US4457936A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of hydroxyphenyl-thiazole-, -thiazoline- and -thiazolidine-carboxylic acids, for influencing the collagen metabolism
Assignee: Hoechst AG
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Filing: 1982-04-07
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Granted: 1984-07-03
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Expires: 2002-04-07
Abstract
Abstract What are disclosed are hydroxyphenyl-thiazole-, -thiazoline- and -thiazolidine-carboxylic acids of the formulae ##STR1## in which R 1 and R 3 , independently from each other, are hydrogen, methyl, chlorine or bromine, and R 1 and R 3 may alternatively be nitro, amino or sulfonylamido; R 2 is hydrogen, hydroxyl or methyl; R 4 is hydrogen or methyl; and R 5 is hydrogen, methyl, phenyl or --COOH; and their salts with physiologically acceptable bases, a process for the preparation thereof and their use for influencing the collagen metabolism.
Inventors
- 👤 Eberhard Draeger
- 👤 Henning Lubbers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:40
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/08; C07D277/12; A; A61; A61P; A61P3/00; C07D277/04; C07D277/06; C07D277/20; C07D277/32; C07D277/56
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
119 words
A pharmaceutical preparation for inhibiting collagen biosynthesis which comprises an effective inhibiting amount of a carboxylic acid selected from the group of acids having the formulas ##STR25## or a soluble, physiologically acceptable carboxylate salt of such an acid, formed with a base, wherein R 1 and R 3 independently of each other are hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro, amino, or sulfonylamido; R 2 is hydrogen, hydroxyl, or methyl; R 4 is hydrogen or methyl, but not all of R 1 -R 4 are hydrogen; and R 5 is hydrogen, methyl, phenyl, or carboxyl, together with a pharmaceutically acceptable carrier therefor.
Claim 2
Dependent Claim
119 words
A pharmaceutical preparation for inhibiting collagen biosynthesis which comprises an effective inhibiting amount of a carboxylic acid selected from the group of acids having the formulas ##STR25## or a soluble, physiologically acceptable carboxylate salt of such an acid, formed with a base, wherein R 1 and R 3 independently of each other are hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro, amino, or sulfonylamido; R 2 is hydrogen, hydroxyl, or methyl; R 4 is hydrogen or methyl, but not all of R 1 -R 4 are hydrogen; and R 5 is hydrogen, methyl, phenyl, or carboxyl, together with a pharmaceutically acceptable carrier therefor.
Claim 3
Independent Claim
122 words
A method for inhibiting collagen biosynthesis in a patient requiring such treatment, which method comprises administering to said patient an effective inhibiting amount of a carboxylic acid selected from the group of acids having the formulas ##STR26## or a soluble, physiologically acceptable carboxylate salt of such an acid, formed with a base, wherein R 1 and R 3 independently of each other are hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro, amino, or sulfonylamido; R 2 is hydrogen, hydroxyl, or methyl; R 4 is hydrogen or methyl, but not all of R 1 -R 4 are hydrogen; and R 5 is hydrogen, methyl, phenyl, or carboxyl.
Claim 4
Independent Claim
122 words
A method for inhibiting collagen biosynthesis in a patient requiring such treatment, which method comprises administering to said patient an effective inhibiting amount of a carboxylic acid selected from the group of acids having the formulas ##STR26## or a soluble, physiologically acceptable carboxylate salt of such an acid, formed with a base, wherein R 1 and R 3 independently of each other are hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro, amino, or sulfonylamido; R 2 is hydrogen, hydroxyl, or methyl; R 4 is hydrogen or methyl, but not all of R 1 -R 4 are hydrogen; and R 5 is hydrogen, methyl, phenyl, or carboxyl.
Claim 5
Dependent Claim
91 words
A pharmaceutical preparation for inhibiting collagen biosynthesis which comprises an effective inhibiting amount of a carboxylic acid of the formula ##STR27## or of a soluble, physiologically acceptable, carboxylate salt of such an acid formed with a base, wherein R 1 , R 3 , and R 4 are, independently of each other, hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro; and R 2 is hydrogen, methyl, or hydroxyl; together with a pharmaceutically acceptable carrier therefor.
Claim 6
Dependent Claim
91 words
A pharmaceutical preparation for inhibiting collagen biosynthesis which comprises an effective inhibiting amount of a carboxylic acid of the formula ##STR27## or of a soluble, physiologically acceptable, carboxylate salt of such an acid formed with a base, wherein R 1 , R 3 , and R 4 are, independently of each other, hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro; and R 2 is hydrogen, methyl, or hydroxyl; together with a pharmaceutically acceptable carrier therefor.
Claim 7
Independent Claim
94 words
A method for inhibiting collagen biosynthesis in a patient requiring such treatment, which method comprises administering to said patient an effective inhibiting amount of a carboxylic acid of the formula ##STR28## or of a soluble, physiologically acceptable, carboxylate salt of such an acid formed with a base, wherein R 1 , R 3 , and R 4 are, independently of each other, hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro; and R 2 is hydrogen, methyl, or hydroxyl.
Claim 8
Independent Claim
94 words
A method for inhibiting collagen biosynthesis in a patient requiring such treatment, which method comprises administering to said patient an effective inhibiting amount of a carboxylic acid of the formula ##STR28## or of a soluble, physiologically acceptable, carboxylate salt of such an acid formed with a base, wherein R 1 , R 3 , and R 4 are, independently of each other, hydrogen, methyl, chlorine, or bromine, or one of R 1 or R 3 is hydrogen, methyl, chlorine, or bromine and the other is nitro; and R 2 is hydrogen, methyl, or hydroxyl.
References Cited (Backward Citations)
US3809754A
Cited
US3882110A
Cited
GB1292170A
Cited
FR2062120A5
Cited
GB1382887A
Cited
FR2247243A2
Cited
DE2245560A1
Cited
GB1584981A
Cited
DE3002989A1
Cited
US4367233A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-07-03 | 1988-01-02 | 1988-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-07-03 | 1992-01-02 | 1992-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-07-03 | 1996-01-02 | 1996-07-03 | $7700.00 | Window Closed / Lapsed |