US4477428A
Expired / Lapsed
US
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Oral compositions comprising N.sup.α,NG -diacyl derivatives of arginine
Assignee: Johnson and Johnson Hospital Services Inc
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Filing: 1982-08-26
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Granted: 1984-10-16
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Expires: 2002-08-26
Abstract
Abstract Oral hygiene formulations incorporating N alpha ,NG-diacyl derivatives of arginine, or the pharmaceutically acceptable salts thereof, optionally in combination with fluoride compounds, are effective in combatting microorganisms, inhibiting acid production and reducing dental caries.
Inventors
- 👤 Steven B. Silbering
- 👤 Tibor Sipos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:14
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61Q; A61Q11/00
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
26 words
N.sup.α,N G -diacyl derivatives of arginine having the formula: ##STR5## where y is an integer of from 0 to 28, and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
26 words
N.sup.α,N G -diacyl derivatives of arginine having the formula: ##STR5## where y is an integer of from 0 to 28, and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
39 words
A compound of claim 1 wherein said pharmaceutically acceptable salts are selected from the group consisting of alkali metal salts, alkaline earth metal salts, amphoteric metal salts, heavy metal salts, organic base salts, and organic and inorganic acid salts.
Claim 4
Dependent Claim
14 words
The compound of claim 1 wherein said derivative of arginine is N.sup.α,N G -dioctanoylarginine.
Claim 5
Dependent Claim
14 words
The compound of claim 1 wherein said derivative of arginine is N.sup.α,N G -didecanoylarginine.
Claim 6
Dependent Claim
14 words
The compound of claim 1 wherein said derivative of arginine is N.sup.α,N G -dilauroylarginine.
Claim 7
Dependent Claim
14 words
The compound of claim 1 wherein said derivative of arginine is N.sup.α,N G -dimyristoylarginine.
Claim 8
Dependent Claim
14 words
The compound of claim 1 wherein said derivative of arginine is N.sup.α,N G -dipalmitoylarginine.
Claim 9
Dependent Claim
54 words
A composition of matter for oral hygiene to inhibit acid production by microorganisms in the oral cavity comprising an effective amount, in a pharmaceutically acceptable carrier, of an N.sup.α,N G -diacyl derivative of arginine having the formula; ##STR6## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
54 words
A composition of matter for oral hygiene to inhibit acid production by microorganisms in the oral cavity comprising an effective amount, in a pharmaceutically acceptable carrier, of an N.sup.α,N G -diacyl derivative of arginine having the formula; ##STR6## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
16 words
The composition of matter of claim 8 wherein said derivative of arginine is N.sup.α,N G -dioctanoylarginine.
Claim 12
Dependent Claim
16 words
The composition of matter of claim 8 wherein said derivative of arginine is N.sup.α,N G -didecanoylarginine.
Claim 13
Dependent Claim
16 words
The composition of matter of claim 8 wherein said derivative of arginine is N.sup.α,N G -dilauroylarginine.
Claim 14
Dependent Claim
16 words
The composition of matter of claim 8 wherein said derivative of arginine is N.sup.α,N G -dimyristoylarginine.
Claim 15
Dependent Claim
16 words
The composition of matter of claim 8 wherein said derivative of arginine is N.sup.α,N G -dipalmitoylarginine.
Claim 16
Dependent Claim
15 words
The composition of matter of claim 8 wherein said pharmaceutically acceptable carrier is a dentifrice.
Claim 17
Dependent Claim
15 words
The composition of matter of claim 8 wherein said pharmaceutically acceptable carrier is a lozenge.
Claim 18
Dependent Claim
61 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR7## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 19
Dependent Claim
61 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR7## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 20
Dependent Claim
15 words
The composition of matter of claim 16 wherein said pharmaceutically acceptable carrier is a mouthrinse.
Claim 21
Dependent Claim
15 words
The composition of matter of claim 16 wherein said pharmaceutically acceptable carrier is a dentifrice.
Claim 22
Dependent Claim
66 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising from about 0.05 to about 10% of N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR8## whereby y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 23
Dependent Claim
66 words
A composition of matter for oral hygiene to inhibit the formation of caries comprising from about 0.05 to about 10% of N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR8## whereby y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 24
Dependent Claim
16 words
The composition of matter of claim 19 wherein said derivative of arginine is N.sup.α,N G -didecanoylarginine.
Claim 25
Independent Claim
55 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity in a pharmaceutically acceptable carrier, an effective amount of an N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR9## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 26
Independent Claim
55 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity in a pharmaceutically acceptable carrier, an effective amount of an N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR9## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 27
Independent Claim
69 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR10## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 28
Independent Claim
69 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising, in a pharmaceutically acceptable carrier, from about 0.0001% to about 10% of a fluoride salt and an effective amount of an N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR10## wherein y is an integer of from 0 to 28, or a pharmaceutically acceptable salt thereof.
Claim 29
Independent Claim
74 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising from about 0.05 to about 10% of N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR11## wherein y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
Claim 30
Independent Claim
74 words
A method for inhibiting acid production by microorganisms in the oral cavity which comprises introducing into the oral cavity a composition comprising from about 0.05 to about 10% of N.sup.α,N G -diacyl derivative of arginine having the formula: ##STR11## wherein y is an integer of from 4 to 18, or a pharmaceutically acceptable salt thereof, in combination with from about 0.001 to about 1.0% of a fluoride salt in a pharmaceutically acceptable polyol-containing vehicle.
References Cited (Backward Citations)
US2772203A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-16 | 1988-04-16 | 1988-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-16 | 1992-04-16 | 1992-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-16 | 1996-04-16 | 1996-10-16 | $7700.00 | Window Closed / Lapsed |