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US4692403A
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Methods and compositions for the detection of acquired immune deficiency syndrome
Assignee: Texas A&M University System
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Filing: 1984-11-28
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Granted: 1987-09-08
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Expires: 2004-11-28
Abstract
Abstract An immunoreagent useful to diagnose Acquired Immune Deficiency Syndrome (AIDS) is provided. The immunoreagent comprises tracer tagged antibodies which are selectively reactive with lymphoid cells of AIDS infected tissue. The antibodies are obtained from marmoset monkeys which are either afflicted with or have recovered from Marmoset wasting syndrome. The immunoreagent is employed in a method to diagnose AIDS in a suspected carrier. The method involves admixing the immunoreagent such as marmoset serum or purified immunoglobulins together with lymphoid tissue samples taken from the suspected carrier. After incubating the admixture under appropriate conditions favorable for the formation of an immune complex, the samples are assayed for a positive immune reaction.
Inventors
- 👤 Luther E. Lindner
- 👤 Stephen R. Wechter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:37
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56966; G01N33/56972; Y; Y10; Y10S; Y10S435/00; Y10S435/968; Y10S435/974; Y10S436/00; Y10S436/804; Y10S436/811; Y10S436/813
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
83 words
A method of immunodiagnosing Acquired Immune Deficiency Syndrome in a suspected carrier comprising: (a) admixing a lymphoid cell sample obtained from the suspected carrier with an immunoreagent comprising tracer tagged antibodies selectively reactive with AIDS infected tissue, said antibodies obtained from marmoset monkeys, wherein the marmoset monkeys are either afflicted with or have recovered from marmoset wasting syndrome; (b) incubating the admixture under conditions to form an immune complex; and (c) detecting a positive immunoreaction which is indicative of Acquired Immune Deficiency Syndrome.
Claim 2
Independent Claim
83 words
A method of immunodiagnosing Acquired Immune Deficiency Syndrome in a suspected carrier comprising: (a) admixing a lymphoid cell sample obtained from the suspected carrier with an immunoreagent comprising tracer tagged antibodies selectively reactive with AIDS infected tissue, said antibodies obtained from marmoset monkeys, wherein the marmoset monkeys are either afflicted with or have recovered from marmoset wasting syndrome; (b) incubating the admixture under conditions to form an immune complex; and (c) detecting a positive immunoreaction which is indicative of Acquired Immune Deficiency Syndrome.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein the suspected carrier is a human.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the lymphoid cell sample is blood.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein the lymphoid cell sample is lymphatic tissue.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein the lymphoid cell sample is splenic tissue.
Claim 7
Dependent Claim
10 words
The method of claim 1 wherein the immunoreagent is serum.
Claim 8
Dependent Claim
12 words
The method of claim 1 wherein the immunoreagent consists essentially of immunoglobulins.
Claim 9
Dependent Claim
15 words
The method of claim 1 wherein the tracer tagged antibodies are covalently linked to biotin.
Claim 10
Dependent Claim
24 words
The method of claim 1 wherein the tracer tagged antibodies comprise antibody covalently linked to a radioisotope, a fluorogenic enzyme, or a fluorescent label.
Claim 11
Dependent Claim
40 words
An immunoreagent useful to diagnose Acquired Immune Deficiency Syndrome, comprising tracer tagged antibodies selectively reactive with AIDS infected tissue, said antibodies obtained from marmoset monkeys, wherein the marmoset monkeys are either afflicted with or have recovered from marmoset wasting syndrome.
Claim 12
Dependent Claim
40 words
An immunoreagent useful to diagnose Acquired Immune Deficiency Syndrome, comprising tracer tagged antibodies selectively reactive with AIDS infected tissue, said antibodies obtained from marmoset monkeys, wherein the marmoset monkeys are either afflicted with or have recovered from marmoset wasting syndrome.
Claim 13
Dependent Claim
16 words
The immunoreagent of claim 10 wherein the tracer tagged antibodies comprise antibody covalently linked to biotin.
Claim 14
Dependent Claim
24 words
The immunoreagent of claim 10 wherein the tracer tagged antibodies comprise antibody covalently linked to a radioisotope, a fluorogenic enzyme, or a fluorescent moiety.
References Cited (Backward Citations)
US4298685A
Cited
US4520113A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-09-07 | 1991-03-09 | 1991-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-07 | 1995-03-09 | 1995-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-07 | 1999-03-09 | 1999-09-08 | $7700.00 | Window Closed / Lapsed |