US4471306A
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Method of NMR imaging which overcomes T2 * effects in an inhomogeneous static magnetic field
Assignee: General Electric Co
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Filing: 1982-02-03
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Granted: 1984-09-11
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Expires: 2002-02-03
Abstract
Abstract The T 2 * effects due to inherent inhomogeneities in the static magnetic field are overcome by the use of a 180° RF pulse to produce a nuclear spin echo suitable for obtaining spatial information and by the adjustment of the pulsed gradients such that the occurrence of the spin echo due to the applied gradients coincides with the occurrence of the nuclear spin echo derived from the rephasing of spins in the presence of the inhomogeneities inherent in the main static magnetic field. The 180° RF pulse is applied with the imaging gradients turned off so that long RF pulse lengths can be used, thus reducing RF power requirements. Exemplary applications of the pulse method to multiple angle projection reconstruction and two-dimensional Fourier transform (spin warp imaging) imaging techniques are also described.
Inventors
- 👤 William A. Edelstein
- 👤 Paul A. Bottomley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:28
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/565; G01R33/56563
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
270 words
A method for NMR image formation which overcomes the effects of inherent static magnetic field inhomogeneity on nuclear spin echo formation, said method comprising the steps of: a. maintaining a static magnetic field along a first axis of a sample; b. irradiating said sample with a frequency selective RF pulse so as to excite a plurality of nuclear spins in a predetermined region within said sample; c. applying, for a first predetermined time interval, at least partially coextensive with said frequency selective RF pulse, at least one dephasing magnetic field gradient along a second axis of said sample to dephase said excited nuclear spins, said dephasing being in addition to nuclear spin dephasing induced by inherent inhomogeneities in said static magnetic field; d. irradiating said sample during a second predetermined time at a predetermined elapse time interval τ a subsequent to the mean occurrence of said frequency selective RF pulse, with a 180° RF pulse so as to initiate the rephasing of said excited nuclear spins; e. applying, during a third predetermined time interval, subsequent to said second time interval, at least one rephasing gradient having the same direction as said dephasing gradient such that, at an interval of time equal to said interval τ a following said 180° RF pulse, the nuclear spin echo caused by rephasing of the nuclear spins dephased by said dephasing gradient coincides with the occurrence of the nuclear spin echo derived from the rephasing of the nuclear spins dephased by the inherent inhomogeneities in said static magnetic field, said nuclear spin echoes producing a composite NMR signal; and f. detecting said composite NMR signal.
Claim 2
Independent Claim
270 words
A method for NMR image formation which overcomes the effects of inherent static magnetic field inhomogeneity on nuclear spin echo formation, said method comprising the steps of: a. maintaining a static magnetic field along a first axis of a sample; b. irradiating said sample with a frequency selective RF pulse so as to excite a plurality of nuclear spins in a predetermined region within said sample; c. applying, for a first predetermined time interval, at least partially coextensive with said frequency selective RF pulse, at least one dephasing magnetic field gradient along a second axis of said sample to dephase said excited nuclear spins, said dephasing being in addition to nuclear spin dephasing induced by inherent inhomogeneities in said static magnetic field; d. irradiating said sample during a second predetermined time at a predetermined elapse time interval τ a subsequent to the mean occurrence of said frequency selective RF pulse, with a 180° RF pulse so as to initiate the rephasing of said excited nuclear spins; e. applying, during a third predetermined time interval, subsequent to said second time interval, at least one rephasing gradient having the same direction as said dephasing gradient such that, at an interval of time equal to said interval τ a following said 180° RF pulse, the nuclear spin echo caused by rephasing of the nuclear spins dephased by said dephasing gradient coincides with the occurrence of the nuclear spin echo derived from the rephasing of the nuclear spins dephased by the inherent inhomogeneities in said static magnetic field, said nuclear spin echoes producing a composite NMR signal; and f. detecting said composite NMR signal.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein said frequency selective RF pulse comprises a Gaussian amplitude-modulated carrier.
Claim 4
Dependent Claim
27 words
The method of claim 1 wherein said frequency selective RF pulse comprises a carrier modulated by (sin bt)/bt, wherein b is a constant and t is time.
Claim 5
Independent Claim
21 words
The method of one of claims 1, 2, or 3 wherein said selective RF pulses comprises a selective 90° RF pulse.
Claim 6
Dependent Claim
18 words
The method of claim 4 wherein said dephasing magnetic field gradient comprises a rectangularly shaped time dependent pulse.
Claim 7
Dependent Claim
16 words
The method of claim 4 wherein said dephasing magnetic field gradient comprises one-half of a sinusoid.
Claim 8
Dependent Claim
18 words
The method of claim 4 wherein said dephasing magnetic field gradient comprises a Gaussian shaped time dependent pulse.
Claim 9
Dependent Claim
18 words
The method of claim 1, wherein said predetermined region of excited nuclear spins comprises a thin planar slab.
Claim 10
Dependent Claim
20 words
The method of claim 8 wherein said thin planar slab is situated orthogonal to said first axis of said sample.
Claim 11
Dependent Claim
46 words
The method of claim 8 or 9 wherein said dephasing gradient is a resultant dephasing gradient of the vectorial addition of two constituent dephasing gradients with are mutally orthogonal and which are coplanar with said thin planar slab, said resultant dephasing gradient having a predetermined direction.
Claim 12
Dependent Claim
77 words
The method of claim 10 wherein said rephasing gradient is a resultant rephasing gradient of the vectorial addition of two constituent rephasing gradients which are mutually orthogonal and which are coplanar with said thin planar slab, said constituent rephasing gradients having the same respective directions within said thin planar slab as said constituent dephasing gradients, said constituent rephasing gradients being selected such that said resultant rephasing gradient has the same predetermined direction as said resultant dephasing gradient.
