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US4659692A
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Cationic oligopeptides having microbicidal activity
Assignee: University of California Berkeley
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Filing: 1984-05-11
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Granted: 1987-04-21
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Expires: 2004-05-11
Abstract
Abstract Novel microbicidal compositions are provided which find use as preservatives, disinfectants, antigens and the like. Particularly, cationic oligopeptides of up to about thirty-five amino acids are provided having amino acid sequences substantially comparable to the amino acid sequences of cationic oligopeptides produced by macrophage. A conserved framework structure is provided. The invention described herein was in the course, or under a grant from the United States Public Health Service and the National Institutes of Health.
Inventors
- 👤 Robert I. Lehrer
- 👤 Michael E. Selsted
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:48
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4723; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/19
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
195 words
A method for inhibiting microbial growth in an environment susceptible to said microbial growth, said method comprising: administering to said environment a microbial growth inhibiting amount of a cationic oligopetide of not more than about 35 amino acids having a sequence of the formula: ##STR7## wherein: aa 1 is val or gly; aa 2 is val, ile, arg, ser or phe; aa 4 is ala val or thr; aa 7 is arg, lys or gly; aa 9 is leu, 21eu, phe or ser; aa 11 is leu, pro, ser or gly; aa 12 is pro, asn, lys, phe or ser; aa 13 is arg, leu, ser or gly; aa 16 is arg, phe or ala; aa 17 is ala, ser or ile; aa 19 is phe, tyr, asp or ser; aa 21 is arg, lys or thr; aa 22 is ile or val; aa 23 is arg or asn; aa 25 is arg, ala or val; aa 26 is ile or arg; aa 27 is his, val or phe; aa 28 is pro, tyr or thr; aa 29 is leu, arg or phe; aa 32 is arg, ser or pro; and w is -02 arg.
Claim 2
Independent Claim
195 words
A method for inhibiting microbial growth in an environment susceptible to said microbial growth, said method comprising: administering to said environment a microbial growth inhibiting amount of a cationic oligopetide of not more than about 35 amino acids having a sequence of the formula: ##STR7## wherein: aa 1 is val or gly; aa 2 is val, ile, arg, ser or phe; aa 4 is ala val or thr; aa 7 is arg, lys or gly; aa 9 is leu, 21eu, phe or ser; aa 11 is leu, pro, ser or gly; aa 12 is pro, asn, lys, phe or ser; aa 13 is arg, leu, ser or gly; aa 16 is arg, phe or ala; aa 17 is ala, ser or ile; aa 19 is phe, tyr, asp or ser; aa 21 is arg, lys or thr; aa 22 is ile or val; aa 23 is arg or asn; aa 25 is arg, ala or val; aa 26 is ile or arg; aa 27 is his, val or phe; aa 28 is pro, tyr or thr; aa 29 is leu, arg or phe; aa 32 is arg, ser or pro; and w is -02 arg.
Claim 3
Dependent Claim
30 words
A method according to claim 1, wherein said cationic oligopeptide is of the formula: ##STR8## where when two amino acids are indicated, either one may be employed at the position.
Claim 4
Dependent Claim
30 words
A method according to claim 1, wherein said cationic oligopeptide is of the formula: ##STR9## where when two amino acids are indicated, either one may be employed at the position.
Claim 5
Dependent Claim
32 words
A method according to claim 1, wherein said cationic oligopeptide is of the formula: ##STR10## wherein where two amino acids are indicated at a particular position, either amino acid may be employed.
Claim 6
Dependent Claim
15 words
A method according to claim 4, wherein said cationic oligopeptide is of the formula: ##STR11##
Claim 7
Dependent Claim
14 words
A method according to claim 4, wherein cationic oligopeptide is of the formula: ##STR12##
Claim 8
Dependent Claim
151 words
A cationic oligopeptide having antimicrobial activity and of from 32 to 34 amino acids and of the formula: ##STR13## wherein: aa 1 is val or gly; aa 2 is val, ile, arg, ser or phe; aa 4 is ala, val or thr; aa 7 is arg, lys or gly; aa 9 is leu, 21eu, phe or ser; aa 11 is leu, pro, ser or gly; aa 12 is pro, asn, lys, phe or ser; aa 13 is arg, leu, ser or gly; aa 16 is arg, phe or ala; aa 17 is ala, ser or ile; aa 19 is phe, tyr, asp or ser; aa 22 is ile or val; aa 23 is arg or asn; aa 25 is arg, ala or val; aa 26 is ile or arg; aa 27 is his, val or phe; aa 28 is pro, tyr or thr; and aa 29 is leu, arg or phe.
Claim 9
Dependent Claim
151 words
A cationic oligopeptide having antimicrobial activity and of from 32 to 34 amino acids and of the formula: ##STR13## wherein: aa 1 is val or gly; aa 2 is val, ile, arg, ser or phe; aa 4 is ala, val or thr; aa 7 is arg, lys or gly; aa 9 is leu, 21eu, phe or ser; aa 11 is leu, pro, ser or gly; aa 12 is pro, asn, lys, phe or ser; aa 13 is arg, leu, ser or gly; aa 16 is arg, phe or ala; aa 17 is ala, ser or ile; aa 19 is phe, tyr, asp or ser; aa 22 is ile or val; aa 23 is arg or asn; aa 25 is arg, ala or val; aa 26 is ile or arg; aa 27 is his, val or phe; aa 28 is pro, tyr or thr; and aa 29 is leu, arg or phe.
Claim 10
Dependent Claim
11 words
A cationic oligopeptide according to claim 7 of the formula: ##STR14##
Claim 11
Dependent Claim
11 words
A cationic oligopetide according to claim 7 of the formula: ##STR15##
Claim 12
Dependent Claim
7 words
A cationic oligopeptide of the formula; ##STR16##
Claim 13
Dependent Claim
7 words
A cationic oligopeptide of the formula; ##STR16##
Claim 14
Dependent Claim
11 words
A cationic oligopeptide according to claim 7 of the formula: ##STR17##
Claim 15
Dependent Claim
32 words
In a formulation capable of supporting undesired microbial growth, the improvement which comprises including in said formulation in an amount sufficient to inhibit microbial growth, a cationic oligopeptide according to claim 7.
Claim 16
Dependent Claim
10 words
A formulation according to claim 12, having a liquid carrier.
Claim 17
Dependent Claim
10 words
A formulation according to claim 12, having a solid carrier.
References Cited (Backward Citations)
US4543252A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-20 | 1990-10-20 | 1991-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-20 | 1994-10-20 | 1995-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-20 | 1998-10-20 | 1999-04-21 | $7700.00 | Window Closed / Lapsed |