Patent US4682603A successfully refreshed from Google Patents.
US4682603A
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Apparatus and method for recording monophasic action potentials from an in vivo heart
Assignee: Individual
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Filing: 1984-03-06
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Granted: 1987-07-28
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Expires: 2004-03-06
Abstract
Abstract The apparatus comprises a probe having a tip portion, a first electrode mounted on a terminal free end of the tip portion and a second electrode spaced along the tip portion from the first electrode for supplying a reference potential. The probe is constructed so as to hold the first electrode in contact with tissue of an in vivo beating heart with a positive pressure without causing macroscopic damage to the heart tissue while orienting the probe such that the second electrode is spaced from the heart tissue. According to the method of the present invention, a plurality of monophasic action potentials can be obtained using the apparatus of the invention. The monophasic action potentials are used to identify abnormal heart areas, such as ischemic areas.
Inventors
- 👤 Michael R. Franz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:32
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/68; A61B5/6846; A61B5/6847; A61B5/6852; A61B5/6855; A61B5/24; A61B5/25; A61B5/279; A61B5/28; A61B5/283; A61B5/29; A61B2562/00; A61B2562/02; A61B2562/0209; A61B2562/0215; A61B2562/04; A61B2562/046
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
113 words
An apparatus for measuring monophasic action potentials in an in vivo beating heart, comprising: a probe having a tip portion; a first electrode mounted on a terminal free end of said tip portion, said first electrode having a portion exposed to ambient; a second electrode spaced along said tip portion from said first electrode for supplying a reference potential signal; and means on said probe which is spring loaded for holding said first electrode in contact with tissue of a beating heart with a positive force of approximately 20-30 g without causing macroscopic damage to said heart tissue and orienting said probe such that said second electrode is spaced from said heart tissue.
Claim 2
Independent Claim
113 words
An apparatus for measuring monophasic action potentials in an in vivo beating heart, comprising: a probe having a tip portion; a first electrode mounted on a terminal free end of said tip portion, said first electrode having a portion exposed to ambient; a second electrode spaced along said tip portion from said first electrode for supplying a reference potential signal; and means on said probe which is spring loaded for holding said first electrode in contact with tissue of a beating heart with a positive force of approximately 20-30 g without causing macroscopic damage to said heart tissue and orienting said probe such that said second electrode is spaced from said heart tissue.
Claim 3
Dependent Claim
30 words
An apparatus as claimed in claim 1, further including comparator means coupled to said first and second electrode for subtracting signals received through said second electrode from said first electrode.
Claim 4
Dependent Claim
31 words
An apparatus as claimed in claim 2, wherein said comparator means is DC coupled to said first and second electrodes and has a frequency response from DC to approximately 5 kHz.
Claim 5
Dependent Claim
12 words
An apparatus as claimed in claim 1, wherein said electrodes are nonpolarizable.
Claim 6
Dependent Claim
27 words
An apparatus as claimed in claim 1, wherein said holding means comprises a flexible catheter, and said second electrode is exposed to contact fluid in the heart.
Claim 7
Dependent Claim
15 words
An apparatus as claimed in claim 5, including a guide wire disposed in said catheter.
Claim 8
Dependent Claim
26 words
An apparatus as claimed in claim 1, including means for establishing electrical continuity between said second electrode and tissue surrounding tissue contacted by said first electrode.
Claim 9
Dependent Claim
18 words
An apparatus as claimed in claim 7, wherein said holding means comprises a spring built into said probe.
Claim 10
Dependent Claim
16 words
An apparatus as claimed in claim 7, wherein said continuity path establishing means comprises saline solution.
Claim 11
Dependent Claim
23 words
An apparatus as claimed in claim 7, wherein said continuity path establishing means does not apply significant pressure to the tissue it contacts.
Claim 12
Dependent Claim
23 words
An apparatus as claimed in claim 1, wherein said first elecrode has an exposed surface on the order of approximately 1 mm across.
Claim 13
Dependent Claim
22 words
An apparatus as claimed in claim 1, wherein said electrodes are separated by a distance on the order of approximately 3-5 mm.
Claim 14
Dependent Claim
18 words
An apparatus as claimed in claim 1, wherein said exposed portion of said first electrode is generally planar.
Claim 15
Dependent Claim
25 words
An apparatus as claimed in claim 13, wherein said tip portion includes an insulative material forming a raised ridge around said first electrode exposed portion.
Claim 16
Dependent Claim
14 words
An apparatus as claimed in claim 1, wherein both said electrodes comprise silver-silver chloride.
Claim 17
Independent Claim
157 words
An apparatus for measuring monophasic action potentials in an in vivo beating heart, comprising: a probe having a tip portion; a first electrode mounted on a terminal free end of said tip portion, said first electrode having a portion exposed to ambient; a second electrode spaced along said top portion from said first electrode for supplying a reference potential signal; means on said probe for holding said first electrode in contact with tissue of a beating heart with a positive pressure without causing macroscopic damage to said heart tissue and orienting said probe such that said second electrode is spaced from said heart tissue, said holding means comprising a spring built into said probe; and means for establishing electrial continuity between said second electrode and tissue surrounding tissue contacted by said first electrode, said continuity establishing means comprising saline solution and a foam material on said tip portion, said saline solution being received in said foam material.
