US4454126A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phosphoramide derivatives and medicines containing the same
Assignee: Eisai Co Ltd
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Filing: 1982-10-15
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Granted: 1984-06-12
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Expires: 2002-10-15
Abstract
Abstract Phosphoramide derivatives of the general formula: <IMAGE> are disclosed wherein X and Y each represents a hydrogen atom or X and Y are removed to form a double bond between the respective adjoining carbon atoms, and n represents an integer of 0 to 2. A process for the preparation of these compounds and pharmaceutical compositions containing these phosphoramide derivatives are also disclosed. The phosphoramide derivatives of the invention are used to treat urethral calculosis and pyelonephritis.
Inventors
- 👤 Isao Yamatsu
- 👤 Yuichi Inai
- 👤 Takeshi Suzuki
- 👤 Shinya Abe
- 👤 Masaru Satoh
- 👤 Naosuke Seto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:25
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/22; C07F9/222; A; A61; A61P; A61P13/00; A61P13/02; A61P15/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
43 words
A compound having the formula: ##STR16## wherein X and Y each represents hydrogen or X and Y together form a valence bond between the two adjacent carbon atoms to which they are respectively attached, and n represents an integer of 0 to 2.
Claim 2
Dependent Claim
43 words
A compound having the formula: ##STR16## wherein X and Y each represents hydrogen or X and Y together form a valence bond between the two adjacent carbon atoms to which they are respectively attached, and n represents an integer of 0 to 2.
Claim 3
Dependent Claim
9 words
A compound according to claim 1 which is N-(diaminphosphinyl)-3-methyl-2-butenamide.
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is N-(diaminophosphinyl)-3-methyl-butanamide.
Claim 5
Dependent Claim
9 words
A compound according to claim 1 which is N-(diaminophosphinyl)-3,7-dimethyl-2-octenamide.
Claim 6
Dependent Claim
10 words
A compound according to claim 1 which is N-(diaminophosphinyl)-3,7-dimethyl octanamide.
Claim 7
Dependent Claim
9 words
A compound according to claim 1 which is N-(diaminophosphinyl)-3,7,11-trimethyl-2-dodecenamide.
Claim 8
Dependent Claim
9 words
A compound according to claim 1 which is N-(diaminophosphinyl)-3,7,11-trimethyldodecanamide.
Claim 9
Dependent Claim
67 words
A pharmaceutical composition for the treatment of urethral calculosis comprising an effective amount of a phosphoramide derivative of the formula: ##STR17## wherein X and Y each represents hydrogen or X and Y together form a double bond between the two adjacent carbon atoms to which they are respectively attached, and n represents an integer of 0 to 2, as an active ingredient, and a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
67 words
A pharmaceutical composition for the treatment of urethral calculosis comprising an effective amount of a phosphoramide derivative of the formula: ##STR17## wherein X and Y each represents hydrogen or X and Y together form a double bond between the two adjacent carbon atoms to which they are respectively attached, and n represents an integer of 0 to 2, as an active ingredient, and a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
74 words
A pharmaceutical composition for the treatment of pyelonephritis caused by a urethral infection of urease-producing bacteria comprising an effective amount of a phosphoramide derivative of the formula: ##STR18## wherein X and Y each represents hydrogen or X and Y together form a double bond between the two adjacent carbon atoms to which they are respectively attached, and n represents an integer of 0 to 2, as an active ingredient, and a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
74 words
A pharmaceutical composition for the treatment of pyelonephritis caused by a urethral infection of urease-producing bacteria comprising an effective amount of a phosphoramide derivative of the formula: ##STR18## wherein X and Y each represents hydrogen or X and Y together form a double bond between the two adjacent carbon atoms to which they are respectively attached, and n represents an integer of 0 to 2, as an active ingredient, and a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
29 words
A method of treating a patient afflicted with urethral calculosis which comprises administering to said patient a therapeutically effective amount of a pharmaceutical composition as claimed in claim 8.
Claim 14
Dependent Claim
28 words
A method of treating a patient afflicted with pyelonephritis which comprises administering to said patient a therapeutically effective amount of a pharmaceutical composition as claimed in claim 9.
References Cited (Backward Citations)
US3962433A
Cited
US4182881A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-06-12 | 1987-12-12 | 1988-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-06-12 | 1991-12-12 | 1992-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-06-12 | 1995-12-12 | 1996-06-12 | $7700.00 | Window Closed / Lapsed |