Patent US4684637A successfully refreshed from Google Patents.
US4684637A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of decreasing rate of heme metabolism
Assignee: Rockefeller University
•
Filing: 1985-08-19
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Granted: 1987-08-04
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Expires: 2005-08-19
Abstract
Abstract Methods for decreasing the rate of metabolism of heme in mammals by administration of tin or chromium protoporphrins IX, and compositions useful therefore.
Inventors
- 👤 Attallah Kappas
- 👤 George Drummond
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 18:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/555
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
35 words
A method of decreasing the rate of metabolism of heme in mammals in need of such treatment by administering to the mammal an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 2
Independent Claim
35 words
A method of decreasing the rate of metabolism of heme in mammals in need of such treatment by administering to the mammal an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 3
Dependent Claim
10 words
A method as in claim 1 wherein Sn-protoporphyrin is administered.
Claim 4
Dependent Claim
10 words
A method as in claim 1 wherein Cr-protoporphyrin is administered.
Claim 5
Dependent Claim
12 words
A method as in claim 2 wherein the mammal is a human.
Claim 6
Dependent Claim
12 words
A method as in claim 3 wherein the mammal is a human.
Claim 7
Independent Claim
34 words
A method of decreasing the rate of bilirubin accumulation in neonatal mammals which comprises administering to the neonate promptly after birth an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 8
Independent Claim
34 words
A method of decreasing the rate of bilirubin accumulation in neonatal mammals which comprises administering to the neonate promptly after birth an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 9
Dependent Claim
10 words
A method as in claim 6 wherein Sn-protoporphyrin is administered.
Claim 10
Dependent Claim
10 words
A method as in claim 6 wherein Cr-protoporphyrin is administered.
Claim 11
Dependent Claim
11 words
A method as in claim 7 wherein the neonate is human.
Claim 12
Dependent Claim
11 words
A method as in claim 8 wherein the neonate is human.
Claim 13
Dependent Claim
26 words
A pharmaceutical composition containing 100 to 2500 μmol of Sn-protoporphyrin or Cr-protoporphyrin per liter of non-toxic, parenteral buffered isotonic aqueous solution at pH 7 to 8.
Claim 14
Dependent Claim
26 words
A pharmaceutical composition containing 100 to 2500 μmol of Sn-protoporphyrin or Cr-protoporphyrin per liter of non-toxic, parenteral buffered isotonic aqueous solution at pH 7 to 8.
Claim 15
Dependent Claim
7 words
A composition of claim 11 containing Sn-protoporphyrin.
Claim 16
Dependent Claim
7 words
A composition of claim 11 containing Cr-protoporphyrin.
Claim 17
Dependent Claim
30 words
A pharmaceutical composition in dosage unit form containing 0.1 to 2.5 μmol of Sn-protoporphryin or Cr-protoporphyrin per milliliter of non-toxic, parenteral buffered isotonic aqueous solution at pH 7 to 8.
Claim 18
Dependent Claim
30 words
A pharmaceutical composition in dosage unit form containing 0.1 to 2.5 μmol of Sn-protoporphryin or Cr-protoporphyrin per milliliter of non-toxic, parenteral buffered isotonic aqueous solution at pH 7 to 8.
Claim 19
Dependent Claim
7 words
A composition of claim 14 containing Sn-protoporphyrin.
Claim 20
Dependent Claim
7 words
A composition of claim 14 containing Cr-protoporphyrin.
Claim 21
Dependent Claim
32 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising Sn-protporphyrin or Cr-protoporphyrin together with a pharmaceutically acceptable carrier.
Claim 22
Dependent Claim
32 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising Sn-protporphyrin or Cr-protoporphyrin together with a pharmaceutically acceptable carrier.
Claim 23
Dependent Claim
7 words
A composition of claim 17 containing Sn-protoporphyrin.
Claim 24
Dependent Claim
7 words
A composition of claim 17 containing Cr-protoporphyrin.
Claim 25
Dependent Claim
42 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising a buffered isotonic aqueous solution containing an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 26
Dependent Claim
42 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising a buffered isotonic aqueous solution containing an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 27
Dependent Claim
7 words
A composition of claim 20 containing Sn-protoporphyrin.
Claim 28
Dependent Claim
7 words
A composition of claim 20 containing Cr-protoporphyrin.
Claim 29
Dependent Claim
43 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising a buffered isotonic aqueous saline solution containing an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 30
Dependent Claim
43 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising a buffered isotonic aqueous saline solution containing an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 31
Dependent Claim
7 words
A composition of claim 23 containing Sn-protoporphyrin.
Claim 32
Dependent Claim
7 words
A composition of claim 23 containing Cr-protoporphyrin.
Claim 33
Dependent Claim
43 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising a buffered isotonic aqueous glucose solution containing an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 34
Dependent Claim
43 words
A non-toxic, parenteral pharmaceutical composition useful for decreasing the rate of metabolism of heme in mammals in need of such decreased rate comprising a buffered isotonic aqueous glucose solution containing an amount of Sn-protoporphyrin or Cr-protoporphyrin which is effective to decrease said rate.
Claim 35
Dependent Claim
7 words
A composition of claim 26 containing Sn-protoporphyrin.
Claim 36
Dependent Claim
7 words
A composition of claim 26 containing Cr-protoporphyrin.
Claim 37
Dependent Claim
22 words
A pharmaceutical composition of claims 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27 or 28 in dosage unit form.
Claim 38
Dependent Claim
6 words
A lyophilized composition of claim 17.
Claim 39
Dependent Claim
6 words
A lyophilized composition of claim 18.
Claim 40
Dependent Claim
6 words
A lyophilized composition of claim 19.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-03 | 1991-02-02 | 1991-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-03 | 1995-02-02 | 1995-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-03 | 1999-02-02 | 1999-08-04 | $7700.00 | Window Closed / Lapsed |