US4680308A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable soluble 1,2-diaminocyclohexane platinum complexes
Assignee: Andrulis Pharmaceuticals Corp
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Filing: 1985-12-26
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Granted: 1987-07-14
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Expires: 2005-12-26
Abstract
Abstract Platinum complexes of the formula <IMAGE> wherein Z is -CO- or a single bond and R is -COOH or -SO3H, and the pharmaceutically acceptable salts thereof with bases, are stable readily water-soluble pharmaceutically active compounds having antitumor, anti-inflammatory and trypanocidal activities.
Inventors
- 👤 Paul Schwartz
- 👤 Devinder S. Gill
- 👤 Kenneth J. McGrath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 08:25
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
29 words
A platinum complex of the formula ##STR5## wherein Z is --CO-- or a single bond and R is --COOH or --SO 3 H, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
29 words
A platinum complex of the formula ##STR5## wherein Z is --CO-- or a single bond and R is --COOH or --SO 3 H, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
10 words
A complex according to claim 1, wherein Pt is Pt(II).
Claim 4
Dependent Claim
15 words
A complex according to claim 1, wherein the cyclohexane ring is in the trans configuration.
Claim 5
Dependent Claim
12 words
A complex according to claim 1, wherein Z is a single bond.
Claim 6
Dependent Claim
10 words
A complex according to claim 1, wherein Z is --CO.
Claim 7
Dependent Claim
10 words
A complex according to claim 1, wherein R is --COOH.
Claim 8
Dependent Claim
12 words
A complex according to claim 1, wherein R is --SO 3 H.
Claim 9
Dependent Claim
8 words
4-Carboxycatecholato(trans-1,2-diaminocyclohexane) -platinum(II), a complex according to claim 1.
Claim 10
Dependent Claim
8 words
5-Sulfosalicylato(trans-1,2-diaminocyclohexane) -platinum(II), a complex according to claim 1.
Claim 11
Dependent Claim
8 words
5-Carboxysalicylato(trans-1,2-diaminocyclohexane) -platinum(II), a complex according to claim 1.
Claim 12
Dependent Claim
8 words
4-Sulfocatecholato(trans-1,2-diaminocyclohexane) -platinum(II), a complex according to claim 1.
Claim 13
Dependent Claim
40 words
A pharmaceutical composition comprising a concentration effective to achieve an antitumor effect against a tumor respsonsive to platinum complex antitumor therapy, of a complex according to claim 1 in sterile admixture with a pharmaceutically acceptable carrier adapted for systemic admistration.
Claim 14
Dependent Claim
10 words
An admixture according to claim 12, adapted for intravenous administration.
Claim 15
Dependent Claim
11 words
An admixture according to claim 12, wherein the vehicle is aqueous.
Claim 16
Dependent Claim
12 words
An admixture according to claim 12, wherein the complex is 5-sulfosalicylato(1,2-diaminocyclohexane)platinum (II).
Claim 17
Dependent Claim
12 words
An admixture according to claim 12, wherein the complex is 5-carboxysalicylato(1,2-diaminocyclohexane)platinum (II).
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-13 | 1991-01-12 | 1991-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-13 | 1995-01-12 | 1995-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-13 | 1999-01-12 | 1999-07-14 | $7700.00 | Window Closed / Lapsed |