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US4656269A
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Histidine derivatives
Assignee: Kissei Pharmaceutical Co Ltd
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Filing: 1986-04-15
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Granted: 1987-04-07
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Expires: 2006-04-15
Abstract
Abstract Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.
Inventors
- 👤 Kinji Iizuka
- 👤 Tetsuhide Kamijo
- 👤 Tetsuhiro Kubota
- 👤 Kenji Akahane
- 👤 Hideaki Umeyama
- 👤 Yoshiaki Kiso
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:57
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; Y; Y10; Y10S; Y10S530/00; Y10S530/86
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
85 words
An amino acid derivative represented by formula (I) ##STR17## wherein R 1 represents a monoalkylamino group having 1 to 3 carbon atoms, a dialkylamino group having 2 to 6 carbon atoms, or ##STR18## in which Y represents a chemical bond, an oxygen atom or a methylene group, His represents an L-histidyl group, n represents 0 or 1, X represents an oxygen atom or --NH--, R 2 represents a straight or branched-chain alkyl group having 1 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
85 words
An amino acid derivative represented by formula (I) ##STR17## wherein R 1 represents a monoalkylamino group having 1 to 3 carbon atoms, a dialkylamino group having 2 to 6 carbon atoms, or ##STR18## in which Y represents a chemical bond, an oxygen atom or a methylene group, His represents an L-histidyl group, n represents 0 or 1, X represents an oxygen atom or --NH--, R 2 represents a straight or branched-chain alkyl group having 1 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
46 words
An amino acid derivative as claimed in claim 1 represented by formula: ##STR19## wherein C* represents a carbon atom in the L-configuration, R 1 , His, n, X and R 2 have the same meanings as defined in claim 1, or a pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
39 words
An amino acid derivative as claimed in claim 2 represented by the formula: ##STR20## wherein R 1 , His, C*, X and R 2 have the same meanings as defined in claim 2, or a pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
38 words
An amino acid derivative as claimed in claim 2 represented by formula: ##STR21## wherein R 1 , His, C*, X and R 2 have the same meanings as defined in claim 2, or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR22## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR23## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR24## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR25## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR26## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR27## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR28## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR29## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR30## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
32 words
The amino acid derivative as claimed in claim 3 represented by formula: ##STR31## wherein His and C* have the same meanings as defined in claim 3, or a pharmaceutically acceptable salt thereof.
Claim 16
Dependent Claim
32 words
The amino acid derivative as claimed in claim 4 represented by formula: ##STR32## wherein His and C* have the same meanings as defined in claim 4, or a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim
32 words
The amino acid derivative as claimed in claim 4 represented by formula: ##STR33## wherein His and C* have the same meanings as defined in claim 4, or a pharmaceutically acceptable salt thereof.
Claim 18
Dependent Claim
32 words
The amino acid derivative as claimed in claim 4 represented by formula: ##STR34## wherein His and C* have the same meanings as claimed in claim 4, or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
JPS58188862A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-06 | 1990-10-06 | 1991-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-06 | 1994-10-06 | 1995-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-06 | 1998-10-06 | 1999-04-07 | $7700.00 | Window Closed / Lapsed |