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US4672319A
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Multiple pulse excitation in NMR imaging
Assignee: Leland Stanford Junior University
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Filing: 1984-09-19
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Granted: 1987-06-09
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Expires: 2004-09-19
Abstract
Abstract Improved nuclei excitation for NMR applications is provided by employing a sequence of RF pulses for exciting the nuclei. Non-linearities in pulse excitation are compensated by applying at least one additional RF pulse thereby improving slice definition and/or phase characteristics. In one application, one or more initial RF pulses establish an intermediate state for the nuclei from which the nuclei can be tilted to a final desired magnetic moment state by the application of a single RF pulse. The order of applying the magnetic pulses can be reversed when the flip/angle is 180 degrees.
Inventors
- 👤 Dwight G. Nishimura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:42
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/483; G01R33/4833
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
191 words
For use in NMR imaging wherein a static magnetic field and a gradient magnetic field are imposed on nuclei along a first axis and a composite RF magnetic field at a Larmor frequency is imposed on said nuclei along a first transverse axis for exciting said nuclei and flipping the magnetic moments of said nuclei from the first axis by a desired angle, a method of exciting said nuclei with said composite RF magnetic field comprising the steps of imposing at least a first RF magnetic field at said Larmor frequency on said nuclei and thereby establishing an intermediate state of magnetic moment distribution, said first RF magnetic field functioning as a corrective field and being defined by Bloch equation using the configuration of a second RF magnetic field, the applied static and gradient field, and the desired magnetic moment distribution of the nuclei to establish a residual magnetic moment distribution for the nuclei, and Fourier analysis of said residual magnetic moment distribution, and imposing said second RF magnetic field at said Larmor frequency along said first transverse axis for flipping said nuclei from said intermediate state to a desired angle.
Claim 2
Dependent Claim
191 words
For use in NMR imaging wherein a static magnetic field and a gradient magnetic field are imposed on nuclei along a first axis and a composite RF magnetic field at a Larmor frequency is imposed on said nuclei along a first transverse axis for exciting said nuclei and flipping the magnetic moments of said nuclei from the first axis by a desired angle, a method of exciting said nuclei with said composite RF magnetic field comprising the steps of imposing at least a first RF magnetic field at said Larmor frequency on said nuclei and thereby establishing an intermediate state of magnetic moment distribution, said first RF magnetic field functioning as a corrective field and being defined by Bloch equation using the configuration of a second RF magnetic field, the applied static and gradient field, and the desired magnetic moment distribution of the nuclei to establish a residual magnetic moment distribution for the nuclei, and Fourier analysis of said residual magnetic moment distribution, and imposing said second RF magnetic field at said Larmor frequency along said first transverse axis for flipping said nuclei from said intermediate state to a desired angle.
Claim 3
Dependent Claim
24 words
The method as defined by claim 1 wherein said Fourier analysis considers gradient polarity of the gradient magnetic field during the corrective field application.
Claim 4
Dependent Claim
41 words
The method as defined by claim 1 wherein said first RF magnetic field is imposed in the presence of a first gradient magnetic field and said second RF magnetic field is imposed in the presence of a second gradient magnetic field.
Claim 5
Dependent Claim
17 words
The method as defined by claim 3 wherein said first and second gradients have the same polarity.
Claim 6
Dependent Claim
16 words
The method as defined by claim 3 wherein said first and second gradients have opposite polarity.
Claim 7
Dependent Claim
185 words
For use in NMR imaging wherein a static magnetic field and a gradient magnetic field are imposed on nuclei along a first axis and an RF magnetic field at a Larmor frequency is imposed on said nuclei along a first transverse axis for exciting a selected region of said nuclei and flipping the magnetic moments of said nuclei from the first axis by a desired angle, a method of exciting said nuclei with the RF magnetic field comprising the steps of applying first and second pulsed magnetic excitations at said Larmor frequency, said first pulsed magnetic excitation flipping said nuclei and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution, said second pulsed magnetic excitation being defined by Bloch equation using the configuration of said first pulsed magnetic excitation and said RF magnetic field, said static magnetic field and said gradient magnetic field, and said desired magnetic moment distribution of said nuclei to establish a residual magnetic moment distribution, and Fourier analysis of said residual magnetic moment distribution.
