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US4649047A
Expired / Lapsed
US
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Ophthalmic treatment by topical administration of cyclosporin
Assignee: University of Georgia Research Foundation Inc
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Filing: 1985-03-19
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Granted: 1987-03-10
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Expires: 2005-03-19
Abstract
Abstract The present invention relates to a method for the treatment of either phacoanaphylactic endophthalmitis or uveitis by administering at least one cyclosporin topically to the eyes. Topical application of cyclosporin provides cyclosporin to the anterior chamber, the posterior chamber and the vitreous body of the eye.
Inventors
- 👤 Renee Kaswan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:56
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K38/12; A61K38/13; A61K9/00; A61K9/0012; A61K9/0048; A61K9/10; A61K9/127
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
31 words
A method for the treatment of phacoanaphylactic endophthalmitis in the anterior or posterior segment of an eye which comprises administering a therapeutically effective amount of a cyclosporin topically to said eye.
Claim 2
Independent Claim
31 words
A method for the treatment of phacoanaphylactic endophthalmitis in the anterior or posterior segment of an eye which comprises administering a therapeutically effective amount of a cyclosporin topically to said eye.
Claim 3
Independent Claim
30 words
A method for the treatment of uveitis in the anterior or posterior segment of an eye which comprises administering a therapeutically effective amount of a cyclosporin topically to said eye.
Claim 4
Independent Claim
30 words
A method for the treatment of uveitis in the anterior or posterior segment of an eye which comprises administering a therapeutically effective amount of a cyclosporin topically to said eye.
Claim 5
Dependent Claim
21 words
The method of claim 1 wherein from 0.1 to 50 wt % of cyclosporin in a medically suitable excipient is used.
Claim 6
Dependent Claim
21 words
The method of claim 2 wherein from 0.1 to 50 wt. % of cyclosporin in a medically acceptable excipient is used.
Claim 7
Dependent Claim
15 words
The method of claim 3 wherein the medically suitable excipient comprises animal or vegetable oil.
Claim 8
Dependent Claim
15 words
The method of claim 4 wherein the medically suitable excipient comprises animal or vegetable oil.
Claim 9
Dependent Claim
31 words
The method of claim 3 wherein the medically suitable excipient comprises olive oil, arachis oil, castor oil, mineral oil, petroleum jelly, dimethyl sulphoxide, an alcohol, silicone fluid or a mixture thereof.
Claim 10
Dependent Claim
32 words
The method of claim 4 wherein the medically suitable excipient comprises olive oil, arachis oil, liposome, castor oil, mineral oil, petroleum jelly, dimethyl sulphoxide, an alcohol, silicone fluid or a mixture thereof.
Claim 11
Dependent Claim
16 words
The method of claim 1 wherein the cyclosporin is a natural cyclosporin or a synthetic cyclosporin.
Claim 12
Dependent Claim
16 words
The method of claim 2 wherein the cyclosporin is a natural cyclosporin or a synthetic cyclosporin.
Claim 13
Dependent Claim
23 words
The method of claim 3 wherein the medically suitable excipient comprises polyvinyl alcohol, polyoxethylated castor oil or methyl cellulose or a mixture thereof.
Claim 14
Dependent Claim
22 words
The method of claim 4 wherein the medically suitable excipient comprises polyvinyl alcohol, polyoxethylated castor oil, methyl cellulose or a mixture thereof.
Claim 15
Dependent Claim
13 words
The method of claim 7 wherein the medically suitable excipient is dimethyl sulphoxide.
Claim 16
Dependent Claim
13 words
The method of claim 8 wherein the medically suitable excipient is dimethyl sulphoxide.
Claim 17
Dependent Claim
10 words
The method of claim 1, wherein Cyclosporin A is used.
Claim 18
Dependent Claim
11 words
The method of claim 2, wherein said cyclosporin is Cyclosporin A.
Claim 19
Dependent Claim
13 words
The method of claim 1, wherein said phacoanaphylactic endophthalmitis is traumatic phacoanapylactic endothalmitis.
Claim 20
Dependent Claim
11 words
The method of claim 2, wherein said uveitis is iatrogenic-lens-induced uveitis.
Claim 21
Independent Claim
40 words
A method for the treatment of a disorder caused by excessive immune activity in the anterior or posterior segment of an eye, which comprises topically administering to said eye an amount of a cyclosporin sufficient to reduce said immune activity.
Claim 22
Independent Claim
40 words
A method for the treatment of a disorder caused by excessive immune activity in the anterior or posterior segment of an eye, which comprises topically administering to said eye an amount of a cyclosporin sufficient to reduce said immune activity.
Claim 23
Independent Claim
38 words
A method for the treatment of a disorder caused by excessive immune activity in the vitrous body of an eye, which comprises topically administering to said eye an amount of a cyclosporin sufficient to reduce said immune activity.
Claim 24
Independent Claim
38 words
A method for the treatment of a disorder caused by excessive immune activity in the vitrous body of an eye, which comprises topically administering to said eye an amount of a cyclosporin sufficient to reduce said immune activity.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-09 | 1990-09-08 | 1991-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-09 | 1994-09-08 | 1995-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-09 | 1998-09-08 | 1999-03-10 | $7700.00 | Window Closed / Lapsed |