Magnetic resonance imaging of high velocity flows

Claim 3

The method as set forth in claim 1 further including cyclically repeating steps (a) through (g).

Claim 4

The method as set forth in claim 2 further including repeating steps (a) through (h) with an amplitude of at least one of the read and slice selection gradients altered.

Claim 5

The method as set forth in claim 2 further including repeating steps (a) through (h) with at least one of the read and slice selection gradients time shifted to reconstruct a second image.

Claim 6

The method as set forth in claim 4 wherein the first and second images each include a real and an imaginary image value for each of a plurality of corresponding pixels.

Claim 7

The method as set forth in claim 5 further including the step of determining first and second phase maps at each pixel of the first and second images from a ratio of the real and imaginary values of corresponding pixels.

Claim 8

The method as set forth in claim 6 further including the steps of determining a difference phase map by subtractively combining corresponding pixels of the first and second phase maps.

Claim 9

The method as set forth in claim 7 further including the step of adjusting at least one of the slice selection and the read time shifts to adjust a proportionality between resultant phase shifts and slice selection and read gradient direction velocity components, respectively.

Claim 12

The method as set forth in claim 9 wherein the first and second read gradients are substantially the same, such that odd derivatives of position cancel, whereby the first and second read gradients produce even-echo rephasing.

Claim 13

The method as set forth in claim 10 further including the steps of applying a pair of complimentary slice selection gradients before and after the inversion pulse to reduce sensitivity to flow in a selected slice plane.

Claim 14

The method as set forth in claim 9 further including the step of applying an inversion pulse immediately preceding the resonance excitation pulse.

Claim 15

The method as set forth in claim 9 further including repeating steps (a) through (e) with at least one of the read gradient altered to obtain a second image representation.

Claim 16

The method as set forth in claim 13 further including calculating phase maps from real and imaginary components of the first and second images and subtractively combining the phase maps.

Claim 19

The method as set forth in claim 15 further including repeating steps (a) through (e) with the second slice selection gradient altered.

Claim 20

The method as set forth in claim 15 further including the step of applying a spin inversion pulse preceding the step of applying the resonance excitation pulse.

Claim 23

A magnetic resonance apparatus for examining moving substances, the apparatus comprising: a main magnetic field control means for generating a generally uniform magnetic field through an image region; at least one coil for transmitting and receiving radio frequency signals, the coil being disposed adjacent the image region; a resonance excitation control means for selectively causing the coil to transmit a resonance excitation pulse; an inversion pulse control means for selectively causing the coil to transmit a spin inversion pulse; a receiving means for receiving a radio frequency resonance signal received by from the coil; a gradient coil means for selectively causing magnetic field gradients across the main magnetic field; a slice selection gradient means for selectively causing the gradient coil means to generate gradients for selecting a slice through the image region to be imaged; a read gradient control means for selectively causing the gradient coil means to generate a read gradient across the slice; a phase encoder means for selectively causing the gradient coil means to phase encode resonating nuclei in the selected slice; a transform means for selectively transforming the resonance signal from the receiving means into an image representation which has real and imaginary values corresponding to each of a plurality of pixels; a first memory means for storing real and imaginary portions of a first image representation which is produced when the slice selection gradient control means and the read gradient control means apply slice selection and read gradients in such a manner that an effective first moment in time in the selected slice is substantially zero; a second memory means for storing real and imaginary portions of a second image representation which is produced when at least one of the slice selection gradient control means and the read gradient control means flow encodes resonating nuclei in the selected slice by shifting at least one of the respective slice selection and read gradients; a phase determining means for determining a phase map whose intensity values vary with phase shift, the phase determining means being operatively connected with the first and second memory means for determining at least first and second phase maps from the first and second images; a first and second phase map memory means for storing the first and second phase maps, the phase map memory means being operatively connected with the velocity determining means, and; a difference means for substractively combining the first and second phase maps to correct for any stationary artifacts the difference means being operatively connected with the first and second phase map memory means.

