US4673634A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Purified antigen from non-A, non-B hepatitis causing factor
Assignee: HEALTH AND HUMAN SERVICES United States, Secretary of, Department of
•
Filing: 1985-03-08
•
Granted: 1987-06-16
•
Expires: 2005-03-08
Abstract
Abstract The present invention discloses an isolated and purified antigen specific to non-A, non-B hepatitis (NANBH) causing agent. The utility of the antigen as a diagnostic serologic marker and as a screening device for detecting the carrier or source of non-A, non-B hepatitis or infective factor thereof, particularly in a blood bank or plasmapheresis setting and preventing transmission of NANBH by isolating the source is described. Use of the antigen as vaccine to induce protective antibodies capable of neutralizing NANBH infectivity is also disclosed. A kit for detecting the presence or identifying the carriers or sources of non-A, non-B hepatitis or causative agent thereof is also disclosed.
Inventors
- 👤 Belinda Seto
- 👤 Robert J. Gerety
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:25
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/29; C; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24234; Y; Y10; Y10S; Y10S435/00; Y10S435/81; Y10S435/961; Y10S436/00; Y10S436/82; Y10S530/00; Y10S530/82; Y10S530/826
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
81 words
An isolated, purified non-A, non-B hepatitis (NANBH) associated antigen having the following properties: (a) molecular weight of the monomer on sodium dodecyl sulphate polyacrylamide gel being about 77,000; (b) the monomer being reactive with rhesus monkey immune serum; (c) being a glycoprotein containing about 2% carbohydrate comprising substantially mannose and about equal ratio of fucose and galactose; (d) having an aromatic amino acid composition comprising molecular ratios of phenylalanine, tyrosine and tryptophan of about 3:3:1 respectively; and (e) being an immunogen.
Claim 2
Dependent Claim
81 words
An isolated, purified non-A, non-B hepatitis (NANBH) associated antigen having the following properties: (a) molecular weight of the monomer on sodium dodecyl sulphate polyacrylamide gel being about 77,000; (b) the monomer being reactive with rhesus monkey immune serum; (c) being a glycoprotein containing about 2% carbohydrate comprising substantially mannose and about equal ratio of fucose and galactose; (d) having an aromatic amino acid composition comprising molecular ratios of phenylalanine, tyrosine and tryptophan of about 3:3:1 respectively; and (e) being an immunogen.
Claim 3
Dependent Claim
8 words
Antibodies specifically reactive to antigen of claim 1.
Claim 4
Dependent Claim
18 words
A pharmaceutical composition comprising immunogenic amount of isolated, purified antigen of claim 1 and a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
27 words
A kit for screening or detecting a carrier, source or causative factor of non-A, non-B hepatitis comprising a container containing an isolated, purified antigen of claim 1.
Claim 6
Dependent Claim
16 words
The kit of claim 4 further comprising a container containing antibodies specifically reactive to said antigen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-15 | 1990-12-15 | 1991-06-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-15 | 1994-12-15 | 1995-06-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-15 | 1998-12-15 | 1999-06-16 | $7700.00 | Window Closed / Lapsed |