US4666897A
Expired / Lapsed
US
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Inhibition of mammalian collagenolytic enzymes by tetracyclines
Assignee: Research Foundation of the State University of New York
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Filing: 1983-12-29
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Granted: 1987-05-19
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Expires: 2003-12-29
Abstract
Abstract A method of reducing pathologically excessive levels of activity of collagenolytic enzymes in mammals to substantially normal levels by administering 10-100% of the normal antibiotic therapeutic dose of a tetracycline is disclosed.
Inventors
- 👤 Lorne M. Golub
- 👤 Thomas F. McNamara
- 👤 N. S. Ramamurthy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/65
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
52 words
A method of reducing a pathological excess of mammalian collagenolytic enzyme(s) activity in a mammalian system to substantially normal levels which comprises administering to a mammal in need of anti-collagenolytic therapy an amount of a tetracycline which is therapeutically effective in reducing the level of collagenolytic activity substantially to said normal level.
Claim 2
Independent Claim
52 words
A method of reducing a pathological excess of mammalian collagenolytic enzyme(s) activity in a mammalian system to substantially normal levels which comprises administering to a mammal in need of anti-collagenolytic therapy an amount of a tetracycline which is therapeutically effective in reducing the level of collagenolytic activity substantially to said normal level.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein the tetracycline administered is tetracycline.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein the tetracycline administered is minocycline.
Claim 5
Dependent Claim
12 words
A method according to claim 1 wherein the tetracycline administered is doxycycline.
Claim 6
Dependent Claim
19 words
A method according to claim 1 wherein the pathological excess mammalian collagenolytic activity is manifested by excessive bone resorption.
Claim 7
Dependent Claim
18 words
A method according to claim 1 wherein the pathological excess mammalian collagenolytic activity is manifested by periodontal disease.
Claim 8
Dependent Claim
18 words
A method according to claim 1 wherein the pathological excess mammalian collagenolytic activity is manifested by rheumatoid arthritis.
Claim 9
Dependent Claim
20 words
A method according to claim 1 wherein the pathological excess mammalian collagenolytic activity is manifested by ulceration of the cornea.
Claim 10
Dependent Claim
25 words
A method according to claim 1 wherein the pathological excess mammalian collagenolytic activity is manifested by the resorption of skin or other connective tissue collagen.
Claim 11
Dependent Claim
25 words
A method according to claim 1 wherein the amount of the tetracycline administered is from 10-100% of the normal antibiotic therapeutic dose of the tetracycline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-18 | 1990-11-17 | 1991-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-18 | 1994-11-17 | 1995-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-18 | 1998-11-17 | 1999-05-19 | $7700.00 | Window Closed / Lapsed |