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US4668662A
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Polypeptides with an anticoagulant action, a process to prepare or obtain them, their use and agents containing them
Assignee: Bayer Pharma AG
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Filing: 1985-04-17
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Granted: 1987-05-26
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Expires: 2005-04-17
Abstract
Abstract The invention relates to polypeptides of the formula I ##STR1## in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring α-amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring α-amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.
Inventors
- 👤 Dominique Tripier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:35
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/06; C07K14/00; C07K14/81; C07K14/815; A; A61; A61P; A61P7/00; A61P7/02; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/26
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
54 words
A polypeptide of the formula I ##STR4## wherein R denotes the phenolic hydrogen or a phenol ester group, and Y denotes Val, Ile, Thr, Leu or Phe, and in which the six Cys residues at positions 5, 13, 15, 21, 27 and 38 are linked pairwise via disulfide bridges, and its physiologically tolerated salts.
Claim 2
Dependent Claim
54 words
A polypeptide of the formula I ##STR4## wherein R denotes the phenolic hydrogen or a phenol ester group, and Y denotes Val, Ile, Thr, Leu or Phe, and in which the six Cys residues at positions 5, 13, 15, 21, 27 and 38 are linked pairwise via disulfide bridges, and its physiologically tolerated salts.
Claim 3
Dependent Claim
18 words
The polypeptide of claim 1, wherein R denotes hydrogen, SO 3 H or PO 3 H 2 .
Claim 4
Dependent Claim
9 words
The polypeptide of claim 1 wherein Y denotes Thr.
Claim 5
Dependent Claim
37 words
A pharmaceutical agent for treating thromboembolic process containing a polypeptide of the formula I as claimed in claim 1, or its physiologically tolerated salt, in an amount which is effective for anticoagulation, and a pharmaceutically acceptable vehicle.
Claim 6
Dependent Claim
26 words
A method for the treatment of thromboembolic processes comprising administering an effective amount of polypeptide as claimed in claim 1 or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-25 | 1990-11-24 | 1991-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-25 | 1994-11-24 | 1995-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-25 | 1998-11-24 | 1999-05-26 | $7700.00 | Window Closed / Lapsed |