US4650675A
Expired / Lapsed
US
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Oligonucleotide conjugates
Assignee: Boston Children's Hospital
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Filing: 1983-08-18
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Granted: 1987-03-17
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Expires: 2003-08-18
Abstract
Abstract Conjugate composed of an oligonucleotide covalently bonded to a carrier.
Inventors
- 👤 Yves Borel
- 👤 B. David Stollar
- 👤 Helina Borel
- 👤 Paul M. Gallop
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6807; Y; Y10; Y10S; Y10S530/00; Y10S530/868
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
82 words
A conjugate comprising an oligonucleotide covalently bonded to a carrier wherein said conjugate is a tolerogenic conjugate capable of inducing tolerance in a human patient suffering from SLE, comprising a heterogeneous DNA oligonucleotide at least 8 and not more than 500 base pairs in length covalently bonded to a non-antigenic, soluble isologous IgG immunoglobulin molecule, said covalent bonding being such that the conformation of said IgG immunoglobulin is similar enough to its natural conformation to render said conjugate tolerogenic rather than antigenic.
Claim 2
Dependent Claim
82 words
A conjugate comprising an oligonucleotide covalently bonded to a carrier wherein said conjugate is a tolerogenic conjugate capable of inducing tolerance in a human patient suffering from SLE, comprising a heterogeneous DNA oligonucleotide at least 8 and not more than 500 base pairs in length covalently bonded to a non-antigenic, soluble isologous IgG immunoglobulin molecule, said covalent bonding being such that the conformation of said IgG immunoglobulin is similar enough to its natural conformation to render said conjugate tolerogenic rather than antigenic.
Claim 3
Dependent Claim
13 words
The conjugate of claim 1 wherein said IgG immunoglobulin in IgG 1 .
Claim 4
Dependent Claim
14 words
The conjugate of claim 1 wherein said covalent bonding is via an aldehydic linkage.
Claim 5
Dependent Claim
22 words
The conjugate of claim 1 wherein each said soluble isologous IgG immunoglobulin molecule has bonded to it between 0.7 and 1.2 oligonucleotides.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |