Patent US4675161A successfully refreshed from Google Patents.
US4675161A
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Indicator for detection of thermal history
Assignee: Sakata Inx Corp
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Filing: 1983-12-29
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Granted: 1987-06-23
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Expires: 2003-12-29
Abstract
Abstract An indicator comprising azo dye(s), epoxy compound(s) and a separating membrane can be utilized for detection of the completion of thermal sterilization treatment in the medical field and also for thermal inspection in such various fields as testing, instrumentation and the like. The indicator can be used also for detection of the completion of alkylene oxide gas sterilization treatment by ethylene oxide gas or the like.
Inventors
- 👤 Harumi Hashimoto
- 👤 Isamu Hirano
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:05
CPC Classifications
G; G01; G01N; G01N31/00; G01N31/22; C; C12; C12Q; C12Q1/00; C12Q1/02; C12Q1/22; Y; Y10; Y10S; Y10S428/00; Y10S428/913; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249994; Y10T428/249995; Y10T428/249996; Y10T428/249997; Y10T436/00; Y10T436/14; Y10T436/142222; Y10T436/20
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
211 words
An indicator for detection of thermal history which comprises: (a) at least one azo dye selected from the group consisting of ##STR18## wherein each R 1 is a hydrogen or an undissociative substituent selected from the group consisting of halogen atoms, lower alkyl groups, lower alkoxy groups, alkoxy alkyl groups, aromatic groups, nitro group and acylamino group, and Y is a group of the formula ##STR19## wherein R 2 has the same definition as R 1 ; (b) at least one epoxy compound selected from the group consisting of polyethylene oxides; polypropylene oxides; polybutylene oxides; polyepichlorohydrins; styrene oxide; glycidyl phenyl ether; diepoxy or triepoxy compounds obtained by the reaction between a polyhydric alcohol and epichlorohydrin; epoxy compounds of the type of a glycidyl ester of an acid; and epoxy resins of the glycidyl ester type, bisphenol A type, bisphenol F type, phenolic novolak type and polyalcohol ether type; and (c) a separating membrane having a melting or softening point of 50° to 300° C., composed of a heat-melting or heat-softening material which does not react with said epoxy compound (b), and having a thickness of 0.5 to 200μ; said element (a) and said element (b) are adjacent through said separating member (c) thereby providing an indicator for detection of thermal history.
Claim 2
Dependent Claim
211 words
An indicator for detection of thermal history which comprises: (a) at least one azo dye selected from the group consisting of ##STR18## wherein each R 1 is a hydrogen or an undissociative substituent selected from the group consisting of halogen atoms, lower alkyl groups, lower alkoxy groups, alkoxy alkyl groups, aromatic groups, nitro group and acylamino group, and Y is a group of the formula ##STR19## wherein R 2 has the same definition as R 1 ; (b) at least one epoxy compound selected from the group consisting of polyethylene oxides; polypropylene oxides; polybutylene oxides; polyepichlorohydrins; styrene oxide; glycidyl phenyl ether; diepoxy or triepoxy compounds obtained by the reaction between a polyhydric alcohol and epichlorohydrin; epoxy compounds of the type of a glycidyl ester of an acid; and epoxy resins of the glycidyl ester type, bisphenol A type, bisphenol F type, phenolic novolak type and polyalcohol ether type; and (c) a separating membrane having a melting or softening point of 50° to 300° C., composed of a heat-melting or heat-softening material which does not react with said epoxy compound (b), and having a thickness of 0.5 to 200μ; said element (a) and said element (b) are adjacent through said separating member (c) thereby providing an indicator for detection of thermal history.
Claim 3
Dependent Claim
46 words
The indicator according to claim 1, wherein there are coated, on a substrate, the element (a) of at least one azo dye, the element (c) of a separating membrane and the element (b) of at least one epoxy compound in that order and in three layers.
Claim 4
Dependent Claim
20 words
The indicator according to claim 1, wherein the azo dye is a member selected from the group consisting of ##STR20##
Claim 5
Dependent Claim
83 words
The indicator according to claim 1, wherein the epoxy compound is a member selected from the group consisting of; diepoxy or triepoxy compounds obtained by the reaction between a polyhydric alcohol selected from the group consisting of glycol, glycerine and bisphenol A and epichlorohydrin; epoxy compounds of the type of a glycidyl ester of an acid selected from the group consisting of acrylic acid, methacrylic acid, acetic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, adipic acid and maleic acid.
