Patent US4668664A successfully refreshed from Google Patents.
US4668664A
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Bi- or tri-enic fatty esters of erythromycin A; pharmaceutical and cosmetic compositions containing them
Assignee: L'Oréal SA
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Filing: 1986-05-14
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Granted: 1987-05-26
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Expires: 2006-05-14
Abstract
Abstract Linear bi- or tri-enic fatty esters of erythromycin A have the formula <IMAGE> wherein one of R and R' represents a linear bi- or tri-enic C18 acyl radical having an all cis (Z) stereochemical configuration and the other of R and R' represents hydrogen.
Inventors
- 👤 Andr/e/ Rougier
- 👤 Didier Dupuis
- 👤 Michel Philippe
- 👤 Henri Sebag
- 👤 Didier S. Leger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:00
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P17/00; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
50 words
A linear bi- or tri-enic fatty ester of erythromycin A having the formula ##STR3## wherein one of R and R' represents a linear bi- or tri-enic C 18 acyl radical having an all cis (Z) stereochemical configuration and the other of R and R' represents hydrogen; and the salts therof.
Claim 2
Dependent Claim
50 words
A linear bi- or tri-enic fatty ester of erythromycin A having the formula ##STR3## wherein one of R and R' represents a linear bi- or tri-enic C 18 acyl radical having an all cis (Z) stereochemical configuration and the other of R and R' represents hydrogen; and the salts therof.
Claim 3
Dependent Claim
25 words
The linear bi- or tri-enic fatty ester of claim 1 wherein R or R' represents Z-9,Z-12-octadecadienoyl or linoleoyl, Z-9,Z-12,Z-15-octadecatrienoyl or α-linolenoyl and Z-6,Z-9,Z-12-octadecatrienoyl or γ-linolenoyl.
Claim 4
Dependent Claim
26 words
The linear bi- or tri-enic fatty ester of claim 1 selected from 1' O-linolenoyl-2' erythromycin A, 1' O-linolenoyl-4" erythromycin A and 1' O-α linolenoyl-4" erythromycin A.
Claim 5
Dependent Claim
30 words
A pharmaceutical composition for the treatment of dermatoses comprising in an anhydrous vehicle an effective amount of the linear bi- or tri-enic fatty ester of erythromycin A of claim 1.
Claim 6
Dependent Claim
28 words
The composition of claim 4 wherein said ester is present in an amount ranging from 0.1 to 5 weight percent based on the total weight of said composition.
Claim 7
Dependent Claim
28 words
The composition of claim 4 wherein said ester is present in an amount ranging from 2 to 3 weight percent based on the total weight of said composition.
Claim 8
Dependent Claim
34 words
The composition of claim 4 wherein said vehicle is acetone, isopropyl alcohol, triglycerides of fatty acids, glycol ethers, C 1 -C 4 alkyl esters of short chain acids, polytetrahydrofuran ethers, or a mixture thereof.
Claim 9
Dependent Claim
30 words
The composition of claim 4 which also contains a thickening agent present in an amount ranging from 0.5 to 20 weight percent based on the total weight of said composition.
Claim 10
Dependent Claim
14 words
The composition of claim 8 wherein said thickening agent is cellulose or hydroxypropyl cellulose.
Claim 11
Dependent Claim
16 words
The composition of claim 4 which also contains an antioxidant, a preservative, a perfume, or dye.
References Cited (Backward Citations)
US2862921A
Cited
US4575497A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-25 | 1990-11-24 | 1991-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-25 | 1994-11-24 | 1995-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-25 | 1998-11-24 | 1999-05-26 | $7700.00 | Window Closed / Lapsed |