Propylphenoxy pyridine carboxylates as leukotriene antagonists

Claim 1

A Compound having the formula: ##STR38## wherein: each Y is independently selected from CR or N, but at least one Y but not both must be N; each n is independently 0 to 6: each R independently represents H, alkyl of 1 to 6 carbon atoms which is straight chain or branched, alkenyl of 2 to 6 carbon atoms which is straight chain or branched, trifluoromethyl, alkoxy of 1 to 6 carbon atoms which is straight chain or branched, SH, thioalkyl of 1 to 6 carbon atoms which is straight chain or branched, halogen, OH, amino, N(R 4 ) 2 , COOR 4 , CH 2 OR 4 , formyl, CN, trifluoromethylthio, or nitro (with the proviso that both R groups are not simultaneously OH, amino, N(R 4 ) 2 , COOR 4 , CH 2 OR 4 , formyl, CN, trifluoromethylthio, or nitro); R' is H, alkyl of 1 to 6 carbon atoms which is straight chain or branched, alkenyl of 2 to 6 carbon atoms which is straight chain or branched, trifluoromethyl, alkoxy of 1 to 6 carbon atoms which is straight chain or branched, thioalkyl of 1 to 6 carbon atoms which is straight chain or branched, halogen, or trifluoromethylthio; R 1 is H, alkyl of 1 to 6 carbon atoms which is straight chain or branched, or alkoxy of 1 to 6 carbon atoms which is straight chain or branched; R 2 is H, alkyl of 1 to 6 carbon atoms which is straight chain or branched, R 4 CO, or R 4 OCH 2 ; R 3 is alkyl of 1 to 6 carbon atoms which is straight chain or branched, alkenyl of 3 to 6 carbon atoms which is straight chain or branched, phenyl, or phenyl substituted by one or more R; R 4 is independently H or alkyl of 1 to 6 carbon atoms which is straight chain or branched; R 5 is independently H, OH, alkyl of 1 to 4 carbons, or both R 5 's are combined to create a doubly bonded oxygen (═O); X 1 and X 2 are each independently oxygen, sulfur, sulfoxide, or sulfone; and a pharmaceutically acceptable salt or acid addition salt thereof.