Claim 6
Dependent Claim
86 words
The indicator according to claim 1, wherein the element of the separating membrane is a member selected from the group consisting of vinyl acetate resins, vinyl chloride resins, ethylene-vinyl acetate copolymer resins, vinyl chloride-vinyl acetate copolymer resins, styrene resins, acrylic resins, polyamide resins, alkyd resins, petroleum resins, coumarone-indene resins, cyclized rubbers, urethane resins, styrene-acryl copolymer resins, styrene-maleic acid copolymer resins, maleic acid resins, rosin modified maleic acid resins, polyvinyl alcohols, polyvinyl acetals, zein, casein, CMC, shellac, acrylic emulsions, styrene-acryl emulsions, styrene-shellac emulsions and vinyl acetate emulsions.
Claim 7
Dependent Claim
10 words
The indicator according to claim 1 attached to a label.
Claim 8
Dependent Claim
10 words
The indicator according to claim 1 attached to a tape.
Claim 9
Dependent Claim
11 words
The indicator according to claim 1 attached to a test piece.
Claim 10
Dependent Claim
10 words
The indicator according to claim 1 attached to a bag.
Claim 11
Dependent Claim
26 words
The indicator according to claim 1, wherein an acid catalyst for controlling the reaction between said azo dye and said epoxy compound is further present therein.
Claim 12
Dependent Claim
32 words
The indicator according to claim 10, wherein the acid catalyst is at least one member selected from the group consisting of phosphoric acid, p-toluenesulfonic acid, citric acid, maleic acid and malonic acid.
Claim 13
Dependent Claim
34 words
The indicator according to claim 1, wherein said undissociative substituent is selected from the group consisting of methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, butoxy, ethylol, methylol, methoxy methyl, phenyl, phenoxy, benzyl and nitro.
Claim 14
Dependent Claim
86 words
The indicator according to claim 12, wherein the element of the separating membrane is a member selected from the group consisting of vinyl acetate resins, vinyl chloride resins, ethylene-vinyl acetate copolymer resins, vinyl chloride-vinyl acetate copolymer resins, styrene resins, acrylic resins, polyamide resins, alkyd resins, petroleum resins, coumarone-indene resins, cyclized rubbers, urethane resins, styrene-acryl copolymer resins, styrene-maleic acid copolymer resins, maleic acid resins, rosin modified maleic acid resins, polyvinyl alcohols, polyvinyl acetals, zein, casein, CMC, shellac, acrylic emulsions, styrene-acryl emulsions, styrene-shellac emulsions and vinyl acetate emulsions.
Claim 15
Dependent Claim
26 words
The indicator according to claim 13, wherein an acid catalyst for controlling the reaction between an azo dye and an epoxy compound is further present therein.
Claim 16
Dependent Claim
32 words
The indicator according to claim 14, wherein the acid catalyst is at least one member selected from the group consisting of phosphoric acid, p-toluenesulfonic acid, citric acid, maleic acid and malonic acid.
Claim 17
Dependent Claim
30 words
The indicator according to claim 15, wherein the element (b) of at least one epoxy compound is contained in microcapsules whose shell is the element (c) of a separating membrane.
Claim 18
Dependent Claim
30 words
The indicator according to claim 12, wherein the element (b) of at least one epoxy compound is contained in microcapsules whose shell is the element (c) of a separating membrane.
Claim 19
Dependent Claim
34 words
The indicator according to claim 17, wherein a uniform mixture of the element (a) of at least one azo dye and the microcapsules is coated on a substrate in the form of a layer.
Claim 20
Dependent Claim
40 words
The indicator according to claim 17, wherein the element (a) of at least one azo dye is coated on a substrate in the form of a layer and thereon the microcapsules are coated also in the form of a layer.
Claim 21
Dependent Claim
32 words
The indicator according to claim 13, wherein the acid catalyst is at least one member selected from the group consisting of phosphoric acid, p-toluenesulfonic acid, citric acid, maleic acid and malonic acid.
Claim 22
Dependent Claim
30 words
The indicator according to claim 20, wherein the element (b) of at least one epoxy compound is contained in microcapsules whose shell is the element (c) of a separating membrane.
Claim 23
Dependent Claim
26 words
The indicator according to claim 12, wherein an acid catalyst for controlling the reaction between an azo dye and an epoxy compound is further present therein.
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