Claim 8
Dependent Claim
185 words
For use in NMR imaging wherein a static magnetic field and a gradient magnetic field are imposed on nuclei along a first axis and an RF magnetic field at a Larmor frequency is imposed on said nuclei along a first transverse axis for exciting a selected region of said nuclei and flipping the magnetic moments of said nuclei from the first axis by a desired angle, a method of exciting said nuclei with the RF magnetic field comprising the steps of applying first and second pulsed magnetic excitations at said Larmor frequency, said first pulsed magnetic excitation flipping said nuclei and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution, said second pulsed magnetic excitation being defined by Bloch equation using the configuration of said first pulsed magnetic excitation and said RF magnetic field, said static magnetic field and said gradient magnetic field, and said desired magnetic moment distribution of said nuclei to establish a residual magnetic moment distribution, and Fourier analysis of said residual magnetic moment distribution.
Claim 9
Dependent Claim
159 words
Apparatus for use in NMR imaging comprising means for applying to nuclei a static magnetic field along a first axis, means for applying to said nuclei a gradient magnetic field along said first axis, means for applying to said nuclei at least a first RF magnetic field at a Larmor frequency along a transverse axis to establish an intermediate state of magnetic moment distribution of said nuclei, means for applying to said nuclei a second RF magnetic field at said Larmor frequency along said transverse axis for flipping said nuclei to a desired angle, said first RF magnetic field being defined by Bloch equation using the configuration of said second RF magnetic field, said static magnetic field, said gradient magnetic field, and a desired magnetic moment distribution of said nuclei to establish a residual magnetic moment distribution for said nuclei, and Fourier analysis of said residual magnetic moment distribution, and means for detecting an FID signal from said nuclei.
Claim 10
Dependent Claim
159 words
Apparatus for use in NMR imaging comprising means for applying to nuclei a static magnetic field along a first axis, means for applying to said nuclei a gradient magnetic field along said first axis, means for applying to said nuclei at least a first RF magnetic field at a Larmor frequency along a transverse axis to establish an intermediate state of magnetic moment distribution of said nuclei, means for applying to said nuclei a second RF magnetic field at said Larmor frequency along said transverse axis for flipping said nuclei to a desired angle, said first RF magnetic field being defined by Bloch equation using the configuration of said second RF magnetic field, said static magnetic field, said gradient magnetic field, and a desired magnetic moment distribution of said nuclei to establish a residual magnetic moment distribution for said nuclei, and Fourier analysis of said residual magnetic moment distribution, and means for detecting an FID signal from said nuclei.
Claim 11
Dependent Claim
110 words
For use in NMR imaging, apparatus comprising means for applying first and second pulsed magnetic excitations at a Larmor frequency to nuclei, said first pulsed magnetic excitation flipping said nuclei and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution, said second pulsed magnetic excitation being defined by Bloch equation using the configuration of said first RF magnetic field, the applied static and gradient field, and the desired magnetic moment distribution of the nuclei to establish a residual magnetic moment distribution for the nuclei, and Fourier analysis of said residual magnetic moment distribution.
Claim 12
Dependent Claim
110 words
For use in NMR imaging, apparatus comprising means for applying first and second pulsed magnetic excitations at a Larmor frequency to nuclei, said first pulsed magnetic excitation flipping said nuclei and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution, said second pulsed magnetic excitation being defined by Bloch equation using the configuration of said first RF magnetic field, the applied static and gradient field, and the desired magnetic moment distribution of the nuclei to establish a residual magnetic moment distribution for the nuclei, and Fourier analysis of said residual magnetic moment distribution.
