 to 20 carbon atoms, R 2 is an alkyl group of 1 to 4 carbon atoms and R 3 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
57 words
A compound of the formula ##STR13## wherein R 1 is an alkyl, alkenyl or alkynyl group of 15 to 20 carbon atoms, R 2 is an alkyl group of 1 to 4 carbon atoms and R 3 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
22 words
A compound according to claim 1, wherein R 1 is an alkyl, alkenyl or alkynyl group of 15 to 17 carbon atoms.
Claim 4
Dependent Claim
20 words
A compound according to claim 1, wherein R 1 is an alkyl, alkenyl or alkynyl group of 18 carbon atoms.
Claim 5
Dependent Claim
22 words
A compound according to claim 1, wherein R 1 is an alkyl, alkenyl or alkynyl group of 19 or 20 carbon atoms.
Claim 6
Dependent Claim
11 words
A compound according to claim 1, wherein R 1 is n-octadecyl.
Claim 7
Dependent Claim
11 words
A compound according to claim 1, wherein R 2 is methyl.
Claim 8
Dependent Claim
13 words
A compound according to claim 1, wherein R 3 is hydrogen or methyl.
Claim 9
Dependent Claim
7 words
The compound which is 3-octadecyloxy-2-methoxypropyl 2-dimethylaminoethyl phosphate.
Claim 10
Dependent Claim
7 words
The compound which is 3-octadecyloxy-2-methoxypropyl 2-dimethylaminoethyl phosphate.
Claim 11
Dependent Claim
7 words
The compound which is 3-octadecyloxy-2-methoxypropyl 2-methylaminoethyl phosphate.
Claim 12
Dependent Claim
7 words
The compound which is 3-octadecyloxy-2-methoxypropyl 2-methylaminoethyl phosphate.
Claim 13
Dependent Claim
10 words
The compound of claim 1 which is (2S)-3-octadecyloxy-2-methoxypropyl 2-dimethylaminoethyl phosphate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-30 | 1989-07-01 | 1989-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-30 | 1993-07-01 | 1993-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-30 | 1997-07-01 | 1997-12-31 | $7700.00 | Window Closed / Lapsed |