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US4681890A
Expired / Lapsed
US
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3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
Assignee: Kuraray Co Ltd
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Filing: 1985-10-23
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Granted: 1987-07-21
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Expires: 2005-10-23
Abstract
Abstract Novel 3,4-dihydrobenzopyran compounds of the formula: <IMAGE> (I) wherein R1, R2 and R3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0, 1 or 2, and n is an integer of 0 or 1, which is useful for prophylaxis and treatment of hyperlipemia and the compounds wherein R1 and R3 being nicotinoyl group and n is 0 being also effective for prophylaxis and treatment of hepatic diseases, and pharmaceutical composition containing said compounds as an active ingredient.
Inventors
- 👤 Koichi Kanehira
- 👤 Manzo Shiono
- 👤 Yoshiji Fujita
- 👤 Takashi Nishida
- 👤 Johji Yamahara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:12
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/12; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/455; C07D405/14
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
49 words
A 3,4-dihydrobenzopyran compound of the formula: ##STR14## wherein R 1 , R 2 and R 3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0, 1 or 2, and n is an integer of 0 or 1.
Claim 2
Dependent Claim
49 words
A 3,4-dihydrobenzopyran compound of the formula: ##STR14## wherein R 1 , R 2 and R 3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0, 1 or 2, and n is an integer of 0 or 1.
Claim 3
Dependent Claim
10 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-nicotinoyloxyethyl-2,5,7,8-tetramethyl-2H-benzopyran-6-ol.
Claim 4
Dependent Claim
11 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-nicotinoyloxyethyl-2,5,7,8-tetramethyl-2H-benzopyran-6-yl nicotinate.
Claim 5
Dependent Claim
11 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-hydroxyethyl-2,5,7,8-tetramethyl-2H-benzopyran-6-yl nicotinate.
Claim 6
Dependent Claim
10 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-nicotinoyloxymethyl-2,5,7,8-tetramethyl-2H-benzopyran-6-ol.
Claim 7
Dependent Claim
11 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-nicotinoyloxymethyl-2,5,7,8-tetramethyl-2H-benzopyran-6-yl nicotinate.
Claim 8
Dependent Claim
11 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-nicotinoyloxypropyl-2,5,7,8-tetramethyl-2H-benzopyran-6-yl nicotinate.
Claim 9
Dependent Claim
11 words
The compound as claimed in claim 1, which is 3,4-dihydro-2-[2,3-di(nicotinoyloxy)propyl]-2,5,7,8-tetramethyl-2H-benzopyran-6-yl nicotinate.
Claim 10
Dependent Claim
81 words
A pharmaceutical composition for the prophylaxis and treatment of hyperlipemia which comprises as an active ingredient a prophylactically or therapeutically effective amount of a 3,4-dihydrobenzopyran compound of the formula: ##STR15## wherein R 1 , R 2 and R 3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0, 1 or 2, and n is an integer of 0 or 1, in admixture with a pharmaceutically acceptable carrier or diluent.
Claim 11
Dependent Claim
81 words
A pharmaceutical composition for the prophylaxis and treatment of hyperlipemia which comprises as an active ingredient a prophylactically or therapeutically effective amount of a 3,4-dihydrobenzopyran compound of the formula: ##STR15## wherein R 1 , R 2 and R 3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0, 1 or 2, and n is an integer of 0 or 1, in admixture with a pharmaceutically acceptable carrier or diluent.
Claim 12
Dependent Claim
50 words
A pharmaceutical composition for the prophylaxis and treatment of hepatic diseases, which comprises as an active ingredient a prophylactically or therapeutically effective amount of a 3,4-dihydrobenzopyran compound of the formula: ##STR16## wherein m is an integer of 0, 1 or 2, in admixture with a pharmaceutically acceptable carrier or diluent.
Claim 13
Dependent Claim
50 words
A pharmaceutical composition for the prophylaxis and treatment of hepatic diseases, which comprises as an active ingredient a prophylactically or therapeutically effective amount of a 3,4-dihydrobenzopyran compound of the formula: ##STR16## wherein m is an integer of 0, 1 or 2, in admixture with a pharmaceutically acceptable carrier or diluent.
Claim 14
Dependent Claim
35 words
A method for the prophylaxis or treatment of hyperlipemia which comprises administering to an animal susceptible to or suffering from hyperlipemia a prophylactically or therapeutically effective amount of 3,4-dihydrobenzopyran compound as defined in claim 1.
Claim 15
Independent Claim
49 words
A method for the prophylaxis or treatment of hepatic diseases, which comprises administering to a human or other animal susceptible to or suffering from hepatic disease a prophylactically or therapeutically effective amount of a 3,4-dihydrobenzopyran of the formula: ##STR17## wherein m is an integer of 0, 1 or 2.
Claim 16
Independent Claim
49 words
A method for the prophylaxis or treatment of hepatic diseases, which comprises administering to a human or other animal susceptible to or suffering from hepatic disease a prophylactically or therapeutically effective amount of a 3,4-dihydrobenzopyran of the formula: ##STR17## wherein m is an integer of 0, 1 or 2.
References Cited (Backward Citations)
JPS5594382A
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JPS5618578A
Cited
JPS5618579A
Cited
JPS56145283A
Cited
JPS57146768A
Cited
JPS57158776A
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JPS585168A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-20 | 1991-01-19 | 1991-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-20 | 1995-01-19 | 1995-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-20 | 1999-01-19 | 1999-07-21 | $7700.00 | Window Closed / Lapsed |