Claim 18
Independent Claim
157 words
An apparatus for measuring monophasic action potentials in an in vivo beating heart, comprising: a probe having a tip portion; a first electrode mounted on a terminal free end of said tip portion, said first electrode having a portion exposed to ambient; a second electrode spaced along said top portion from said first electrode for supplying a reference potential signal; means on said probe for holding said first electrode in contact with tissue of a beating heart with a positive pressure without causing macroscopic damage to said heart tissue and orienting said probe such that said second electrode is spaced from said heart tissue, said holding means comprising a spring built into said probe; and means for establishing electrial continuity between said second electrode and tissue surrounding tissue contacted by said first electrode, said continuity establishing means comprising saline solution and a foam material on said tip portion, said saline solution being received in said foam material.
Claim 19
Independent Claim
108 words
A method of measuring monophasic action potentials in an vivo heart using a probe having a spring loaded portion and having a tip portion with a first electrode at an extremis of said tip portion, and a second electrode spaced along said probe from said tip portion, comprising: positioning said probe such that said first electrode is held against heart tissue and said spring loaded portion maintains a positive force on the order of 20-30 grams over the exposed area of said first electrode and said second electrode is spaced from said heart tissue; and comparing signals from said first electrode to reference signals from said second electrode.
Claim 20
Independent Claim
108 words
A method of measuring monophasic action potentials in an vivo heart using a probe having a spring loaded portion and having a tip portion with a first electrode at an extremis of said tip portion, and a second electrode spaced along said probe from said tip portion, comprising: positioning said probe such that said first electrode is held against heart tissue and said spring loaded portion maintains a positive force on the order of 20-30 grams over the exposed area of said first electrode and said second electrode is spaced from said heart tissue; and comparing signals from said first electrode to reference signals from said second electrode.
Claim 21
Dependent Claim
20 words
A method as claimed in claim 17, including the preliminary step of short-circuiting said electrodes to balance half cell potentials.
Claim 22
Dependent Claim
19 words
A method as claimed in claim 18, wherein said electrodes are short-circuited by immersing said electrodes in saline solution.
Claim 23
Dependent Claim
22 words
A method as claimed in claim 17, wherein said probe includes a flexible catheter and said positioning step includes percutaneous catheter insertion.
Claim 24
Independent Claim
129 words
A method of detecting an abnormal heart condition using a probe having a spring loaded portion and having a tip electrode comprising: measuring monophasic action potentials of a plurality of sites on the surface of said heart by pressing said tip electrode against said heart surface at each of said sites using said spring loaded portion to maintain a positive pressure on the order of 20 to 30 grams, comparing a signal received by said tip electrode against a reference potential and recording a monophasic action potential; and identifying abnormal heart areas by comparing recorded monophasic action potentials against one another and identifying monophasic action potentials which have a reduced amplitude relative to other monophasic action potentials, said reduced amplitude monophasic action potentials being associated with abnormal heart areas.
Claim 25
Independent Claim
129 words
A method of detecting an abnormal heart condition using a probe having a spring loaded portion and having a tip electrode comprising: measuring monophasic action potentials of a plurality of sites on the surface of said heart by pressing said tip electrode against said heart surface at each of said sites using said spring loaded portion to maintain a positive pressure on the order of 20 to 30 grams, comparing a signal received by said tip electrode against a reference potential and recording a monophasic action potential; and identifying abnormal heart areas by comparing recorded monophasic action potentials against one another and identifying monophasic action potentials which have a reduced amplitude relative to other monophasic action potentials, said reduced amplitude monophasic action potentials being associated with abnormal heart areas.
Claim 26
Dependent Claim
40 words
A method as claimed in claim 21 including the steps of forming a first time derivative of each recorded monophasic action potential and identifying abnormal heart areas as areas associated with monophasic action potentials having a reduced maximum first derivative.
Claim 27
Dependent Claim
33 words
A method as claimed in claim 21, including measuring said reference potential using an electrode in electrical continuity through a volume conductor with tissue adjacent tissue against which said tip electrode is pressed.
Claim 28
Dependent Claim
28 words
A method as claimed in claim 23, wherein said volume conductor is formed of body fluids and said tip electrode is pressed against the surface of the endocardium.
Claim 29
Dependent Claim
25 words
A method as claimed in claim 23, wherein said volume conductor is formed of saline solution and said tip electrode is pressed against the epicardium.
References Cited (Backward Citations)
SU730346A1
Cited
US4172451A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-27 | 1991-01-26 | 1991-07-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-27 | 1995-01-26 | 1995-07-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-27 | 1999-01-26 | 1999-07-28 | $7700.00 | Window Closed / Lapsed |