US4570119A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for visualization of in-plane fluid flow by proton NMR imaging
Assignee: General Electric Co
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Filing: 1983-11-15
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Granted: 1986-02-11
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Expires: 2003-11-15
Abstract
Abstract A method for visualizing in-plane flow utilizing an NMR pulse sequence to produce a plurality of odd and even spin-echo signals occurring respectively at echo delay times, T E , of 2τ, 6τ, 10τ, etc., and 4τ, 8τ, 12τ, etc. In the preferred embodiment, a fictitious spin-echo amplitude is calculated from the odd and even spin-echo signals at an echo delay time T E =0, for example. The calculated values for the odd spin-echo signals are lower than those calculated for the even spin-echo signals due to incomplete rephasing of the odd spin-echo signals in the presence of a read-out magnetic field gradient and flow. Subtraction of the calculated image pixel value of the odd spin-echo signals from the calculated pixel values of the even spin-echo signals results in a difference image which highlights the flowing nuclear spins. The image pixels due to stationary nuclear spins experience exact cancellation.
Inventors
- 👤 Felix W. Wehrli
- 👤 James R. MacFall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:39
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/563; G01P; G01P5/00; G01P5/001
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
233 words
A method of imaging nuclear spin flow in a predetermined object region, which region is positioned in a homogeneous magnetic field, the flow within the region having a velocity component in the direction of a read-out magnetic field gradient, said method comprising: (a) exciting to resonance a plurality of nuclear spins in the predetermined region of said object; (b) subjecting said excited nuclear spins to a phase-encoding magnetic field gradient having a plurality of programmable amplitude-duration products; (c) causing said excited nuclear spins to produce a plurality of even and odd numbered spin-echo signals, the odd numbered ones of said spin-echo signals having reduced amplitudes relative to even-numbered ones of said spin-echo signals due to flow in the presence of the read-out magnetic field gradient; (d) sampling said spin-echo signals in the presence of the read-out gradient; (e) repeating, in the course of a complete scan of said predetermined region, steps (a)-(d) a number of times equal to the plurality of programmable amplitude-duration products of said phase-encoding gradient; (f) Fourier analyzing said even and odd spin-echo signals to generate corresponding even and odd image pixel data arrays; (g) combining corresponding image pixel data in the even and odd pixel arrays to eliminate image contributions due to stationary nuclear spins, leaving substantially only signal contributions due to flowing nuclear spins in the predetermined region; and (h) displaying pixel data corresponding to flowing nuclear spins.
Claim 2
Independent Claim
233 words
A method of imaging nuclear spin flow in a predetermined object region, which region is positioned in a homogeneous magnetic field, the flow within the region having a velocity component in the direction of a read-out magnetic field gradient, said method comprising: (a) exciting to resonance a plurality of nuclear spins in the predetermined region of said object; (b) subjecting said excited nuclear spins to a phase-encoding magnetic field gradient having a plurality of programmable amplitude-duration products; (c) causing said excited nuclear spins to produce a plurality of even and odd numbered spin-echo signals, the odd numbered ones of said spin-echo signals having reduced amplitudes relative to even-numbered ones of said spin-echo signals due to flow in the presence of the read-out magnetic field gradient; (d) sampling said spin-echo signals in the presence of the read-out gradient; (e) repeating, in the course of a complete scan of said predetermined region, steps (a)-(d) a number of times equal to the plurality of programmable amplitude-duration products of said phase-encoding gradient; (f) Fourier analyzing said even and odd spin-echo signals to generate corresponding even and odd image pixel data arrays; (g) combining corresponding image pixel data in the even and odd pixel arrays to eliminate image contributions due to stationary nuclear spins, leaving substantially only signal contributions due to flowing nuclear spins in the predetermined region; and (h) displaying pixel data corresponding to flowing nuclear spins.
Claim 3
Dependent Claim
72 words
The method of claim 1 wherein said step of combining comprises the step of extrapolating the actual pixel data derived from the odd-numbered spin-echo signals and extrapolating the actual pixel data derived from the even-numbered spin-echo signals to a predetermined spin-echo time T E , such that the combination of the extrapolated pixel values results in difference pixel values highlighting flowing nuclear spins, while stationary nuclear spin pixel data is substantially cancelled.
Claim 4
Dependent Claim
17 words
The method of claim 2 wherein said step of combining comprises subtracting the extrapolated image pixel data.
Claim 5
Dependent Claim
17 words
The method of claim 3 wherein said predetermined spin-echo time is selected such that T E =0.
Claim 6
Dependent Claim
17 words
The method of claim 3 wherein said predetermined spin-echo time is selected such that T E ≠0.
Claim 7
Dependent Claim
44 words
The method of claim 3 wherein said step of exciting comprises irradiating said object with a selective RF pulse in the presence of a magnetic field gradient so as to excite nuclear spins substantially in the predetermined region, including any nuclear spins flowing therein.
Claim 8
Dependent Claim
15 words
The method of claim 6 wherein said RF pulse comprises a selective 90° RF pulse.
Claim 9
Dependent Claim
22 words
The method of claim 6 wherein said phase-encoding gradient is applied in a direction orthogonal to the direction of the read-out gradient.
Claim 10
Dependent Claim
35 words
The method of claim 8 wherein said step (c) for producing a plurality of spin-echo signals comprises irradiating said region with a plurality of 180° RF pulses applied in the direction of said phase-encoding gradient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-10 | 1989-08-12 | 1990-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-10 | 1993-08-12 | 1994-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-10 | 1997-08-12 | 1998-02-11 | $7700.00 | Window Closed / Lapsed |