Patent US4670252A successfully refreshed from Google Patents.
US4670252A
Expired / Lapsed
US
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Treatment of oral diseases
Assignee: Procter and Gamble Co
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Filing: 1985-05-24
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Granted: 1987-06-02
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Expires: 2005-05-24
Abstract
Abstract This invention relates to a method for treating or preventing anaerobe infections in humans and lower animals. This invention further relates to compositions and kits useful for treating or preventing anaerobe infections according to the method of the present invention.
Inventors
- 👤 Padmini Sampathkumar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:50
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/38; A61P; A61P1/00; A61P1/02; A61P17/00; A61Q; A61Q11/00; A61Q19/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
46 words
A method of treating or preventing oral cavity, anaerobe infections in humans or lower animals by topically applying to the oral cavity tissue of the human or lower animal being treated, a safe and effective amount of a singlet oxygen generating organic monoperphthalic peroxy acid compound.
Claim 2
Independent Claim
46 words
A method of treating or preventing oral cavity, anaerobe infections in humans or lower animals by topically applying to the oral cavity tissue of the human or lower animal being treated, a safe and effective amount of a singlet oxygen generating organic monoperphthalic peroxy acid compound.
Claim 3
Dependent Claim
74 words
A method according to claim 1 of treating or preventing oral cavity anaerobe infections in humans or lower animals by topically applying to the oral cavity tissue of the human or lower animal being treated, a safe and effective amount of a monoperphthalic acid compound having the general structure: ##STR4## or its pharmaceutically-acceptable salts or esters, wherein R may be one or more substituents compatible with the peroxy acid functionality of the aromatic ring.
Claim 4
Dependent Claim
22 words
A method according to claim 2 wherein the anaerobe infections are dental plaque, or gingival, or periodontal diseases of the oral cavity.
Claim 5
Dependent Claim
51 words
A method according to claim 3 wherein R is selected from the group consisting of hydrogen, substituted and unsubstituted saturated alkyl having from 1 to about 20 carbon atoms, substituted and unsubstituted aryl, substituted and unsubstituted benzyl, chloro, fluoro, nitro, sulphonate, trifluoromethyl, trialkylammonium, cyano, carboxy, carboxylate, percarboxylate, alkoxy, and combinations thereof.
Claim 6
Dependent Claim
43 words
A method according to claim 3 wherein the safe and effective amount of monoperphthalic acid compound which is taken into the oral cavity is from about 5×10 -6 moles to about 5×10 -3 moles, based on the equivalents of peroxide units per compound.
Claim 7
Dependent Claim
32 words
A method according to claim 3 wherein the pH of the oral cavity during topical application of the monoperphthalic acid compound to the gingival tissue is from about pH=5 to about pH=8.
Claim 8
Dependent Claim
22 words
A method according to claim 4 wherein in the monoperphthalic acid compound R=hydrogen, or the pharmaceutically-acceptable salts or esters of that compound.
Claim 9
Dependent Claim
19 words
A method according to claim 7 wherein the monoperphthalic acid salt is the magnesium salt having the formula: ##STR5##
Claim 10
Dependent Claim
46 words
A method according to claim 8 wherein the concentration of the magnesium monoperphthalic acid in the oral cavity is such that the concentration of the active oxygen generated by the magnesium monoperphthalic acid is in the range of from about 30 ppm to about 1200 ppm.
Claim 11
Dependent Claim
22 words
A method according to claim 9 wherein the pH of the oral cavity during treatment is from about pH=7.0 to about pH=7.5.
Claim 12
Dependent Claim
18 words
A method according to claim 8 wherein the disease of the oral cavity is periodontal disease or gingivitis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-06-01 | 1990-12-01 | 1991-06-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-01 | 1994-12-01 | 1995-06-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-01 | 1998-12-01 | 1999-06-02 | $7700.00 | Window Closed / Lapsed |