Capsules containing the active principle of an allergen, and process for their preparation

Claim 1

A telescoping two piece hard gelatine capsule perforated to emit powder through the holes, to be administered through insertion in an inhaler, inhaler tube or nasal spray, containing 40 mgs. per capsule of a finely subdivided freeze dry, anhydrous powder mixture whose particles are 90% smaller than 10 microns and the remainder 10% smaller than 20 microns of the active constituent of an allergen, which is a member selected from the group consisting of Dermatophagoides pteronyssinus, Dermatophagoides farinae, Ambrosia elatior, Agrostis maritima, Agrostis stolonifera, Poa pratensis, Dactylis glomerata, Holcus lamatus, Phleum pratense, Phalaris Canariensis, Lolium perenne, Lolium multiflorum, Festuca pratensis, Festuca ovina, Cynodon dactylon and Agarostis alba., said active constituent being uniformly dispersed into at least one lactose glucose or saccharose excipient having no brochoconstrictive or irritating action on the nasal mucous membrane in a ratio of excipient to allergen between 1:1 and 50,000:1.

Claim 3

A method of administration of an allergen to an individual who suffers from an allergy, which consists of administering to said individual a powder by emission through the holes of a perforated telescoping two piece hard gelatine capsule inserted in an inhaler or inhaler tube or nasal spray, said capsule containing 40 mgs. of a freeze dry, anhydrous powder which consists of a mixture whose particles are 90% smaller than 10 microns and the remainder 10% smaller than 20 microns of the active constituent of an allergen which is a member selected from the group consisting of Dermatophagoides pteronyssinus, Dermatophagoides farinae, Ambrosia elatior, Agrostis maritima, Agrostis stolonifera, Poa pratensis, Dactylis glomerata, Holcus lamatus, Phleum pratense, Phalaris canariensis, Lolium perenne, Lolium multiflorum, Festuca pratensis, Festuca ovina, Cynodon dactylon and Agrostis alba., said active constituent being uniformly dispensed in at least one lactose, glucose or saccharose excipient having no bronchoconstriction and irritation actions on the nasal mucous membrane, in a ratio of excipient to allergen between 1:1 and 50,000:1, said dry powder having a particle size lower than 50 microns.

Claim 4

A method of administration of an allergen to an individual who suffers from an allergy, which consists of administering to said individual a powder by emission through the holes of a perforated telescoping two piece hard gelatine capsule inserted in an inhaler or inhaler tube or nasal spray, said capsule containing 40 mgs. of a freeze dry, anhydrous powder which consists of a mixture whose particles are 90% smaller than 10 microns and the remainder 10% smaller than 20 microns of the active constituent of an allergen which is a member selected from the group consisting of Dermatophagoides pteronyssinus, Dermatophagoides farinae, Ambrosia elatior, Agrostis maritima, Agrostis stolonifera, Poa pratensis, Dactylis glomerata, Holcus lamatus, Phleum pratense, Phalaris canariensis, Lolium perenne, Lolium multiflorum, Festuca pratensis, Festuca ovina, Cynodon dactylon and Agrostis alba., said active constituent being uniformly dispensed in at least one lactose, glucose or saccharose excipient having no bronchoconstriction and irritation actions on the nasal mucous membrane, in a ratio of excipient to allergen between 1:1 and 50,000:1, said dry powder having a particle size lower than 50 microns.