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US4693718A Expired / Lapsed US ⏱️ 0.0 years remaining

Stimulation of chemotaxis by chemotactic peptides

Assignee: UAB RESEARCH FOUNDATION NON-PROFIT CORP
•
Filing: 1985-10-31
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Granted: 1987-09-15
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Expires: 2005-10-31
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Abstract

Abstract A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formula B1-X-(AGVPGFGVG)n-Y-B2 wherein A is a peptide-forming residue of L-alanine: P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; F is a peptide-forming residue of L-phenylalanine; B1 is H or a biocompatible N-terminal group; B2 is OH, OB3 where B3 is a non-toxic metal ion, or a biocompatible C-terminal group: X is GVPGFGVG, VPGFGVG, PGFGVG, GFGVG, FGVG, GVG, VG, G or a covalent bond; Y is AGVPGFGV, AGVPGFG, AGVPGF, AGVPG, AGVP, AGV, AG, A or a covalent bond; and n is an integer from 1 to 100; into a surface of the prosthetic device. Prosthetic devices which have the property of enhancing invasion of elastic fiber synthesizing fibroblasts as a result of the chemotactic peptide are also disclosed.

Inventors

  • 👤 Dan W. Urry
  • 👤 Marianna M. Long

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 21:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/50; A61L27/54; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61K; A61K38/00; A61L2300/00; A61L2300/20; A61L2300/252

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 124 words
A prosthetic device wherein a surface of said device has a chemotactic peptide of the formula B.sup.1 -X-(AGVPGFGVG).sub.n -Y-B.sup.2 wherein A is a peptide-forming residue of L-alanine: P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; F is a peptide-forming residue of L-phenylalanine; B 1 is H or a biocompatible N-terminal group; B 2 is OH, OB 3 where B 3 is a non-toxic metal ion, or a biocompatible C-terminal group: X is GVPGFGVG, VPGFGVG, PGFGVG, GFGVG, FGVG, GVG, VG, G or a covalent bond; Y is AGVPGFGV, AGVPGFG, AGVPGF, AGVPG, AGVP, AGV, AG, A or a covalent bond; and n is an interger from 1 to 100; incorporated into said surface.
Claim 2
Dependent Claim 124 words
A prosthetic device wherein a surface of said device has a chemotactic peptide of the formula B.sup.1 -X-(AGVPGFGVG).sub.n -Y-B.sup.2 wherein A is a peptide-forming residue of L-alanine: P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; F is a peptide-forming residue of L-phenylalanine; B 1 is H or a biocompatible N-terminal group; B 2 is OH, OB 3 where B 3 is a non-toxic metal ion, or a biocompatible C-terminal group: X is GVPGFGVG, VPGFGVG, PGFGVG, GFGVG, FGVG, GVG, VG, G or a covalent bond; Y is AGVPGFGV, AGVPGFG, AGVPGF, AGVPG, AGVP, AGV, AG, A or a covalent bond; and n is an interger from 1 to 100; incorporated into said surface.
Claim 3
Dependent Claim 12 words
The device of claim 1, wherein n is from 1 to 10.
Claim 4
Dependent Claim 10 words
The device of claim 1, wherein n is about 5.
Claim 5
Dependent Claim 9 words
The device of claim 1, wherein n is 1.
Claim 6
Dependent Claim 15 words
The device of claim 1, wherein said peptide is H-AGVPGFGVG-OH, H-GFGVGAGVP-OH, or a salt thereof.
Claim 7
Dependent Claim 26 words
The device of claim 1, wherein B 1 is H and B 2 is OH or OB 3 where B 3 is an alkali metal ion.
Claim 8
Dependent Claim 28 words
The device of claim 1, wherein said amount is from 10 -9 to 10 -3 millimols of nonamer or repeating unit per 100 cm 2 of said surface.
Claim 9
Dependent Claim 13 words
The device of claim 1, wherein said prosthetic device comprises a structural polypeptide.
Claim 10
Dependent Claim 21 words
The device of claim 1, wherein said chemotactic peptide is incorporated using non-covalent bonding between said chemotactic peptide and said surface.
Claim 11
Dependent Claim 12 words
The device of claim 1, wherein said surface comprises a structural peptide.

References Cited (Backward Citations)

US4605413A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1990-09-14 1991-03-16 1991-09-15 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1994-09-14 1995-03-16 1995-09-15 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1998-09-14 1999-03-16 1999-09-15 $7700.00 Window Closed / Lapsed

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