Claim 13
Dependent Claim
134 words
In NMR imaging a method for selectively exciting the magnetic moments of nuclei spins in a desired region comprising the steps of exciting said magnetic moments with an RF magnetic pulse in the presence of a first magnetic gradient field, and exciting said magnetic moments with at least a second RF magnetic pulse in the presence of a second magnetic gradient field, said second RF magnetic pulse having a waveform which corrects for errors introduced by non-linearities of said first excitation, said second RF magnetic pulse being defined by Bloch equation using the configuration of said first RF magnetic field, the applied static and gradient field, and the desired magnetic moment distribution of the nuclei to establish a residual magnetic moment distribution for the nuclei, and Fourier analysis of said residual magnetic moment distribution.
Claim 14
Dependent Claim
134 words
In NMR imaging a method for selectively exciting the magnetic moments of nuclei spins in a desired region comprising the steps of exciting said magnetic moments with an RF magnetic pulse in the presence of a first magnetic gradient field, and exciting said magnetic moments with at least a second RF magnetic pulse in the presence of a second magnetic gradient field, said second RF magnetic pulse having a waveform which corrects for errors introduced by non-linearities of said first excitation, said second RF magnetic pulse being defined by Bloch equation using the configuration of said first RF magnetic field, the applied static and gradient field, and the desired magnetic moment distribution of the nuclei to establish a residual magnetic moment distribution for the nuclei, and Fourier analysis of said residual magnetic moment distribution.
Claim 15
Dependent Claim
17 words
The method as defined by claim 9 wherein said first and second gradients have the same polarity.
Claim 16
Dependent Claim
16 words
The method as defined by claim 9 wherein said first and second gradients have opposite polarity.
Claim 17
Dependent Claim
141 words
For use in NMR imaging wherein a static magnetic field and a gradient magnetic field are imposed on nuclei along a first axis and an RF magnetic field at a Larmor frequency is imposed on said nuclei along a first transverse axis for exciting a selected region of said nuclei and flipping the magnetic moments of said nuclei from the first axis by a desired angle, a method of exciting said nuclei comprising the steps of applying first and second pulsed magnetic excitations at said Larmor frequency, said first pulsed magnetic excitation flipping said nuclei greater than 90° and approximating said desired angle and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution and effecting the flipping of said nuclei to said desired angle.
Claim 18
Dependent Claim
141 words
For use in NMR imaging wherein a static magnetic field and a gradient magnetic field are imposed on nuclei along a first axis and an RF magnetic field at a Larmor frequency is imposed on said nuclei along a first transverse axis for exciting a selected region of said nuclei and flipping the magnetic moments of said nuclei from the first axis by a desired angle, a method of exciting said nuclei comprising the steps of applying first and second pulsed magnetic excitations at said Larmor frequency, said first pulsed magnetic excitation flipping said nuclei greater than 90° and approximating said desired angle and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution and effecting the flipping of said nuclei to said desired angle.
Claim 19
Dependent Claim
76 words
For use in NMR imaging, apparatus comprising means for applying first and second pulsed magnetic excitations at a Larmore frequency to nuclei, said first pulsed magnetic excitation flipping said nuclei greater than 90° and approximating a desired angle and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution and effecting the flipping of said nuclei to said desired angle.
Claim 20
Dependent Claim
76 words
For use in NMR imaging, apparatus comprising means for applying first and second pulsed magnetic excitations at a Larmore frequency to nuclei, said first pulsed magnetic excitation flipping said nuclei greater than 90° and approximating a desired angle and producing an undesired magnetic moment distribution in addition to a desired magnetic moment distribution, said second pulsed magnetic excitation compensating for said undesired magnetic moment distribution and effecting the flipping of said nuclei to said desired angle.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-08 | 1990-12-08 | 1991-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-08 | 1994-12-08 | 1995-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-08 | 1998-12-08 | 1999-06-09 | $7700.00 | Window Closed / Lapsed |