US4684657A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Benzenesulphonamide derivatives
Assignee: John Wyeth and Brother Ltd
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Filing: 1985-09-30
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Granted: 1987-08-04
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Expires: 2005-09-30
Abstract
Abstract Compounds having the formula <IMAGE> (III) wherein X1 and X2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy; X3 is halogen or trifluoromethyl; one of A and E is CH and the other is CH or N and their pharmaceutically acceptable acid addition salts are useful as pharmaceuticals, in particular as anti-hypertensive agents. Novel 1-[4-(amino or nitro)benzenesulphonyl]-4-benzoylpiperazines are also disclosed as intermediate compounds.
Inventors
- 👤 John T. A. Boyle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:35
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/38; C07D215/42; C07D215/44; C07D237/00; C07D237/26; C07D237/28; C07D239/00; C07D239/70; C07D239/72; C07D239/86; C07D239/94
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A compound selected from those having the formula ##STR18## and their pharmaceutically acceptable acid addition salts, wherein X 1 and X 2 are independently selected from hydrogen, halogen, trifluoromethyl, lower alkyl and lower alkoxy; X 3 is selected from halogen and trifluoromethyl; one of A and E is CH and the other one of A and E is selected from Ch and N.
Claim 2
Dependent Claim
63 words
A compound selected from those having the formula ##STR18## and their pharmaceutically acceptable acid addition salts, wherein X 1 and X 2 are independently selected from hydrogen, halogen, trifluoromethyl, lower alkyl and lower alkoxy; X 3 is selected from halogen and trifluoromethyl; one of A and E is CH and the other one of A and E is selected from Ch and N.
Claim 3
Dependent Claim
14 words
A compound as claimed in claim 1, wherein X 3 is at the 7-position.
Claim 4
Dependent Claim
12 words
A compound as claimed in claim 1, wherein X 3 is trifluoromethyl.
Claim 5
Dependent Claim
14 words
A compound as claimed in claim 1, wherein both A and E are CH.
Claim 6
Dependent Claim
33 words
A compound as claimed in claim 1, wherein one of X 1 and X 2 is hydrogen and the other one of X 1 and X 2 is selected from halogen and trifluoromethyl.
Claim 7
Dependent Claim
20 words
A compound as claimed in claim 1, wherein the compound having formula III is 1-[4-fluorobenzoyl]-4-[4-(7-trifluoromethyl-4-quinolinylamino)benzenesulphonyl]piperazine and its pharmaceutically acceptable salts.
Claim 8
Dependent Claim
15 words
A compound as claimed in claim 1, wherein the compound having formula III is 1-[4-(7-chloro-4-quinolinylamino)benzenesulphonyl]-4-(4-fluorobenzoyl)piperazine.
Claim 9
Dependent Claim
25 words
A pharmaceutical composition for anti-hypertensive use comprising an effective quantity of a compound as claimed in claim 1 in association with a pharmaceutically acceptable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-03 | 1991-02-02 | 1991-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-03 | 1995-02-02 | 1995-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-03 | 1999-02-02 | 1999-08-04 | $7700.00 | Window Closed / Lapsed |