Claim 24

A magnetic resonance apparatus for examining moving substances, the apparatus comprising: a main magnetic field control means for generating a generally uniform magnetic field through an image region; at least one coil for transmitting and receiving radio frequency signals, the coil being disposed adjacent the image region; a resonance excitation control means for selectively causing the coil to transmit a resonance excitation pulse; an inversion pulse control means for selectively causing the coil to transmit a spin inversion pulse; a receiving means for receiving a radio frequency resonance signal received by from the coil; a gradient coil means for selectively causing magnetic field gradients across the main magnetic field; a slice selection gradient means for selectively causing the gradient coil means to generate gradients for selecting a slice through the image region to be imaged; a read gradient control means for selectively causing the gradient coil means to generate a read gradient across the slice; a phase encoder means for selectively causing the gradient coil means to phase encode resonating nuclei in the selected slice; a transform means for selectively transforming the resonance signal from the receiving means into an image representation which has real and imaginary values corresponding to each of a plurality of pixels; a first memory means for storing real and imaginary portions of a first image representation which is produced when the slice selection gradient control means and the read gradient control means apply slice selection and read gradients in such a manner that an effective first moment in time in the selected slice is substantially zero; a second memory means for storing real and imaginary portions of a second image representation which is produced when at least one of the slice selection gradient control means and the read gradient control means flow encodes resonating nuclei in the selected slice by shifting at least one of the respective slice selection and read gradients; a phase determining means for determining a phase map whose intensity values vary with phase shift, the phase determining means being operatively connected with the first and second memory means for determining at least first and second phase maps from the first and second images; a first and second phase map memory means for storing the first and second phase maps, the phase map memory means being operatively connected with the velocity determining means, and; a difference means for substractively combining the first and second phase maps to correct for any stationary artifacts the difference means being operatively connected with the first and second phase map memory means.

Claim 25

A spin-echo magnetic resonance method for imaging flowing substances in a selected slice, the method comprising: (a) initially inverting a magnetization of selected dipoles of flowing and stationary substances inside and outside of the selected slice; (b) exciting magnetic resonance of the dipoles of the flowing and stationary substances in the selected slice only; (c) inverting the magnetization of the flowing and stationary substances inside and outside of the selected slices such that the dipoles of the substances outside of the selected slice during the magnetic resonance excitation are subject to two complimentary magnetization inversions and such that a spin echo is induced from the dipoles in which magnetic resonance was excited while in the selected slice; (d) applying a phase encode gradient; (e) during the spin echo, applying a read gradient and receiving magnetic resonance signals generated by the dipoles in which magnetic resonance was excited and which are inside and outside of the selected slice; (f) applying at least one additional gradient after exciting magnetic resonance and before the spin echo which additional gradient rephases the magnetization of resonating dipoles of components of the substance flowing perpendicular to the gradient relative to the magnetization of the resonating dipoles of the stationary substances and other components of the flowing substance, whereby the received magnetic resonance signals from a selected component of the flowing substance is distinguished by relative phase.

Claim 26

A spin-echo magnetic resonance method for imaging flowing substances in a selected slice, the method comprising: (a) initially inverting a magnetization of selected dipoles of flowing and stationary substances inside and outside of the selected slice; (b) exciting magnetic resonance of the dipoles of the flowing and stationary substances in the selected slice only; (c) inverting the magnetization of the flowing and stationary substances inside and outside of the selected slices such that the dipoles of the substances outside of the selected slice during the magnetic resonance excitation are subject to two complimentary magnetization inversions and such that a spin echo is induced from the dipoles in which magnetic resonance was excited while in the selected slice; (d) applying a phase encode gradient; (e) during the spin echo, applying a read gradient and receiving magnetic resonance signals generated by the dipoles in which magnetic resonance was excited and which are inside and outside of the selected slice; (f) applying at least one additional gradient after exciting magnetic resonance and before the spin echo which additional gradient rephases the magnetization of resonating dipoles of components of the substance flowing perpendicular to the gradient relative to the magnetization of the resonating dipoles of the stationary substances and other components of the flowing substance, whereby the received magnetic resonance signals from a selected component of the flowing substance is distinguished by relative phase.

Claim 27

The method as set forth in claim 20 further including correcting for phase artifacts by repeating steps (a) through (f) with the additional gradient altered to cause a different rephasing of the magnetization of the resonating dipoles of the flow component perpendicular to the gradient and combining components of the magnetic resonance signals received in sequences with the additional and altered addition gradients.

Claim 28

The method as set forth in claim 20 wherein the initial inversion of magnetization in step (a) includes applying a broadband inversion pulse.