US4647446A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rapid brain scanning radiopharmaceutical
Assignee: University of California Berkeley
•
Filing: 1985-05-09
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Granted: 1987-03-03
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Expires: 2005-05-09
Abstract
Abstract A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula I is administered to one animal: ##STR1## wherein R 1 and R 2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R 3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R 4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R 4 is not isopropyl and when R 4 is methyl, R 3 is not benzyl; and X is a radioactive halogen.
Inventors
- 👤 Thornton W. Sargent, III
- 👤 Alexander T. Shulgin
- 👤 Chester A. Mathis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:12
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0404; A61K51/0406; A61K2123/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
90 words
A radioactively labelled compound of the formula I: ##STR7## wherein R 1 and R 2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R 3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R 4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos R 4 is not isopropyl and when R 4 is methyl, R 3 is not benzyl; and X is a radioactive halogen.
Claim 2
Dependent Claim
90 words
A radioactively labelled compound of the formula I: ##STR7## wherein R 1 and R 2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R 3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R 4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos R 4 is not isopropyl and when R 4 is methyl, R 3 is not benzyl; and X is a radioactive halogen.
Claim 3
Dependent Claim
30 words
A compound according to claim 1 wherein X is 122 I, 123 I, 124 I, 125 I, 131 I, 74 Br, 75 Br, 76 Br, 34m Cl, or 18 F.
Claim 4
Dependent Claim
21 words
A compound according to claim 2 wherein R 3 and R 4 are independently alkyl of 1 to 6 carbon atoms.
Claim 5
Dependent Claim
20 words
A compound according to claim 3 wherein X is 122 I, 123 I, 124 I, 125 I or 131 I.
Claim 6
Dependent Claim
25 words
A compound according to claim 4 wherein R 1 , R 2 , R 3 and R 4 are methyl and X is 122 I.
Claim 7
Dependent Claim
5 words
2,4-Dimethoxy-5-iodo-N,N-dimethylamphetamine according to claim 5.
Claim 8
Dependent Claim
5 words
2,6-Dimethoxy-3-iodo-N,N-dimethylamphetamine according to claim 5.
Claim 9
Dependent Claim
5 words
3,5-Dimethoxy-4-iodo-N,N-dimethylamphetamine according to claim 5.
Claim 10
Dependent Claim
5 words
2,4-Dialkoxy-5-halo-N,N-dialkylamphetamine according to claim 1.
Claim 11
Dependent Claim
5 words
2,6-Dialkoxy-3-halo-N,N-dialkylamphetamine according to claim 1.
Claim 12
Dependent Claim
5 words
3,5-Dialkoxy-2-halo-N,N-dialkylamphetamine according to claim 1.
Claim 13
Dependent Claim
17 words
A compound according to claim 9, 10 or 11 wherein R 1 and R 2 are methyl.
Claim 14
Dependent Claim
14 words
The compound according to claim 12 wherein R 3 and R 4 are methyl.
Claim 15
Dependent Claim
20 words
A compound according to claim 13 wherein R 3 and R 4 are alkyl of 1 to 6 carbon atoms.
Claim 16
Independent Claim
112 words
A method of measuring cerebral blood flow in mammals comprising the step of administering to said animal a detectable amount of a radioactively labelled compound of the formula I: ##STR8## wherein R 1 and R 2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R 3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R 4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R 4 is not isopropyl and when R 4 is methyl, R 3 is not benzyl; and X is a radioactive halogen.
Claim 17
Independent Claim
112 words
A method of measuring cerebral blood flow in mammals comprising the step of administering to said animal a detectable amount of a radioactively labelled compound of the formula I: ##STR8## wherein R 1 and R 2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R 3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R 4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R 4 is not isopropyl and when R 4 is methyl, R 3 is not benzyl; and X is a radioactive halogen.
Claim 18
Dependent Claim
12 words
A method according to claim 15 wherein said compound is administered intravenously.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-02 | 1990-09-01 | 1991-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-02 | 1994-09-01 | 1995-03-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-02 | 1998-09-01 | 1999-03-03 | $7700.00 | Window Closed / Lapsed |