US3725545A
Expired / Lapsed
US
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Enhancement of antibody production by nucleic acid-polycation complexes
Assignee: Individual
•
Filing: 1971-02-03
•
Granted: 1973-04-03
•
Expires: 1991-02-03
Abstract
Abstract Complex substances capable of enhancing the production of antibodies when introduced in conjunction with an antigen into an animal host are produced by reacting single-stranded or multistranded nucleic acid polymers with cationically charged polymers having a molecular weight between about 103 and 108 in specified proportions, e.g., 50 parts of nucleic acid polymer to 1 part to 500 parts cationic polymer by weight.
Inventors
- 👤 R Maes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:32
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/39; A61K2039/555; A61K2039/55511
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
21 words
The process of claim 1 in which the molecular weight of said cationically charged polymer is between about 103 and 106.
Claim 2
Dependent Claim
26 words
The process of claim 1 wherein said nucleic acid polymer is selected from the group consisting of polyinosinic acid, polycytidylic acid, polyuridylic acid and polyadenylic acid.
Claim 3
Dependent Claim
101 words
In a process for potentiating the antibody producing ability of nucleic acid containing preparations the improvement comprising the incorporation therein of the product formed by reacting about 50 parts of a single-stranded or multi-stranded nucleic acid polymer with from 1 part to 500 parts of a cationically charged polymer having a molecular weight between about 103 and 107 and being selected from the group consisting of ornithine, lysine, citrulline, arginine, histidine and tryptophane, said parts being parts by weight, for inoculation into living animal hosts at doses ranging from about 1 to 5,000 micrograms of nucleic acid per kilo animal weight.
Claim 4
Dependent Claim
20 words
The process of claim 4 in which the molecular weight of said cationically charged polymer is between 104 and 106.
Claim 5
Dependent Claim
26 words
The process of claim 4 wherein said nucleic acid polymer is selected from the group consisting of polyinosinic acid, polycytidylic acid, polyuridylic acid and polyadenylic acid.
Claim 6
Dependent Claim
51 words
In a process for potentiating the antibody producing ability of nucleic acid containing preparations the improvement comprising the incorporation therein of the product formed by reacting about 50 parts of a single-stranded or multi-stranded nucleic acid polymer with from 1 to 500 parts of a cationically charged polymer of hexadimethrine bromide.
Claim 7
Dependent Claim
26 words
The process of claim 7 wherein said nucleic acid polymer is selected from the group consisting of polyinosinic acid, polycytidylic acid, polyuridylic acid and polyadenylic acid.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-04-02 | 1976-10-02 | 1977-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-04-02 | 1980-10-02 | 1981-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-04-02 | 1984-10-02 | 1985-04-03 | $7700.00 | Window Closed / Lapsed |