US4650674A
Expired / Lapsed
US
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Synergistic cytotoxic composition
Assignee: Genentech Inc
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Filing: 1984-12-03
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Granted: 1987-03-17
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Expires: 2004-12-03
Abstract
Abstract Compositions comprising an interferon and a cytotoxic protein designated tumor necrosis factor exhibit a synergistic cytotoxic effect on tumor cells.
Inventors
- 👤 Bharat B. Aggarwal
- 👤 Sang He Lee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:44
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/52; C07K14/525; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/68; G01N33/6863; A; A61; A61K; A61K38/00; C07K2319/00; C07K2319/01; C07K2319/02; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/143; Y10S930/144
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
39 words
A cell free composition suitable for the treatment of tumors comprising (a) a human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE and (b) a human interferon, which composition is free of lymphotoxin.
Claim 2
Dependent Claim
39 words
A cell free composition suitable for the treatment of tumors comprising (a) a human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE and (b) a human interferon, which composition is free of lymphotoxin.
Claim 3
Dependent Claim
18 words
The composition of claim 1 which is free of other polypeptides which are cytotoxic for murine L-929 cells.
Claim 4
Dependent Claim
8 words
The composition of claim 1 which is lyophilized.
Claim 5
Dependent Claim
11 words
The composition of claim 1 wherein the interferon is gamma interferon.
Claim 6
Dependent Claim
28 words
A method for the treatment of tumors comprising administering the composition of claim 1 to a tumor-bearing animal in an amount which is effective in treating the tumor.
Claim 7
Dependent Claim
14 words
The method of claim 5 wherein the amount is sufficient to cause tumor necrosis.
Claim 8
Dependent Claim
30 words
A composition suitable for the treatment of tumors consisting essentially of human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE and a human interferon.
Claim 9
Dependent Claim
30 words
A composition suitable for the treatment of tumors consisting essentially of human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE and a human interferon.
Claim 10
Independent Claim
51 words
A method suitable for the treatment of tumors comprising administering a human interferon to a tumor cell within an animal, followed by administering to the cell human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE, in amounts effective to cause cytolysis of said tumor cell.
Claim 11
Independent Claim
51 words
A method suitable for the treatment of tumors comprising administering a human interferon to a tumor cell within an animal, followed by administering to the cell human unglycosylated tumor necrosis factor having a molecular weight of about 17,000 daltons on SDS-PAGE, in amounts effective to cause cytolysis of said tumor cell.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |