US4656187A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of mammary cancer
Assignee: Eli Lilly and Co
•
Filing: 1983-12-01
•
Granted: 1987-04-07
•
Expires: 2003-12-01
Abstract
Abstract Mammary cancers are inhibited by administration of a combination of two drugs. The first compound is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, and the second compound is tamoxifen.
Inventors
- 👤 Larry J. Black
- 👤 James A. Clemens
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 00:14
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
41 words
A method of inhibiting the growth of estrogen-dependent mammary cancers comprising administering to a patient in need of such treatment about 20 mg./kg./day of a first compound which is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, and about 5 mg./kg./day of a second compound which is tamoxifen.
Claim 2
Independent Claim
41 words
A method of inhibiting the growth of estrogen-dependent mammary cancers comprising administering to a patient in need of such treatment about 20 mg./kg./day of a first compound which is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, and about 5 mg./kg./day of a second compound which is tamoxifen.
Claim 3
Dependent Claim
29 words
A pharmaceutical combination comprising about four parts by weight of a first compound which is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, and about one part by weight of a second compound which is tamoxifen.
Claim 4
Dependent Claim
29 words
A pharmaceutical combination comprising about four parts by weight of a first compound which is 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, and about one part by weight of a second compound which is tamoxifen.
References Cited (Backward Citations)
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Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-06 | 1990-10-06 | 1991-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-06 | 1994-10-06 | 1995-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-06 | 1998-10-06 | 1999-04-07 | $7700.00 | Window Closed / Lapsed |