US4668667A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Acylphosphorotriamides useful as lipid-altering agents
Assignee: Warner Chilcott Pharmaceuticals Inc
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Filing: 1985-08-01
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Granted: 1987-05-26
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Expires: 2005-08-01
Abstract
Abstract The present invention involves compounds of the class of acylphosphorotriamides and methods for altering the blood plasma lipid content of mammals which comprises systemically administering to mammals an effective but nontoxic amount of a composition comprising such compounds.
Inventors
- 👤 Thomas J. Moorehead
- 👤 Allan V. Bayless
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:54
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/22; C07F9/224; A; A61; A61P; A61P3/00; A61P3/06; C07F9/547; C07F9/553; C07F9/576; C07F9/58
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
94 words
A method for reducing the total cholesterol content or the ratio of low density lipoprotein cholesterol to high density lipoprotein cholesterol in the blood plasma of a mammal which comprises systemically administering to such mammal an effective but nontoxic amount of a composition comprising a compound conforming to the following chemical structure: ##STR4## wherein R 2 is H or straight or branched chain lower alkyl and R 1 is phenyl or substituted phenyl, pyridyl or substituted pyridyl, furyl or substituted furyl, naphthyl or substituted naphthyl, benzyl or substituted benzyl, or phenyl(lower)alkyl or substituted phenyl(lower)alkyl.
Claim 2
Independent Claim
94 words
A method for reducing the total cholesterol content or the ratio of low density lipoprotein cholesterol to high density lipoprotein cholesterol in the blood plasma of a mammal which comprises systemically administering to such mammal an effective but nontoxic amount of a composition comprising a compound conforming to the following chemical structure: ##STR4## wherein R 2 is H or straight or branched chain lower alkyl and R 1 is phenyl or substituted phenyl, pyridyl or substituted pyridyl, furyl or substituted furyl, naphthyl or substituted naphthyl, benzyl or substituted benzyl, or phenyl(lower)alkyl or substituted phenyl(lower)alkyl.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein R 2 is H.
Claim 4
Dependent Claim
16 words
The method of claim 2 wherein R 1 is phenyl or substituted phenyl, furyl, or pyridyl.
Claim 5
Dependent Claim
50 words
The method of claim 2 wherein R 1 is 2-furyl, 3-pyridyl, phenyl, or 4-substituted phenyl wherein said phenyl substituent is selected from the group consisting of halo, lower straight or branched chain alkyl, lower straight or branched chain alkoxy, amino, nitro, lower straight or branched chain alkylsulfonyl, cyano, and phenoxy.
Claim 6
Dependent Claim
10 words
The method of claim 2 wherein R 1 is phenyl.
Claim 7
Dependent Claim
10 words
The method of claim 2 wherein R 1 is 4-methoxyphenyl.
Claim 8
Dependent Claim
10 words
The method of claim 2 wherein R 1 is 4-fluorophenyl.
Claim 9
Dependent Claim
10 words
The method of claim 2 wherein R 1 is 3-fluorophenyl.
Claim 10
Dependent Claim
10 words
The method of claim 2 wherein R 1 is 2-fluorophenyl.
Claim 11
Dependent Claim
10 words
The method of claim 2 wherein R 1 is 4-methylphenyl.
Claim 12
Dependent Claim
10 words
The method of claim 2 wherein R 1 is 4-aminophenyl.
Claim 13
Independent Claim
83 words
A method for inhibiting the activity of pseudocholinesterase in the blood plasma of a mammal having hyperlipidemia which comprises systemically administering to such mammal an effective but nontoxic amount of a composition comprising a compound conforming to the following chemical structure: ##STR5## wherein R 2 is H or straight or branched chain lower alkyl and R 1 is phenyl or substituted phenyl, pyridyl or substituted pyridyl, furyl or substituted furyl, naphthyl or substituted naphthyl, benzyl or substituted benzyl, or phenyl(lower)alkyl or substituted phenyl(lower)alkyl.
Claim 14
Independent Claim
83 words
A method for inhibiting the activity of pseudocholinesterase in the blood plasma of a mammal having hyperlipidemia which comprises systemically administering to such mammal an effective but nontoxic amount of a composition comprising a compound conforming to the following chemical structure: ##STR5## wherein R 2 is H or straight or branched chain lower alkyl and R 1 is phenyl or substituted phenyl, pyridyl or substituted pyridyl, furyl or substituted furyl, naphthyl or substituted naphthyl, benzyl or substituted benzyl, or phenyl(lower)alkyl or substituted phenyl(lower)alkyl.
Claim 15
Dependent Claim
10 words
The method of claim 12 wherein R 2 is H.
Claim 16
Dependent Claim
16 words
The method of claim 13 wherein R 1 is phenyl or substituted phenyl, furyl, or pyridyl.
Claim 17
Dependent Claim
50 words
The method of claim 13 wherein R 1 is 2-furyl, 3-pyridyl, phenyl, or 4-substituted phenyl wherein said phenyl substituent is selected from the group consisting of halo, lower straight or branched chain alkyl, lower straight or branched chain alkoxy, amino, nitro, lower straight or branched chain alkylsulfonyl, cyano, and phenoxy.
Claim 18
Dependent Claim
10 words
The method of claim 13 wherein R 1 is 4-fluorophenyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-25 | 1990-11-24 | 1991-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-25 | 1994-11-24 | 1995-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-25 | 1998-11-24 | 1999-05-26 | $7700.00 | Window Closed / Lapsed |