US4689567A
Expired / Lapsed
US
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NMR Fourier imaging from multiple echoes
Assignee: Advanced NMR Systems Inc
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Filing: 1986-02-04
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Granted: 1987-08-25
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Expires: 2006-02-04
Abstract
Abstract Fourier images based on multiple NMR echoes may be obtained using the method and apparatus disclosed. A sequence of pulses and gradients are applied to the object to be imaged. The pulses begin with an excitation pulse, which is followed by a series of refocusing pulses. In order to compensate for phase error in the refocusing pulses, the refocusing pulses are applied along alternating X and Y axes in the rotating frame of reference. The echoes are then coherently added to reserve phase information. Alternate echoes may be time reversed and their complex conjugate may be taken to permit coherent addition. Alternatively, the even echoes may be added separately from the odd echoes to produce separate data sets. The pulse and gradient switching sequence provides sign reversals such that any baseline component will be cancelled by the coherent addition. Before or after coherent addition, the echoes are transformed, and after forming a combined data set from a series of echo sequences, the combined data set is again transformed to produce an image of the object.
Inventors
- 👤 Andrew Maudsley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:15
CPC Classifications
G; G01; G01N; G01N24/00; G01N24/08; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/561; G01R33/5615; G01R33/5617; G01R33/565; G01R33/56563
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
142 words
A method of generating an NMR image of an object, comprising: applying a sequence of stimulating signals to an object in such a manner as to produce a plurality of groups of echoing NMR signals with both real and imaginary components containing phase encoded information; adding the echoing NMR signals of each of said plurality of groups of echoing NMR signals to obtain a respective data set for each group, the adding step including preserving the phase encoded information from both the real and imaginary components of the echoing NMR signals; combining the respective data sets to obtain a combined data set including the phase encoded information from both the real and imaginary components of the echoing NMR signals of each respective data set; and performing a phase-dependent transform of the combined data set to obtain an NMR image of the object.
Claim 2
Independent Claim
142 words
A method of generating an NMR image of an object, comprising: applying a sequence of stimulating signals to an object in such a manner as to produce a plurality of groups of echoing NMR signals with both real and imaginary components containing phase encoded information; adding the echoing NMR signals of each of said plurality of groups of echoing NMR signals to obtain a respective data set for each group, the adding step including preserving the phase encoded information from both the real and imaginary components of the echoing NMR signals; combining the respective data sets to obtain a combined data set including the phase encoded information from both the real and imaginary components of the echoing NMR signals of each respective data set; and performing a phase-dependent transform of the combined data set to obtain an NMR image of the object.
Claim 3
Dependent Claim
20 words
The method of claim 1, in which the combining step comprises cancelling any baseline offsets of the echoing NMR signals.
Claim 4
Dependent Claim
26 words
The method of claim 1 in which the applying step comprises the substeps of applying an excitation pulse and then applying a sequence of refocusing pulses.
Claim 5
Dependent Claim
32 words
The method of claim 3 in which the substep of applying the sequence of refocusing pulses comprises applying refocusing pulses having non-ideal characteristics and compensating for the non-ideal characteristics of the pulses.
Claim 6
Dependent Claim
41 words
The method of claim 4 in which compensating for the non-ideal characteristics of the pulses comprises repeating a subsequence of four refocusing pulses, each repetition of the subsequence comprising applying the four refocusing pulses alternately along first and second orthogonal axes.
Claim 7
Dependent Claim
30 words
The method of claim 3 in which the substep of applying the excitation pulse further comprises applying a gradient field to select a plane of the object to be imaged.
Claim 8
Dependent Claim
41 words
The method of claim 3 in which each of the refocusing pulses produces one of the echoing NMR signals, the adding step comprising adding the echoing NMR signals from the refocusing pulses following the excitation pulse to obtain a combined signal.
Claim 9
Dependent Claim
22 words
The method of claim 7 in which the adding step further comprises transforming the combined signal to obtain a respective data set.
Claim 10
Dependent Claim
98 words
The method of claim 8 in which the applying step further comprises applying a plurality of excitation pulses like the first-mentioned excitation pulse and including the first-mentioned excitation pulse, the applying step further comprising applying a respective sequence of refocusing pulses like the first-mentioned sequence of refocusing pulses after each excitation pulse; the adding step further comprising adding the echoing NMR signals from each respective sequence of refocusing pulses to obtain a respective combined signal like the first-mentioned combined signal and transforming each respective combined signal to obtain a respective data set like the first-mentioned respective data set.
Claim 11
Dependent Claim
111 words
The method of claim 8 in which the applying step further comprises applying a plurality of excitation pulses like the first-mentioned excitation pulse and including the first-mentioned excitation pulse, the applying step further comprising applying a respective sequence of refocusing pulses like the first-mentioned sequence of refocusing pulses after each excitation pulse; the adding step further comprising adding the echoing NMR signals from at least two of the sequences of refocusing pulses to obtain a respective combined signal like the first-mentioned combined signal, the respective combined signal being averaged; the adding step further comprising transforming each respective combined signal to obtain a respective data set like the first-mentioned respective data set.
Claim 12
Dependent Claim
54 words
The method of claim 7 in which the substep of adding the echoing NMR signals comprises obtaining a time reversed signal of each alternative one of the echoing NMR signals, obtaining a complex conjugate signal of each of the time reversed signals, and adding each complex conjugate signal to the preceding echoing NMR signal.
Claim 13
Independent Claim
172 words
An apparatus for generating an NMR image of an object comprising: applying means for applying stimulating signals to an object, the applying means being operable for applying a sequence of stimulating signals to the object for producing a plurality of groups of echoing NMR signals from both real and imaginary components of the echoing NMR signals containing phase encoded information; adding means for adding the echoing NMR signals of each of said groups of echoing NMR signals in such a manner as to obtain a respective data set for each group, the adding means also being for preserving the phase encoded information from both the real and imaginary components of the echoing NMR signals; combining means for combining the respective data sets for obtaining a combined data set including the phase encoded information from both the real and imaginary components of the echoing NMR signals of each respective data set; and a transforming means for performing a phase-dependent transform on the combined data set for providing an NMR image of the object.
Claim 14
Independent Claim
172 words
An apparatus for generating an NMR image of an object comprising: applying means for applying stimulating signals to an object, the applying means being operable for applying a sequence of stimulating signals to the object for producing a plurality of groups of echoing NMR signals from both real and imaginary components of the echoing NMR signals containing phase encoded information; adding means for adding the echoing NMR signals of each of said groups of echoing NMR signals in such a manner as to obtain a respective data set for each group, the adding means also being for preserving the phase encoded information from both the real and imaginary components of the echoing NMR signals; combining means for combining the respective data sets for obtaining a combined data set including the phase encoded information from both the real and imaginary components of the echoing NMR signals of each respective data set; and a transforming means for performing a phase-dependent transform on the combined data set for providing an NMR image of the object.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-24 | 1991-02-23 | 1991-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-24 | 1995-02-23 | 1995-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-24 | 1999-02-23 | 1999-08-25 | $7700.00 | Window Closed / Lapsed |