Patent US4686269A successfully refreshed from Google Patents.
US4686269A
Expired / Lapsed
US
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Packing material for liquid chromatography and method for the preparation thereof
Assignee: Tosoh Corp
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Filing: 1985-12-26
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Granted: 1987-08-11
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Expires: 2005-12-26
Abstract
Abstract A packing material for liquid chromatography comprising monovinyl aromatic monomer and divinyl or polyvinyl aromatic monomer is disclosed, wherein, in gel permeation chromatography, exclusion limit molecular weight is not less than 1x103 in terms of standard polystyrene, average particle diameter lies within a rage of 0.5 to 50 mu m and the constitution rate of divinyl or polyvinyl aromatic monomer in copolymer particles is not less than 60% by weight, and a method for the preparation thereof is claimed, wherein suspension polymerization is carried out in a mixed aqueous solution containing organic colvent which dissolves whole monomer containing not less than 60% by weight of divinyl or polyvinyl aromatic monomer in whole monomer by amounts of 50 to 300% by weight of the solvent to both monomers and does not dissolve the copolymer of these monomers and radical polymerization initiator.
Inventors
- 👤 Kuniyuki Tokunaga
- 👤 Tsutomu Hashimoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:29
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/22; B01J20/26; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
154 words
A method for the preparation of the packing material for liquid chromatography comprising a copolymer of a monovinyl aromatic monomer and a divinyl or polyvinyl aromatic monomer, wherein, in gel permeation chromatography characterized in that, upon the copolymerization of monovinyl aromatic monomer with divinyl or polyvinyl aromatic monomer, suspension polymerization is carried out in a mixed aqueous solution containing organic solvent which dissolves whole monomer containing not less than 60% by weight of divinyl or polyvinyl aromatic monomer in whole monomer by amounts of 50 to 300% by weight of solvent to both monomers and does not dissolve the copolymer of these monomers and radical polymerization initiator, exclusion limit molecular weight is not less than 1×10 3 in terms of standard polystyrene, average particle diameter lies within a range of 0.5 to 50 m and the constitution rate of divinyl or polyvinyl aromatic monomer in copolymer particles is not less than 60% by weight.
Claim 2
Independent Claim
154 words
A method for the preparation of the packing material for liquid chromatography comprising a copolymer of a monovinyl aromatic monomer and a divinyl or polyvinyl aromatic monomer, wherein, in gel permeation chromatography characterized in that, upon the copolymerization of monovinyl aromatic monomer with divinyl or polyvinyl aromatic monomer, suspension polymerization is carried out in a mixed aqueous solution containing organic solvent which dissolves whole monomer containing not less than 60% by weight of divinyl or polyvinyl aromatic monomer in whole monomer by amounts of 50 to 300% by weight of solvent to both monomers and does not dissolve the copolymer of these monomers and radical polymerization initiator, exclusion limit molecular weight is not less than 1×10 3 in terms of standard polystyrene, average particle diameter lies within a range of 0.5 to 50 m and the constitution rate of divinyl or polyvinyl aromatic monomer in copolymer particles is not less than 60% by weight.
Claim 3
Dependent Claim
74 words
A packing material for liquid chromatography, comprising a copolymer of a monovinyl aromatic compound and a divinyl or polyvinyl aromatic compound, wherein said divinyl or polyvinyl aromatic compound comprises an amount not less than 60 wt. % of said copolymer, the exclusion limit molecular weight in gel permeation chromatography is not less than 1×10 3 in terms of standard polystyrene, and the average particle diameter lies within a range of 0.5 to 500 μm.
Claim 4
Dependent Claim
74 words
A packing material for liquid chromatography, comprising a copolymer of a monovinyl aromatic compound and a divinyl or polyvinyl aromatic compound, wherein said divinyl or polyvinyl aromatic compound comprises an amount not less than 60 wt. % of said copolymer, the exclusion limit molecular weight in gel permeation chromatography is not less than 1×10 3 in terms of standard polystyrene, and the average particle diameter lies within a range of 0.5 to 500 μm.
Claim 5
Dependent Claim
27 words
The packing material of claim 2, wherein said exclusion limit molecular weight in gel permeation chromatography is 1×10 3 to 4×10 8 in terms of standard polystyrene.
Claim 6
Dependent Claim
20 words
The packing material of claim 2, wherein the average particle diameter lies within a range of 1 to 10 μm.
Claim 7
Dependent Claim
20 words
The packing material of claim 2, wherein the average particle diameter lies within a range of 2 to 10 μm.
Claim 8
Dependent Claim
28 words
The packing material according to claim 2, wherein said divinyl or polyvinyl aromatic compound is present in an amount not less than 80 wt. % to said copolymer.
Claim 9
Dependent Claim
28 words
The packing material of claim 2, wherein said divinyl or polyvinyl aromatic compound is present in an amount of not less than 90 wt. % to said copolymer.
Claim 10
Dependent Claim
17 words
The packing material of claim 2, wherein said divinyl or polyvinyl aromatic compound is para- or meta-dinvinylbenzene.
Claim 11
Dependent Claim
15 words
The packing material of claim 2, wherein said monovinyl aromatic compound is styrene or ethylvinylbenzene.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-10 | 1991-02-09 | 1991-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-10 | 1995-02-09 | 1995-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-10 | 1999-02-09 | 1999-08-11 | $7700.00 | Window Closed / Lapsed |