7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease

Claim 1

A compound having the structure ##STR99## including all stereoisomers thereof, wherein m is 0 to 4; A is --CH═CH-- or --CH 2 --CH 2 --; n is 1 to 5; R is CO 2 H, CO 2 alkyl, CO 2 alkali metal, CO 2 polyhydroxyamine salt ##STR100## wherein R 4 and R 5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl at least one of R 4 and R 5 being other than hydroxy and lower alkoxy; R 1 is H, lower alkyl or aryl; q is 1 to 6; X is ##STR101## wherein R 3 is H or lower alkyl; and R 2 is lower alkyl, lower alkenyl containing 2 to 12 carbons, lower alkynyl containing 2 to 12 carbons, aryl, arylalkyl, lower alkoxy, aralkyloxy, cycloalkyl or cycloalkylalkyl, with the proviso that when X is ##STR102## q is 1; (CH 2 ) m and (CH 2 ) n may be unsubstituted or substituted with 1 or 2 lower alkyl groups and/or 1 or 2 halogens; (CH 2 ) q may be unsubstituted or substituted by 1 or 2 halo, hydroxy, alkoxy, amine, alkylamine, arylamine, thiol, alkylthio, arylthio, cyano, or nitro groups; wherein lower alkyl or alkyl alone or as part of another group containing 1 to 12 carbons and is unsubstituted or is substituted with halo, CF 3 , alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl, alkylcycloalkyl, hydroxy, alkylamino, alkanoylamino, arylcarbonylamino, nitro, cyano, thiol or alkylthio; aryl alone or as part of another group contains 6 to 10 carbons in the ring portion and is unsubstituted or is substituted with 1 or 2 lower alkyl groups, 1 or 2 halogens, 1 or 2 alkoxy groups, 1 or 2 hydroxy groups, 1 or 2 alkylamino groups, 1 or 2 alkanoylamino groups, 1 or 2 arylcarbonylamino groups, 1 or 2 amino groups, 1 or 2 nitro groups, 1 or 2 cyano groups, 1 or 2 thiol groups and/or 1 or 2 alkylthio groups; cycloalkyl alone or as part of another group contains 3 to 12 carbons and is unsubstituted or is substituted with 1 or 2 halogens, 1 or 2 lower alkyl groups, 1 or 2 lower alkoxy groups, 1 or 2 hydroxy groups, 1 or 2 alkylamino groups, 1 or 2 alkanoylamino groups, 1 or 2 arylcarbonylamino groups, 1 or 2 amino groups, 1 or 2 nitro groups, 1 or 2 cyano groups, 1 or 2 thiol groups and/or 1 or 2 alkylthio groups; and alkanoyl refers to lower alkyl linked to a carbonyl group.