Claim 13
Dependent Claim
57 words
The method of claim 11 wherein the integral of the waveform of said resultant dephasing gradient with respect to time over said first time interval is selected to be equal to the integral of the waveform of said resultant rephasing gradient with respect to time over a time interval equal to said time interval τ a .
Claim 14
Dependent Claim
26 words
The method of claim 12 wherein said resultant rephasing gradient is selected to exhibit a constant amplitude during the step of detecting said composite NMR signal.
Claim 15
Dependent Claim
41 words
The method of claim 13 further comprising the step of repeating the sequence of steps a-f for different directions of said resultant dephasing and rephasing gradients so as to cover, incrementally, at least a 180° arc within said thin planar slab.
Claim 16
Dependent Claim
36 words
The method of claim 14 further comprising the steps of repeating for each direction of said resultant dephasing and rephasing gradients the sequence of steps a-f at a repetition period of between 0.03 and 3 seconds.
Claim 17
Dependent Claim
20 words
The method of claim 15 wherein said repetition period is selected to be between about 0.1 and about 1 second.
Claim 18
Dependent Claim
29 words
The method of claim 14 further comprising the step of irradiating said sample with a 180° RF pulse at about 0.03 and about 3 seconds priod to step b.
Claim 19
Dependent Claim
51 words
The method of claim 17 further comprising the step of repeating the sequence of steps a-f, including irradiating said sample with said 180° RF pulse prior to step b, for each direction of said resultant dephasing and rephasing gradients at a repetition period of between about 0.03 and about 3 seconds.
Claim 20
Dependent Claim
42 words
The method of claim 14 wherein said predetermined time interval τ a between said frequency selective RF pulse in step b and said 180° RF pulse in step d is selected from a range of between about 2 and about 1500 milliseconds.
Claim 21
Dependent Claim
49 words
The method of claim 19 further comprising the step of repeating said sequence of steps a-f, including said step of selecting said time interval τ a , for each direction of said resultant dephasing and rephasing gradients at a repetition period of between about 0.03 and about 3 seconds.
Claim 22
Dependent Claim
33 words
The method of claim 19 further comprising the step of irradiating said sample with a 180° RF pulse at a time of between about 0.03 and about 3 seconds prior to step b.
Claim 23
Dependent Claim
52 words
The method of claim 21 further comprising the step of repeating the sequence of steps a-f, including said step of irradiating said sample with a 180° RF pulse prior to step b, for each direction of said resultant dephasing and rephasing gradients at a repetition period of between 0.03 and 3 seconds.
Claim 24
Dependent Claim
48 words
The method of claim 8 or 9 wherein said dephasing gradient is the resultant of the vectorial addition of first and second mutually orthogonal gradients which are coplanar with said thin planar slab, said first gradient being amplitude-adjustable for phase encoding nuclear spin information in the direction thereof.
Claim 25
Dependent Claim
17 words
The method of claim 23 wherin said rephasing gradient has the same direction as said second gradient.
Claim 26
Dependent Claim
55 words
The method of claim 24 wherein the integral of the waveform of said second gradient with respect to time over said first time interval is selected to be equal to the integral of the waveform of said rephasing gradient with respect to time over a time interval equal to said time interval τ a .
Claim 27
Dependent Claim
25 words
The method of claim 25 wherein said rephasing gradient is selected to have a constant amplitude during the step of detecting said composite NMR signal.
Claim 28
Dependent Claim
24 words
The method of claim 26 further comprising the step of repeating the sequence of steps a-f for a different amplitude of said first gradient.
Claim 29
Dependent Claim
35 words
The method of claim 27 further comprising the step of repeating the sequence of steps a-f for each amplitude of said first gradient at a repetition period of between about 0.3 and about 3 seconds.
Claim 30
Dependent Claim
20 words
The method of claim 28 wherein said repetition period is selected to be between about 0.1 and about 1 second.
Claim 31
Dependent Claim
33 words
The method of claim 27 further comprising the step of irradiating said sample with a 180° RF pulse at a time of between about 0.03 and about 3 seconds prior to step b.
Claim 32
Dependent Claim
48 words
The method of claim 30 further comprising the step of repeating the sequence of steps a-f, including irradiating said sample with said 180° RF pulse prior to step b, for each amplitude of said first gradient at a repetition period of between about 0.03 and about 3 seconds.
Claim 33
Dependent Claim
42 words
The method of claim 27 wherein said predetermined time interval τ a between said frequency selective RF pulse in step b and said 180° RF pulse in step d is selected from a range of between about 2 and about 1500 milliseconds.
Claim 34
Dependent Claim
46 words
The method of claim 32 further comprising the step of repeating said sequence of steps a-f, including said step of selecting said time interval τ a , for each amplitude of said first gradient at a repetition period of between about 0.03 and about 3 seconds.
Claim 35
Dependent Claim
33 words
The method of claim 32 further comprising the step of irradiating said sample with a 180° RF pulse at a time of between about 0.03 and about 3 seconds prior to step b.
Claim 36
Dependent Claim
49 words
The method of claim 34 further comprising the step of repeating the sequence of steps a-f, including said step of irradiating said sample with a 180° RF pulse prior to step b for each amplitude of said first gradient at a repetition period of between 0.03 and 3 seconds.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-11 | 1988-03-12 | 1988-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-11 | 1992-03-12 | 1992-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-11 | 1996-03-12 | 1996-09-11 | $7700.00 | Window Closed / Lapsed |