Treatment for tissue degenerative inflammatory disease

Claim 1

A method for treatment of destructive connective tissue inflammatory disease selected from the group consisting of (1) periodontal disease characterized by a chronic inflammation of gingival tissue leading to destruction of connective tissues surrounding the teeth (2) osteoarthritis characterized by chronic inflammation of the connective tissue surrounding skeletal joints in an animal or human afflicted with such disease, which method comprises oral administration of the following substances in the relative weight proportions indicated: ascorbic acid, 1 to 5 parts; biologically available calcium, 2 to 10 parts, provided by a calcium source selected from the group consisting of bone meal, biologically compatible calcium salts and calcium-containing foods; a precursor or stimulant of epinephrine or nor-epinephrine selected from tyrosine and phenylalanine, 0.5 to 2.5 parts; and an anti-inflammatory substance, 1 to 5 parts, said anti-inflammatory substance being selected from the group consisting of amino sugars glucosamine, D-mannosamine, D-galactosamine, their biocompatible acid addition salts, glucosamine-6-phosphate, N-acetyl-D-glucosamine, the sugars 2-deoxy-D-glucose, 2-deoxy-D-galactose and mannose, and the amino acids cysteine, creatine, creatinine, L-tryptophan, valine, alanine, glycine, glutamine, aspartic acid, and S-methylcysteine; in which method said substances are administered in amounts effective to reduce or prevent tissue degenerative effects of the inflammatory disease and to promote connective tissue regrowth.

Claim 2

A method for treatment of destructive connective tissue inflammatory disease selected from the group consisting of (1) periodontal disease characterized by a chronic inflammation of gingival tissue leading to destruction of connective tissues surrounding the teeth (2) osteoarthritis characterized by chronic inflammation of the connective tissue surrounding skeletal joints in an animal or human afflicted with such disease, which method comprises oral administration of the following substances in the relative weight proportions indicated: ascorbic acid, 1 to 5 parts; biologically available calcium, 2 to 10 parts, provided by a calcium source selected from the group consisting of bone meal, biologically compatible calcium salts and calcium-containing foods; a precursor or stimulant of epinephrine or nor-epinephrine selected from tyrosine and phenylalanine, 0.5 to 2.5 parts; and an anti-inflammatory substance, 1 to 5 parts, said anti-inflammatory substance being selected from the group consisting of amino sugars glucosamine, D-mannosamine, D-galactosamine, their biocompatible acid addition salts, glucosamine-6-phosphate, N-acetyl-D-glucosamine, the sugars 2-deoxy-D-glucose, 2-deoxy-D-galactose and mannose, and the amino acids cysteine, creatine, creatinine, L-tryptophan, valine, alanine, glycine, glutamine, aspartic acid, and S-methylcysteine; in which method said substances are administered in amounts effective to reduce or prevent tissue degenerative effects of the inflammatory disease and to promote connective tissue regrowth.

Claim 23

A method for treatment and prevention of periodontitis, a disease characterized by a chronic inflammation of gingival tissue leading to destruction of connective tissues surrounding the teeth, in a human whose daily dietary intake of calcium-containing foods is sufficient to provide an average of at least 10 milligrams of biologically available calcium for every kilogram of body weight, said method comprising applying to the gingival-tooth junction in an amount effective to reduce or prevent tissue destructive effects of the disease and to promote tissue regrowth, a composition comprising the following ingredients, expressed in parts by weight: absorbic acid, 1 to 5 parts; a precursor or stimulant or epinephrine or nor-epinephrine production selected from tyrosine or phenylalanine, 0.5 to 2.5 parts; and an anti-inflammatory substance, 1 to 5 parts, said anti-inflammatory substance being selected from the amino sugars glucosamine, D-mannosamine, D-galactosamine; their biocompatible acid addition salts; glucosamine-6-phosphate, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, UDP-N-acetylglucosamine; the sugars 2-deoxy-D-glucose, 2-deoxy-D-galactose and mannose; and the amino acids cysteine, creatine, creatinine, L-tryptophan, valine, alanine, glycine, glutamine, aspartic acid, and S-methylcysteine.

Claim 24

A method for treatment and prevention of periodontitis, a disease characterized by a chronic inflammation of gingival tissue leading to destruction of connective tissues surrounding the teeth, in a human whose daily dietary intake of calcium-containing foods is sufficient to provide an average of at least 10 milligrams of biologically available calcium for every kilogram of body weight, said method comprising applying to the gingival-tooth junction in an amount effective to reduce or prevent tissue destructive effects of the disease and to promote tissue regrowth, a composition comprising the following ingredients, expressed in parts by weight: absorbic acid, 1 to 5 parts; a precursor or stimulant or epinephrine or nor-epinephrine production selected from tyrosine or phenylalanine, 0.5 to 2.5 parts; and an anti-inflammatory substance, 1 to 5 parts, said anti-inflammatory substance being selected from the amino sugars glucosamine, D-mannosamine, D-galactosamine; their biocompatible acid addition salts; glucosamine-6-phosphate, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, UDP-N-acetylglucosamine; the sugars 2-deoxy-D-glucose, 2-deoxy-D-galactose and mannose; and the amino acids cysteine, creatine, creatinine, L-tryptophan, valine, alanine, glycine, glutamine, aspartic acid, and S-methylcysteine.