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US4663446A Expired / Lapsed US ⏱️ 0.0 years remaining

N2 (phenyl substituted) deoxy guanosine containing compounds

Assignee: TRUSTEES OF UNIVERSITY OF MASSACHUSETTS AMHERST MASSACHUSETTS A CORP OF
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Filing: 1983-06-27
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Granted: 1987-05-05
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Expires: 2003-06-27
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Abstract

Abstract New purine compounds having the formula: ##STR1## Y and Y'=H, ##STR2## X=H, alkyl, halo; ##STR3## A=O, S, NH 2 are provided. These compounds are useful in treating patients having cancer, since they are potent and selective inhibitors of replicative DNA synthesis in mammalian cells since they inhibit DNA polymerase α. New purine compounds also are provided having the formula: ##STR4## wherein Y, A, Z are as defined above, X'=C 2 H 5 Y"=--CH 3 or ##STR5## These compounds are useful to prevent bacterial growth since they are potent inhibitors of DNA polymerase III. New Purine compounds also are provided having the formula: ##STR6## wherein Z' is H, OH or CH 2 OH, A' is O of CH 2 X"=H, alkyl, halo E=n-butyl, alkyl, halo, H G= ##STR7##

Inventors

  • 👤 George E. Wright

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 18:13
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; C07H19/20

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 23 words
A compound capable of inhibiting the activity of DNA polymerase having the formula: ##STR18## wherein X=H, alkyl, or halo; Y and Y'= ##STR19##
Claim 2
Dependent Claim 23 words
A compound capable of inhibiting the activity of DNA polymerase having the formula: ##STR18## wherein X=H, alkyl, or halo; Y and Y'= ##STR19##
Claim 3
Dependent Claim 33 words
A compound capable of inhibiting the activity of DNA polymerase III having the formula: ##STR20## wherein Y=H, or ##STR21## A=O, S, NH 2 ; X'=C 2 H 5 ; Y"=--CH 3 or ##STR22##
Claim 4
Dependent Claim 33 words
A compound capable of inhibiting the activity of DNA polymerase III having the formula: ##STR20## wherein Y=H, or ##STR21## A=O, S, NH 2 ; X'=C 2 H 5 ; Y"=--CH 3 or ##STR22##
Claim 5
Dependent Claim 52 words
A compound capable of inhibiting the activity of viral DNA polymerase having the formula: ##STR23## wherein A' is O or NH 2 ; X"=H, alkyl, halo; E=alkyl, halo, H wherein E and X" are not H simultaneously ##STR24## wherein Z' is H, OH, or CH 2 OH, ##STR25## and wherein Z=H, ##STR26##
Claim 6
Dependent Claim 52 words
A compound capable of inhibiting the activity of viral DNA polymerase having the formula: ##STR23## wherein A' is O or NH 2 ; X"=H, alkyl, halo; E=alkyl, halo, H wherein E and X" are not H simultaneously ##STR24## wherein Z' is H, OH, or CH 2 OH, ##STR25## and wherein Z=H, ##STR26##

References Cited (Backward Citations)

US3480613A Cited
US3936439A Cited
US4267171A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1990-05-04 1990-11-03 1991-05-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1994-05-04 1994-11-03 1995-05-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1998-05-04 1998-11-03 1999-05-05 $7700.00 Window Closed / Lapsed

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