US4219477A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Penicillin derivatives
Assignee: Nippon Chemiphar Co Ltd
•
Filing: 1978-12-05
•
Granted: 1980-08-26
•
Expires: 1998-12-05
Abstract
Abstract Penicillin and cephalosporin derivatives and non-toxic salts thereof represented by the formula (1), ##STR1## wherein Ar represents a phenyl or heterocyclic group which may be substituted by a halogen atom, or a hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N, ##STR2## 1 and n are integers of 0 or 1 wherein the sum equal to 1 and n is 0 or 1, and m is an integer equal to 1 or 2 are useful antibiotics.
Inventors
- 👤 Yasuo Fujimoto
- 👤 Yasuo Kishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:16
CPC Classifications
C; C07; C07D; C07D499/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
81 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (I). ##STR62## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N, l and n are integers equal to 0 or 1 wherein the sum of l and n is 0 or 1, and m is an integer equal to 1 or 2.
Claim 2
Dependent Claim
81 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (I). ##STR62## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N, l and n are integers equal to 0 or 1 wherein the sum of l and n is 0 or 1, and m is an integer equal to 1 or 2.
Claim 3
Dependent Claim
50 words
Penicillin derivatives and non-toxic salt thereof represented by the formula (II), ##STR63## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 4
Dependent Claim
50 words
Penicillin derivatives and non-toxic salt thereof represented by the formula (II), ##STR63## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 5
Dependent Claim
10 words
The compound of claim 2 which is D(-)-α-(chalcone-4-carboxamido)-benzylpenicillin potassium salt.
Claim 6
Dependent Claim
11 words
The compound of claim 2 which is D(-)-α-(chalcone-4-carboxamido)-p-hydroxy benzylpenicillin potassium salt.
Claim 7
Dependent Claim
51 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (III), ##STR64## wherein Ar represents a phenyl or heterocyclic furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 8
Dependent Claim
51 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (III), ##STR64## wherein Ar represents a phenyl or heterocyclic furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 9
Dependent Claim
11 words
The compound of claim 5 which is D(-)-α-(2-chlorochalcone-4'-carboxamido) benzylpenicillin sodium salt.
Claim 10
Dependent Claim
11 words
The compound of claim 5 which is D(-)-α-(4-chlorochalcone-4'-carboxamido) benzylpenicillin sodium salt.
Claim 11
Dependent Claim
11 words
The compound of claim 5 which is D(-)-α-(4-chlorochalcone-4'-carboxamido) p-hydroxybenzylpenicillin sodium salt.
Claim 12
Dependent Claim
10 words
The compound of claim 5 which is D(-)-α-[p-[β-(2-thienyl)acryloyl]benzamido]benzylpenicillin sodium salt.
Claim 13
Dependent Claim
10 words
The compound of claim 5 which is D(-)-α-[p-[β-(2-pyridyl)acryloyl]benzamido]benzylpenicillin sodium salt.
Claim 14
Dependent Claim
50 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (IV). ##STR65## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 15
Dependent Claim
50 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (IV). ##STR65## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 16
Dependent Claim
10 words
The compound of claim 11 which is D(-)-α-(p-styrylbenzamido)-benzylpenicillin sodium salt.
Claim 17
Dependent Claim
11 words
The compound of claim 11 which is D(-)-α-(p-styrylbenzamido)p-hydroxy benzylpenicillin sodium salt.
Claim 18
Dependent Claim
50 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (V), ##STR66## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 19
Dependent Claim
50 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (V), ##STR66## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 20
Dependent Claim
10 words
The compound of claim 14 which is D(-)-α-[p-(5-phenylpenta-2,4-dienoyl)benzamido]benzylpenicillin sodium salt.
Claim 21
Dependent Claim
50 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (VI), ##STR67## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
Claim 22
Dependent Claim
50 words
Penicillin derivatives and non-toxic salts thereof represented by the formula (VI), ##STR67## wherein Ar represents a phenyl or furyl, thienyl or pyridyl group which may be substituted by a halogen atom, hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-26 | 1984-02-25 | 1984-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-26 | 1988-02-25 | 1988-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-26 | 1992-02-25 | 1992-08-26 | $7700.00 | Window Closed / Lapsed |