US4284619A
Expired / Lapsed
US
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Esters useful as brain imaging agents
Assignee: Medi Physics Inc
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Filing: 1978-11-29
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Granted: 1981-08-18
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Expires: 1998-11-29
Abstract
Abstract Certain radioiodine containing esters useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula ##STR1## wherein I is a radioisotope of iodine with iodine-123 being preferred and R is selected from the group consisting of alkyl, aryl, substituted aryl, aralkyl, a polyhydric alcohol radical and a 5- or 6-membered heterocyclic ring.
Inventors
- 👤 Tz-Hong Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:16
CPC Classifications
C; C07; C07C; C07C69/00; C07C69/76; C07C69/78
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
71 words
A method of imaging the brain comprising intravenously injecting into a patient an effective amount of a composition comprising a compound of the formula ##STR4## wherein I is a radioisotope of iodine, and R is selected from the group consisting of alkyl, aryl, substituted aryl, aralkyl, a polyhydric alcohol, and a 5- or 6-membered heterocyclic ring, in a carrier suitable for intravenous injection and scanning the brain with a scintiscanning means.
Claim 2
Independent Claim
71 words
A method of imaging the brain comprising intravenously injecting into a patient an effective amount of a composition comprising a compound of the formula ##STR4## wherein I is a radioisotope of iodine, and R is selected from the group consisting of alkyl, aryl, substituted aryl, aralkyl, a polyhydric alcohol, and a 5- or 6-membered heterocyclic ring, in a carrier suitable for intravenous injection and scanning the brain with a scintiscanning means.
Claim 3
Dependent Claim
11 words
A method in accordance with claim 1 wherein I is iodine-123.
Claim 4
Dependent Claim
15 words
A method in accordance with claim 1 wherein I is ortho to the ester group.
Claim 5
Dependent Claim
13 words
A method in accordance with claim 1 wherein said compound is I-123 ethyl-o-iodobenzoate.
Claim 6
Dependent Claim
13 words
A method in accordance with claim 1 wherein said compound is I-123 glyceryl-o-iodobenzoate.
Claim 7
Dependent Claim
13 words
A method in accordance with claim 1 wherein said compound is I-123 benzyl-o-iodobenzoate.
References Cited (Backward Citations)
US3144479A
Cited
US3317569A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-17 | 1985-02-16 | 1985-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-17 | 1989-02-16 | 1989-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-17 | 1993-02-16 | 1993-08-18 | $7700.00 | Window Closed / Lapsed |