US4025629A
Expired / Lapsed
US
⏱️ 0.0 years remaining
P-(trifluoromethylquinolylamino)benzamides, pharmaceutical dosage forms and method of treatment
Assignee: Pharmacia and Upjohn Co
•
Filing: 1975-03-21
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Granted: 1977-05-24
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Expires: 1995-03-21
Abstract
Abstract Novel p-(trifluoromethylquinolylamino)benzamides are provided, for example, p-[(7-trifluoromethyl-4-quinolyl)-amino]-N,N-(3-methyl-3-azapentamethylene)benzamide and 1-[p-[[7-(trifluoromethyl)-4-quinolyl]amino]benzoyl]piperazine dihydrochloride. Also provided are pharmaceutical dosage unit forms for systemic administration and methods for their systemic administration. The compound, dosage unit forms and methods of systemic administration are useful in obtaining antihypertensive and anti-anxiety effects in mammals.
Inventors
- 👤 Charles E. Coverdale
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:04
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/38; C07D215/42; C07D215/44
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
1 words
p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-(3-methyl-3-azapentamethylene)benzamide.
Claim 2
Dependent Claim
1 words
p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-(3-methyl-3-azapentamethylene)benzamide.
Claim 3
Dependent Claim
2 words
1-[p-[[(7-trifluoromethyl)-4-quinolyl]-amino]-benzoyl]piperazine dihydrochloride.
Claim 4
Dependent Claim
2 words
1-[p-[[(7-trifluoromethyl)-4-quinolyl]-amino]-benzoyl]piperazine dihydrochloride.
Claim 5
Dependent Claim
51 words
A pharmaceutical dosage unit form adapted to systemic administration to obtain anti-hypertensive and anti-anxiety effects consisting essentially of an effective non-toxic amount for said effects within the range of from about 10 mg. to about 1000 mg. of p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-(3-methyl-3-azapentamethylene)benzamide in combination with pharmaceutical means which adapt the compound for systemic administration.
Claim 6
Dependent Claim
51 words
A pharmaceutical dosage unit form adapted to systemic administration to obtain anti-hypertensive and anti-anxiety effects consisting essentially of an effective non-toxic amount for said effects within the range of from about 10 mg. to about 1000 mg. of p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-(3-methyl-3-azapentamethylene)benzamide in combination with pharmaceutical means which adapt the compound for systemic administration.
Claim 7
Dependent Claim
52 words
A pharmaceutical dosage unit form adapted to systemic administration to obtain antihypertensive and anti-anxiety effects consisting essentially of an effective non-toxic amount for said effects within the range of from about 10 mg. to about 1000 mg. of 1-[p-[[(7-trifluoromethyl-4-quinolyl]amino]benzoyl]piperazine dihydrochloride in combination with pharmaceutical means which adapt the compound for systemic administration.
Claim 8
Dependent Claim
52 words
A pharmaceutical dosage unit form adapted to systemic administration to obtain antihypertensive and anti-anxiety effects consisting essentially of an effective non-toxic amount for said effects within the range of from about 10 mg. to about 1000 mg. of 1-[p-[[(7-trifluoromethyl-4-quinolyl]amino]benzoyl]piperazine dihydrochloride in combination with pharmaceutical means which adapt the compound for systemic administration.
Claim 9
Independent Claim
73 words
A method of obtaining antihypertensive and anti-anxiety effects in a mammal which consists essentially of administering systemically to the mammal a pharmaceutical dosage unit form supplying an effective non-toxic amount for antihypertensive and anti-anxiety effects of p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-(3-methyl-3-azapentamethylene)-benzamide or the pharmacologically acceptable acid addition salts thereof wherein the amount of compound administered is within the range of from about 0.1 mg. per kg. to about 15 mg. per kg. of weight of the mammal.
Claim 10
Independent Claim
73 words
A method of obtaining antihypertensive and anti-anxiety effects in a mammal which consists essentially of administering systemically to the mammal a pharmaceutical dosage unit form supplying an effective non-toxic amount for antihypertensive and anti-anxiety effects of p-[(7-trifluoromethyl-4-quinolyl)amino]-N,N-(3-methyl-3-azapentamethylene)-benzamide or the pharmacologically acceptable acid addition salts thereof wherein the amount of compound administered is within the range of from about 0.1 mg. per kg. to about 15 mg. per kg. of weight of the mammal.
Claim 11
Independent Claim
66 words
A method of obtaining antihypertensive and anti-anxiety effects in a mammal which consists essentially of administering systemically to the mammal a pharmaceutical dosage unit form supplying an effective non-toxic amount for antihypertensive and anti-anxiety effects of 1-[p-[[(7-trifluoromethyl)-4-quinolyl]amino]benzoyl]piperazine dihydrochloride wherein the amount of compound administered is within the range of from about 0.1 mg. per kg. to about 15 mg. per kg. of weight of the mammal.
Claim 12
Independent Claim
66 words
A method of obtaining antihypertensive and anti-anxiety effects in a mammal which consists essentially of administering systemically to the mammal a pharmaceutical dosage unit form supplying an effective non-toxic amount for antihypertensive and anti-anxiety effects of 1-[p-[[(7-trifluoromethyl)-4-quinolyl]amino]benzoyl]piperazine dihydrochloride wherein the amount of compound administered is within the range of from about 0.1 mg. per kg. to about 15 mg. per kg. of weight of the mammal.
References Cited (Backward Citations)
US2940974A
Cited
US3632761A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-23 | 1980-11-22 | 1981-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-23 | 1984-11-22 | 1985-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-23 | 1988-11-22 | 1989-05-24 | $7700.00 | Window Closed / Lapsed |