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US4677110A
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N-benzoyl-N'-pyrimidinyloxyphenyl urea compounds, and antitumorous compositions containing them
Assignee: Ishihara Sangyo Kaisha Ltd
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Filing: 1985-06-04
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Granted: 1987-06-30
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Expires: 2005-06-04
Abstract
Abstract N-benzoyl-N'-pyrimidinyloxyphenyl urea compounds having the formula: ##STR1## wherein X represents a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group and Z represents a hydrogen atom or a halogen atom, are useful as active ingredients of antitumorous compositions.
Inventors
- 👤 Takahiro Haga
- 👤 Nobutoshi Yamada
- 👤 Hideo Sugi
- 👤 Toru Koyanagi
- 👤 Hiroshi Okada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 17:05
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/34; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
28 words
An N-benzoyl-N'-pyrimidinyloxyphenyl urea compound having the formula: ##STR8## wherein X is a halogen atom, or a nitro group, and Z is a hydrogen atom or a halogen atom.
Claim 2
Dependent Claim
28 words
An N-benzoyl-N'-pyrimidinyloxyphenyl urea compound having the formula: ##STR8## wherein X is a halogen atom, or a nitro group, and Z is a hydrogen atom or a halogen atom.
Claim 3
Dependent Claim
18 words
The compound according to claim 1, wherein X is a nitro group and Z is a halogen atom.
Claim 4
Dependent Claim
9 words
The compound according to claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-bromo-2-pyrimidinyloxy)-3-trifluoromethylphenyl]urea.
Claim 5
Dependent Claim
9 words
The compound according to claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-chloro-2-pyrimidinyloxy)-3-trifluoromethylphenyl]urea.
Claim 6
Dependent Claim
9 words
The compound according to claim 1, which is N-(2-nitrobenzoyl)-N'-[4-(5-iodo-2-pyrimidinyloxy)-3-trifluoromethylphenyl]urea.
Claim 7
Dependent Claim
29 words
A composition for treating mammalian leukemia comprising an N-benzoyl-N'-pyrimidinyloxyphenyl urea compound as defined in claim 1 in an amount sufficient to exhibit antileukemia activity and a pharmacologically acceptable adjuvant.
Claim 8
Dependent Claim
29 words
A method for treating mammalian leukemia which comprises administering to a mammal an N-benzoyl-N'-pyrimidinyloxyphenyl urea compound as defined in claim 1 in an amount sufficient to exhibit antileukemia activity.
Claim 9
Dependent Claim
28 words
An intermediate compound having the formula: ##STR9## wherein R 2 is an amino group or an isocyanate group, and Z is a hydrogen atom or a halogen atom.
Claim 10
Dependent Claim
28 words
An intermediate compound having the formula: ##STR9## wherein R 2 is an amino group or an isocyanate group, and Z is a hydrogen atom or a halogen atom.
Claim 11
Dependent Claim
23 words
The compound according to claim 8, wherein R 2 is an amino group, and Z is a hydrogen atom or a halogen atom.
Claim 12
Dependent Claim
19 words
The compound according to claim 8, wherein R 2 is an amino group, and Z is a halogen atom.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-29 | 1990-12-29 | 1991-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-29 | 1994-12-29 | 1995-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-29 | 1998-12-29 | 1999-06-30 | $7700.00 | Window Closed / Lapsed |